scholarly journals Examination of the Relationship Between Metabolic Syndrome and Obstructive Sleep Apnea in Iranian Patients with Type 2 Diabetes: A Case–Control Study

2020 ◽  
Vol Volume 13 ◽  
pp. 2251-2257
Author(s):  
Pershang Sharifpour ◽  
Fazel Dehvan ◽  
Sahar Dalvand ◽  
Reza Ghanei Gheshlagh
Thrita ◽  
2016 ◽  
Vol 5 (4) ◽  
Author(s):  
Saeed Nouri ◽  
Raika Jamali ◽  
Kurosh Gharagozli ◽  
Mohammad Reza Sharif ◽  
Bardia Jamali

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Jian Zhu ◽  
Lu Yuan ◽  
Wen-ji Ni ◽  
Yong Luo ◽  
Jian-hua Ma

Insulin antibody (IA) may potentially affect a patient’s glycemic control due to its variability in both binding and/or releasing insulin. However, the association between IA titer and daily glycemic variability (GV) is still unknown. We thus performed this cross-sectional, retrospective case-control study to assess the relationship between IA titer and mean amplitude glycemic excursion (MAGE) in type 2 diabetes mellitus (T2DM) patients using a continuous glucose monitoring (CGM) system. We recruited 100 eligible patients (IA>5%, IA positive) and divided them into two groups—a low (L) group and a high (H) group—based on their IA titer. The control (C) group consisted of 47 patients (IA≤5%, IA negative) matched for age, BMI, gender, and glycosylated hemoglobin A1c (HbA1c). The CGM determined the GV of enrolled patients. The primary outcome was the relationship between the IA titer and the MAGE, and the secondary outcome was the differences of GV among the three groups. We found that patients in the H group had higher levels of blood glucose fluctuation parameters than those in the L and C groups. The Ln(IA) was positively correlated with Ln(MAGE) even after adjusting for age, gender, BMI, HbA1c, and fasting and postprandial C-peptide(r=0.423, p<0.001). Multiple linear stepwise regression analysis revealed that Ln(IA) was an independent factor of Ln(MAGE) (beta=0.405, p<0.001). In conclusion, the higher circulating IA titer was associated with increased MAGE in T2DM patients, indicating that those patients with elevated IA titer should receive GV assessment and individualized treatment.


2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Dahai Yu ◽  
Zhanzheng Zhao ◽  
David Simmons

Objective. To explore the relationship between mean arterial pressure (MAP), HbA1c, and cardiovascular (CV) hospitalisation risk in type 2 diabetes.Design. Population-based case-control study.Settings. Primary and secondary care level in Cambridgeshire, United Kingdom.Participants. 588 patients with type 2 diabetes from 18 English general practices recording a CV hospitalisation in 2009–2011 were included. Risk-set sampling was used to select 2920 gender, age, and practice matched control type 2 diabetes patients.Main Outcome Measure. Conditional logistic regression was used to explore further dose-response relationships between MAP, HbA1c, and CV hospitalisation risk.Results. The relationship between MAP and CV hospitalisation was nonlinear (P<0.001for linearity test). The MAP associated with the lowest CV hospitalisation risk was 97 (95% CI: 93–101) mmHg. An interaction between MAP and HbA1c for increased risk of cardiovascular hospitalisation was observed among those with HbA1c < 7% (53 mmol/mol) and MAP < 97 mmHg.Conclusions. In type 2 diabetes, MAP is a good predictor of CV hospitalisation risk. CV hospitalisation is lowest with a MAP between 93 and 101 mmHg. CV hospitalisation was particularly high among those with both a low MAP and a lower HbA1c.


2015 ◽  
Vol 20 (2) ◽  
pp. 845-851 ◽  
Author(s):  
Shabnam Jalilolghadr ◽  
Zohreh Yazdi ◽  
Manoochehr Mahram ◽  
Farkhondeh Babaei ◽  
Neda Esmailzadehha ◽  
...  

2016 ◽  
Vol 22 ◽  
pp. 183
Author(s):  
Shahjada Selim ◽  
Shahjada Selim ◽  
Shahabul Chowdhury ◽  
Mohammad Saifuddin ◽  
Marufa Mustary ◽  
...  

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