scholarly journals Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences

2020 ◽  
Vol Volume 13 ◽  
pp. 3359-3369
Author(s):  
Ewa Kruszyńska ◽  
Maria Łoboz-Rudnicka ◽  
Carlo Palombo ◽  
Olga Vriz ◽  
Michaela Kozakova ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Sex Differences ◽  
Carotid Artery ◽  
Artery Stiffness

scholarly journals Mir-1, miR-122, miR-132, and miR-133 Are Related to Subclinical Aortic Atherosclerosis Associated with Metabolic Syndrome

2021 ◽  
Vol 18 (4) ◽  
pp. 1483
Author(s):  
Agnė Šatrauskienė ◽  
Rokas Navickas ◽  
Aleksandras Laucevičius ◽  
Tomas Krilavičius ◽  
Rūta Užupytė ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Linear Regression ◽  
Augmentation Index ◽  
Subclinical Atherosclerosis ◽  
Pearson Correlation ◽  
High Cardiovascular Risk ◽  
Negatively Associated ◽  
Artery Stiffness

Previously, miR-1, miR-122, miR-126, miR-132, miR-133, and miR-370 were found to be related to coronary artery disease (CAD) progression. However, their relationship with subclinical atherosclerosis, especially in subjects with metabolic syndrome, is unknown. Therefore, our aim was to determine their relationship with arterial markers of subclinical atherosclerosis. Metabolic syndrome subjects (n = 182) with high cardiovascular risk but without overt cardiovascular disease (CVD) were recruited from the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program. The ardio-ankle vascular index (CAVI), augmentation index normalized to a heart rate of 75 bpm (AIxHR75), aortic pulse wave velocity (AoPWV), and carotid artery stiffness were assessed. MicroRNAs (miRs) were analyzed in serum. Pearson correlation and a univariate linear regression t-test showed that miR-1, miR-133b, and miR-133a were negatively associated with CAVI mean, whereas miR-122 was positively associated. MiR-1, miR-133b and miR-133a, and miR-145 were negatively associated with AIxHR75. MiR-122 correlated negatively with AoPWV. In multivariate linear regression models, miR-133b and miR-122 predicted CAVImean, miR-133 predicted AIxHR75, and miR-122 predicted AoPWV. MiR-132 predicted right carotid artery stiffness, and miR-1 predicted left carotid artery stiffness. The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. Age and triglycerides enhanced the prediction of AoPWV by miR-122. A cluster of four miRs are related to subclinical atherosclerosis in subjects with metabolic syndrome. Combined, they may have a more substantial diagnostic or prognostic value than any single miR. Future follow-up studies are needed to establish their clinical relevance.

scholarly journals Metabolic Syndrome Increases Carotid Artery Stiffness: the Northern Manhattan Study

2010 ◽  
Vol 5 (3) ◽  
pp. 138-144 ◽  
Author(s):  
David Della-Morte ◽  
Hannah Gardener ◽  
Federica Denaro ◽  
Bernadette Boden-Albala ◽  
Mitchell S. V. Elkind ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Carotid Artery ◽  
Artery Stiffness

Abstract 040: Comparison of Effects of Reux en Y Gastric Bypass and Intra-abdominal Lipectomy on Cardiovascular Function in the Metabolic Syndrome

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Amanda Soler ◽  
Brenda Hutcheson ◽  
Jenny Yang ◽  
Chastity Bradford ◽  
Frank Zhang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Gastric Bypass ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Carotid Artery ◽  
Abdominal Adipose Tissue ◽  
The Metabolic Syndrome ◽  
Artery Stiffness ◽  
Abdominal Lipectomy

Central (visceral) obesity is a key feature of the metabolic syndrome and an independent predictor of cardiovascular disease. Reux en Y gastric bypass (RnY) has been shown to offer protection against cardiovascular disease, but residual risk remains. It is also unknown whether the cardiovascular benefit is a consequence of a decrease in visceral (intra-abdominal) adipose tissue or of other factors. In this study, we compared the effects of RnY vs. removal of 90% of visceral adipose tissue (=5% body weight) by intra-abdominal lipectomy on cardiac function (echocardiography), macrovascular function (carotid artery stiffness) and microvascular function (coronary artery endothelium-dependent vasorelaxation) in a metabolic syndrome rat model (JCR:LA-cp, JCR). Cardiac output (CO) and ejection fraction (EF) were significantly decreased in JCR vs. normal (Sprague-Dawley, SD) rats (CO=50±5%, EF=45±2% of normal), and were significantly improved by both RnY and intra-abdominal lipectomy (CO=75±6%, EF=82±2% and CO=80±3%, EF=90±2% of normal, respectively). Likewise, acetylcholine-dependent coronary artery vasorelaxation was impaired in JCR rats (50±1% of normal), and was significantly improved by both RnY and intra-abdominal lipectomy (98±2% and 98±3% of normal, respectively). Carotid artery stiffness was significantly increased in JCR rats (~2 fold vs. SD), and was normalized by intra-abdominal lipectomy (to equal SD), but not by RnY (~2 fold vs. SD). Intra-abdominal lipectomy but not RnY also decreased cardiac and vascular elastin degradation in JCR rats (Lipectomy: ~50% (heart), ~75% (carotid); RnY: ~15% (heart), ~5% (carotid) vs. untreated JCR, respectively), concomitant with a decrease in matrix metalloproteinase 12 (MMP12), a major elastase, activation (~50% (heart), ~75% (carotid), ~87% (visceral fat), ~75% (circulating) vs. untreated JCR) and in 20-hydroxyeicosatetraeonic acid (20-HETE) levels (~4 (heart), ~7 (carotid), ~4 (visceral fat), ~4 (circulating) fold vs. untreated JCR). Thus, our data indicate that intra-abdominal adipose tissue itself is a source of factors that may be important negative regulators of micro- and macrovascular and cardiac function, but are not eliminated by RnY.

Carotid Artery Stiffness in Obese Children With the Metabolic Syndrome

2006 ◽  
Vol 97 (4) ◽  
pp. 528-531 ◽  
Author(s):  
Arcangelo Iannuzzi ◽  
Maria Rosaria Licenziati ◽  
Ciro Acampora ◽  
Maurizio Renis ◽  
Mariano Agrusta ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Carotid Artery ◽  
Obese Children ◽  
The Metabolic Syndrome ◽  
Artery Stiffness

No Sex Differences in Carotid Artery Stiffness and Blood Flow Pulsatility Following High Intensity Exercise

2014 ◽  
Vol 46 ◽  
pp. 331-332
Author(s):  
Matthew C. Babcock ◽  
Briana K. Leyer ◽  
Kimberly L. Fitzgerald ◽  
Wesley K. Lefferts ◽  
William E. Hughes ◽  
...  
Keyword(s):  
Blood Flow ◽  
Sex Differences ◽  
Carotid Artery ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Flow Pulsatility ◽  
Artery Stiffness

scholarly journals Sex Differences in Predictors of Longitudinal Changes in Carotid Artery Stiffness

2015 ◽  
Vol 35 (2) ◽  
pp. 478-484 ◽  
Author(s):  
Rebecca Stern ◽  
Matthew C. Tattersall ◽  
Adam D. Gepner ◽  
Claudia E. Korcarz ◽  
Joel Kaufman ◽  
...  
Keyword(s):  
Sex Differences ◽  
Carotid Artery ◽  
Longitudinal Changes ◽  
Artery Stiffness

Common Carotid Artery Stiffness and Patterns of Left Ventricular Hypertrophy in Hypertensive Patients

Hypertension ◽  
1995 ◽  
Vol 25 (4) ◽  
pp. 651-659 ◽  
Author(s):  
Pierre Boutouyrie ◽  
Stéphane Laurent ◽  
Xavier Girerd ◽  
Athanase Benetos ◽  
Patrick Lacolley ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Left Ventricular Hypertrophy ◽  
Common Carotid Artery ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Artery Stiffness
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