scholarly journals Predictors of Poor Plasma Glucose Maintenance in Type II Diabetic People with Ophthalmic Complication: The Case of Dessie Hospitals in Ethiopia

2021 ◽  
Vol Volume 14 ◽  
pp. 2317-2324
Author(s):  
Mohammed Abdu Seid ◽  
Baye Dagnew
Keyword(s):  
Plasma Glucose ◽  
Type Ii ◽  
Ophthalmic Complication

scholarly journals Hypercortisolaemia and dyslipidaemia in a selected diabetic population

2018 ◽  
Vol 9 (4) ◽  
pp. 143
Author(s):  
Adediji Isaac Oluwole ◽  
Ayodele Ademola Adelakun ◽  
Afolabi Joy Oluwaseyifunmi ◽  
Akinleye Waheed A ◽  
Taiwo Timilehin Darasimi
Keyword(s):  
Total Cholesterol ◽  
Plasma Glucose ◽  
Type Ii Diabetes ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Serum Cortisol ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Obese Subjects

Background: Type II DM and obesity are metabolic disorders characterized by insulin resistance, dyslipidaemia, and metabolic stress. These features were assessed in patients using fasting plasma glucose, fasting lipid profile and serum cortisol as their markers.Materials and methods: Ninety participants were recruited and classified into 3 groups of thirty each – Obese with type II DM, Non-obese with type II DM, non-obese and non-diabetics who served as controls. Anthropometric measures of weight and height were taken using standard procedures and body mass index was calculated thereafter. Blood samples were collected after an overnight fast for the in vitro assay of serum cortisol, plasma glucose, triglycerides, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol using enzyme linked immunosorbent assay and colorimetry as appropriate. Data obtained were analyzed statistically using ANOVA and post hoc test for comparison of variables between groups. Pearson’s correlation was performed to assess the relationship between variables and p<0.05 was considered significant.Results: Serum cortisol, plasma glucose, total cholesterol, triglycerides and LDL-cholesterol were elevated while HDL-cholesterol was reduced in both obese and non-obese subjects with type II diabetes mellitus when compared with controls. Cortisol had a significant positive association with plasma glucose, total cholesterol, triglycerides and LDL-cholesterol in obese subjects with type II diabetes mellitus while cortisol had a significant inverse relationship with HDL-cholesterol in both obese and non-obese subjects with type II diabetes mellitus.Conclusion: From this study, we conclude that elevated serum cortisol, a consequence of type II DM, accompanies dyslipidaemia in both obese and non-obese type II DM patients. It could therefore be inferred that ‘diabetic stress’ is the underlying factor of elevated cortisol in this group.

scholarly journals The influence of plasma glucose upon pulsatile ocular blood flow in subjects with Type II diabetes mellitus

Diabetologia ◽  
2001 ◽  
Vol 44 (6) ◽  
pp. 700-705 ◽  
Author(s):  
R. L. Perrott ◽  
R. V. North ◽  
N. Drasdo ◽  
K. A. Ahmed ◽  
D. R. Owens
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Plasma Glucose ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Ocular Blood Flow ◽  
Type Ii ◽  
Pulsatile Ocular Blood Flow

scholarly journals Leptin and Its Relation to Obesity and Insulin in the SHR/N-corpulent Rat, A Model of Type II Diabetes Mellitus

2001 ◽  
Vol 2 (3) ◽  
pp. 217-223 ◽  
Author(s):  
Manuel T. Velasquez ◽  
Sam J. Bhathena ◽  
Carl T. Hansen
Keyword(s):  
Animal Model ◽  
Plasma Glucose ◽  
Type Ii Diabetes ◽  
Plasma Insulin ◽  
Entire Group ◽  
Type Ii ◽  
Fasting Plasma ◽  
Obesity And Diabetes ◽  
Obese Rats ◽  
Plasma Leptin

The spontaneously hypertensive/NIH-corpulent (SHR/N-cp) rat is a genetic animal model that exhibits obesity, metabolic features of hyperinsulinemia, hyperglycemia, and hyperlipidemia, which are characteristic of type II diabetes and mild hypertension. To determine the role of leptin, the protein product of theobgene, in the development of obesity and diabetes in this model, we measured steady-state circulating levels of leptin in obese and lean SHR/N-cp rats and examined the relation between plasma leptin levels and metabolic variables at the stage of established obesity in these animals. Mean fasting plasma leptin concentration was 8-fold higher in obese than in lean rats (p<0.01). This was associated with a 6-fold elevation in plasma insulin in the obese group. Fasting levels of plasma glucose, cholesterol, and triglyceride were all significantly higher in obese rats than in lean controls. Spearman correlation analysis showed a significant positive correlation between plasma leptin concentration and body weight among the animals (r=0.73, p<0.01). Similarly, plasma insulin concentration was significantly correlated with BW in all animals (r=0.54, p<0.05). There was also a significant positive.correlation between plasma leptin and plasma insulin in the entire group (r=0.70, p<0.01). However, this relationship was significant only for lean rats but not for obese rats (r=0.59, p<0.05 for lean rats, and r=0.23, p=NS, for obese rats). Plasma leptin also correlated positively with fasting plasma glucose (r=0.75, p<0.05), total cholesterol (r=0.63, p<0.05), and triglyceride (r=0.67, p <0.05). The marked elevation of plasma leptin in obese SHR/N-cp rats suggests that obesity in this animal model is related to up-regulation of the ob gene. Circulating leptin appears to be one of the best biological markers of obesity and that hyperleptinemia is closely associated with several metabolic risk factors related to insulin resistance in the diabesity syndrome.

Effect of short-term carvedilol therapy on salivary and plasma oxidative stress parameters and plasma glucose level in type II diabetes

Therapy ◽  
2006 ◽  
Vol 3 (1) ◽  
pp. 119-123 ◽  
Author(s):  
Bagher Larijani ◽  
Mojgan Afshari ◽  
Fatemeh Astanehi-Asghari ◽  
Alireza Mojtahedi ◽  
Ali Rezaie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glucose Level ◽  
Plasma Glucose ◽  
Type Ii Diabetes ◽  
Plasma Glucose Level ◽  
Type Ii ◽  
Short Term ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Effect of sulfonylurea therapy and plasma glucose levels on hemoglobin A1c in type II diabetes mellitus

1981 ◽  
Vol 70 (2) ◽  
pp. 373-378 ◽  
Author(s):  
T.A. Schultz ◽  
S.B. Lewis ◽  
J.L. Davis ◽  
C.R. Rost ◽  
M.M. Bliziotes
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Glucose ◽  
Type Ii Diabetes ◽  
Hemoglobin A1c ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Glucose Levels

scholarly journals Effect of Caffeine on Plasma Glucose and Insulin Response to Mixed Meal Tolerance Test in Type II Diabetes

2012 ◽  
Vol 22 (2) ◽  
pp. 73-74
Author(s):  
Abu Saleh Md. Moosa ◽  
Shahina Akther
Keyword(s):  
Plasma Glucose ◽  
Type Ii Diabetes ◽  
Insulin Response ◽  
Tolerance Test ◽  
Caffeine Intake ◽  
Diabetic Patients ◽  
Type Ii ◽  
Mixed Meal ◽  
Meal Tolerance Test ◽  
Mixed Meal Tolerance Test

Caffeine containing beverages is widely used and popular world-wide. Studies showed that caffeine acutely decreased insulin sensitivity in young, non-diabetic adults.3-5 This double-blind study was carried out with habitual coffee drinkers who had at least a 6-months history of type II diabetes. The effects of caffeine on fasting glucose & insulin levels and on glucose & insulin response to a mixed-meal tolerance test were studied. The total daily caffeine intake was 375 mg in a divided schedule. Overnight fast and caffeine abstinence baseline fasting blood samples were drawn then after administration of caffeine (250 mg/day) or placebo they consumed a commercial meal that contained 75 gram of carbohydrate for mixed-meal tolerance test. Comparisons of the AUC2h values demonstrated significant caffeine effects for both plasma glucose and plasma insulin (P < 0.05) responses to the mixed-meal tolerance test. Caffeine did not affect the fasting levels of plasma glucose or insulin when compared with placebo. It may be concluded that acute administration of caffeine plus carbohydrate impaired post-prandial glucose metabolism and insulin responses. Such effects could have implication for the management of type II diabetic patients. Medicine Today 2010 Volume 22 Number 02 Page 73-74 DOI: http://dx.doi.org/10.3329/medtoday.v22i2.12437

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