scholarly journals Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication

2021 ◽  
Vol Volume 14 ◽  
pp. 3307-3322
Author(s):  
Gashaw Dessie ◽  
Birhanu Ayelign ◽  
Yonas Akalu ◽  
Tewodros Shibabaw ◽  
Meseret Derbew Molla
Keyword(s):  
Therapeutic Target ◽  
Cardiovascular Complication ◽  
Inflammatory Disorders

scholarly journals Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target?

2021 ◽  
pp. 188596
Author(s):  
Keerthi Kurma ◽  
Andrea Boizard-Moracchini ◽  
Gael Galli ◽  
Mickael Jean ◽  
Pierre Vacher ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Inflammatory Disorders

scholarly journals PKCζ as a promising therapeutic target for TNFα-induced inflammatory disorders in chronic cutaneous wounds

2017 ◽  
Vol 40 (5) ◽  
pp. 1335-1346 ◽  
Author(s):  
Jian Zhang ◽  
Xuekang Yang ◽  
Hongtao Wang ◽  
Bin Zhao ◽  
Xue Wu ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Inflammatory Disorders ◽  
Cutaneous Wounds ◽  
Promising Therapeutic Target

The Th17 Pathway as a Therapeutic Target in Rheumatoid Arthritis and Other Autoimmune and Inflammatory Disorders

BioDrugs ◽  
2013 ◽  
Vol 27 (5) ◽  
pp. 439-452 ◽  
Author(s):  
Debbie M. Roeleveld ◽  
Annemarie E. M. van Nieuwenhuijze ◽  
Wim B. van den Berg ◽  
Marije I. Koenders
Keyword(s):  
Rheumatoid Arthritis ◽  
Therapeutic Target ◽  
Inflammatory Disorders

The Role of Heat Shock Protein -90 (HSP-90) in Inflammatory Disorders

2020 ◽  
Vol 14 (1) ◽  
pp. 30-37
Author(s):  
Chiranjib Bhattacharjee ◽  
Lokesh Deb
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Autoimmune Diseases ◽  
Therapeutic Target ◽  
Histone Deacetylase Inhibitors ◽  
Inflammatory Diseases ◽  
Cell Cycle Control ◽  
Heat Shock Protein 90 ◽  
Inflammatory Disorders ◽  
Hsp 90

In human cells, Heat Shock Protein-90 (HSP-90) is present in the cytosol, nucleoplasm, endoplasmic reticulum, and mitochondria. The eukaryotic HSP-90 is multifunctionary and essential for cell viability, signal transduction, cell-cycle control as well as transcriptional regulation. The intracellular environment does not restrict HSP-90. It has a vital role in all types of inflammatory disorders, including cancer, autoimmune diseases, infectious inflammatory conditions. Hence, pharmacological inhibition of HSP-90 is currently a choice of therapeutic target for the treatment of autoimmune diseases, cancer, and infectious diseases. Based on the biology of HSP-90, several COOH-terminal ATPase sites of HSP-90, NH2-terminal ATPase sites of HSP-90, and Histone deacetylase inhibitors are evaluated and classified under various groups. For the treatment of different inflammatory disorders, HSP-90 identified as a promising therapeutic target. The present review may guide researchers for evaluating the HSP-90 targeted pathway as a useful therapeutic target for inflammatory diseases, including cancers.

HMGB-1 AS A THERAPEUTIC TARGET FOR INFECTIOUS AND INFLAMMATORY DISORDERS

Shock ◽  
2006 ◽  
Vol 25 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Lin L Mantell ◽  
William R Parrish ◽  
Luis Ulloa
Keyword(s):  
Therapeutic Target ◽  
Inflammatory Disorders

Myeloid differentiation 2 as a therapeutic target of inflammatory disorders

2012 ◽  
Vol 133 (3) ◽  
pp. 291-298 ◽  
Author(s):  
Sun Hong Park ◽  
Nam Doo Kim ◽  
Jae-Kyung Jung ◽  
Chong-Kil Lee ◽  
Sang-Bae Han ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Myeloid Differentiation ◽  
Inflammatory Disorders

IL-21 as a therapeutic target in inflammatory disorders

2014 ◽  
Vol 18 (11) ◽  
pp. 1329-1338 ◽  
Author(s):  
Davide Di Fusco ◽  
Roberta Izzo ◽  
Michele M Figliuzzi ◽  
Francesco Pallone ◽  
Giovanni Monteleone
Keyword(s):  
Therapeutic Target ◽  
Inflammatory Disorders
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