scholarly journals Red Blood Cell Parameters and Their Correlation with Renal Function Tests Among Diabetes Mellitus Patients: A Comparative Cross-Sectional Study

2020 ◽  
Vol Volume 13 ◽  
pp. 3937-3946
Author(s):  
Tiruneh Adane ◽  
Zegeye Getaneh ◽  
Fikir Asrie
2014 ◽  
Vol 31 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Esma Altunoğlu ◽  
Cüneyt Müderrisoğlu ◽  
Füsun Erdenen ◽  
Ender Ülgen ◽  
M. Cem Ar

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Baomin Wang ◽  
Yumei Yang ◽  
Haoyue Yuan ◽  
Xiaomu Li

Background. Glucose metabolism is frequently impaired in patients with Cushing’s syndrome (CS) due to chronic exposure to excess glucocorticoids. Inflammation plays an essential role in the pathophysiology of diabetes mellitus (DM). The present study aimed to investigate the potential associations of inflammatory blood cell parameters, including white blood cell (WBC) count, neutrophil count, neutrophilic granulocyte percentage (NEUT%), lymphocyte count (LYM), and lymphocyte proportion (LYM%), with diabetes mellitus in Cushing's syndrome patients. Materials and Methods. The cross-sectional study was conducted in Zhongshan Hospital of Fudan University, China. A total of 150 patients with Cushing’s syndrome were retrospectively screened from 2017 to 2019. The demographic data, clinical data, and blood samples (lipids, adrenal, glucose, and inflammatory blood cell parameters) were recorded. Statistical analyses were carried out by using the SPSS software package, version 13.0. Results. In this study, the prevalence of diabetes mellitus was 38.7% in patients with Cushing’s syndrome. Patients with DM had higher WBC, neutrophil, NEUT% levels than patients without DM ( p < 0.05 ). As the NEUT% increased, a stepwise increase in glucose and glycated hemoglobin (HbA1c) level was observed. In addition, in the multivariate logistic regression, NEUT% was a significant independent risk factor for DM, regardless of gender, age, body mass index (BMI), and triglyceride and 12 midnight cortisol (12 MN cortisol) level (OR = 2.542, 95% CI 1.337–4.835, p < 0.001 ). Conclusions. In conclusion, elevated NEUT% level was linked to diabetes in patients with Cushing’s syndrome. The neutrophilic granulocyte percentage may be referred to as a new predictor for diabetes in Cushing’s syndrome patients.


2021 ◽  
Vol 22 (12) ◽  
pp. 1060-1064
Author(s):  
Peiwen Zhang ◽  
Dandan Xu ◽  
Xinhan Zhang ◽  
Mengyin Wu ◽  
Xuecheng Yao ◽  
...  

2018 ◽  
Vol 35 (2) ◽  
pp. 304-312
Author(s):  
Shokoufeh Aalaei ◽  
Shahram Amini ◽  
Mohammad Reza Keramati ◽  
Hadi Shahraki ◽  
Saeid Eslami

2020 ◽  
Author(s):  
Koichiro Matsumura ◽  
Toshika Okumiya ◽  
Tetsuro Sugiura ◽  
Nobuyuki Takahashi ◽  
Yoshihiro Yamamoto ◽  
...  

Abstract Background: The causes of anaemia in patients with end-stage renal disease include a relative deficiency in erythropoietin production and complex clinical conditions. We aimed to investigate the underlying mechanisms of anaemia in patients with end-stage renal disease who were undergoing maintenance dialysis by measuring erythrocyte creatine levels.Methods: In a cross-sectional study, we evaluated 69 patients with end-stage renal disease who were receiving haemodialysis (n = 55) or peritoneal dialysis (n = 14). Erythrocyte creatine level, a quantitative marker of mean red blood cell (RBC) age, was measured.Results: The mean RBC age was significantly shorter in the haemodialysis group than in the peritoneal dialysis group (47.7 days vs. 59.8 days, p<0.0001), although the haemoglobin levels were comparable between the groups. A Spearman correlation coefficient analysis revealed that shortened RBC age positively correlated with transferrin saturation (r = 0.54), ferritin level (r= 0.47), and haptoglobin level (r = 0.39) but inversely related with reticulocyte (r = −0.36), weekly doses of erythropoiesis-stimulating agents (ESAs; r = −0.62), erythropoietin resistance index (r = −0.64), and intradialytic ultrafiltration rate (r = −0.32).Conclusions: Shortened RBC age was observed in patients who were receiving maintenance haemodialysis and was associated with iron deficiency, greater haptoglobin consumption, higher ESA requirements, and poor erythropoietin responsiveness, as well as with greater intradialytic fluid extraction.


2015 ◽  
Vol 240 (2) ◽  
pp. 431-436 ◽  
Author(s):  
João D. Fontes ◽  
Faisal Rahman ◽  
Sean Lacey ◽  
Martin G. Larson ◽  
Ramachandran S. Vasan ◽  
...  

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