scholarly journals The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study

2021 ◽  
Vol Volume 14 ◽  
pp. 2673-2682
Author(s):  
Peng Yu ◽  
Li Huang ◽  
Zhihan Wang ◽  
Xiaoyu Meng ◽  
Xuefeng Yu
Keyword(s):  
Insulin Resistance ◽  
Uric Acid ◽  
Beta Cell ◽  
Serum Uric Acid ◽  
Beta Cell Function ◽  
Cell Function ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Analysis of the relationship between body mass index, insulin resistance, and beta-cell function: A cross-sectional study using the minimal model

Metabolism ◽  
2004 ◽  
Vol 53 (11) ◽  
pp. 1462-1466 ◽  
Author(s):  
Daniel A. Garcı́a-Estévez ◽  
David Araújo-Vilar ◽  
Ángeles Saavedra-González ◽  
Gloria Fiestras-Janeiro ◽  
José Cabezas-Cerrato
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Beta Cell ◽  
Minimal Model ◽  
Beta Cell Function ◽  
Cell Function ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

scholarly journals Caffeine and Caffeine Metabolites in Relation to Insulin Resistance and Beta Cell Function in U.S. Adults

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1783
Author(s):  
Sohyae Lee ◽  
Jin-young Min ◽  
Kyoung-bok Min
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
High Performance ◽  
Cell Function ◽  
Cross Sectional Study ◽  
Caffeine Intake ◽  
Model Assessment ◽  
Cross Sectional ◽  
Glucose Levels

The relationship between caffeine and insulin resistance (IR) has been assessed only in terms of caffeine intake, and the association between caffeine and beta cell function (BCF) remains unclear. This study examines the association between urinary caffeine and its metabolites, IR, and BCF in nondiabetic, noninstitutionalized US adults in order to account for the inter-individual differences in caffeine metabolism. Data on urinary caffeine and its metabolites, IR and BCF from adults aged 20 years and older who participated in the 2009–2010 and 2011–2012 National Health and Nutrition Examination Surveys were analyzed (n for caffeine = 994). IR and BCF were assessed using homeostatic model assessment (HOMA) and urinary caffeine and its metabolites were measured using high-performance liquid chromatography-electrospray ionization-tandem quadrupole mass spectrometry. After adjusting for all covariates, increases in urinary 1,3-DMU, 1,7-DMU, 1,3,7-TMU, theophylline, paraxanthine, caffeine, and AAMU were significantly associated with increased HOMA-IR and HOMA-β (HOMA of insulin resistance and beta cell function). Compared with individuals in the lowest quartile of urinary 1,3-DMU, 1,7-DMU, 1,3,7-TMU, theophylline, paraxanthine, caffeine, and AAMU, the regression coefficients for HOMA-IR and HOMA-β were significantly higher among those in the highest quartile. After stratification by prediabetes status, HOMA-IR and HOMA-β showed significant positive associations with urinary caffeine and its metabolites among subjects with normal fasting plasma glucose levels. Our cross-sectional study showed that caffeine and its metabolites were positively related to IR and BCF.

scholarly journals Changes Over Time in Uric Acid in Relation to Changes in Insulin Sensitivity, Beta-Cell Function, and Glycemia

2019 ◽  
Vol 105 (3) ◽  
pp. e651-e659
Author(s):  
Alessandro Volpe ◽  
Chang Ye ◽  
Anthony J Hanley ◽  
Philip W Connelly ◽  
Bernard Zinman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Uric Acid ◽  
Insulin Sensitivity ◽  
Beta Cell ◽  
Serum Uric Acid ◽  
Beta Cell Function ◽  
Cell Function ◽  
Matsuda Index ◽  
Changes Over Time ◽  
Over Time

Abstract Context Serum uric acid has been linked to risk of type 2 diabetes (T2DM), but debate persists as to whether it plays a causal role. Indeed, it is unclear if changes in uric acid relate to the pathophysiologic determinants of T2DM (insulin resistance, beta-cell dysfunction), as would be expected if causal. Objective To evaluate the impact of changes in uric acid over 2 years on changes in insulin sensitivity, beta-cell function, and glycemia in women with and without recent gestational diabetes (GDM), a model of the early natural history of T2DM. Design/Setting/Participants At both 1 and 3 years postpartum, 299 women (96 with recent GDM) underwent uric acid measurement and oral glucose tolerance tests that enabled assessment of insulin sensitivity/resistance (Matsuda index, homeostasis model assessment of insulin resistance [HOMA-IR]), beta-cell function (insulin secretion-sensitivity index-2 [ISSI-2], insulinogenic index/HOMA-IR [IGI/HOMA-IR]), and glucose tolerance. Results Women with recent GDM had higher serum uric acid than their peers at both 1 year (281 ± 69 vs 262 ± 58 µmol/L, P = 0.01) and 3 years postpartum (271 ± 59 vs 256 ± 55 µmol/L, P = 0.03), coupled with lower insulin sensitivity, poorer beta-cell function, and greater glycemia (all P < 0.05). However, on fully adjusted analyses, neither uric acid at 1 year nor its change from 1 to 3 years was independently associated with any of the following metabolic outcomes at 3 years postpartum: Matsuda index, HOMA-IR, ISSI-2, IGI/HOMA-IR, fasting glucose, 2-hour glucose, or glucose intolerance. Conclusion Serum uric acid does not track with changes over time in insulin sensitivity, beta-cell function, or glycemia in women with recent GDM, providing evidence against causality in its association with diabetes.

scholarly journals Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nurshad Ali ◽  
Shakil Mahmood ◽  
Farjana Islam ◽  
Shahnaz Rahman ◽  
Tangigul Haque ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional
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