scholarly journals The Effect of Chilgoza Pine Nut (Pinus gerardiana Wall.) on Blood Glucose and Oxidative Stress in Diabetic Rats

2020 ◽  
Vol Volume 13 ◽  
pp. 2399-2408
Author(s):  
Seyed Ahmad Hosseini ◽  
Maryam Vali ◽  
Mohammad Hossein Haghighi-Zade ◽  
Amir Siahpoosh ◽  
Reza Malihi
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Diabetic Rats ◽  
Pine Nut ◽  
And Oxidative Stress ◽  
Pinus Gerardiana

Extract of Moringa concanensis Nimmo leaves ameliorates hyperglycemia and oxidative stress, and improves β-cell function in Alloxan monohydrate induced diabetic rat

2021 ◽  
Vol 17 ◽  
Author(s):  
Amerendra Singh ◽  
Jai Narayan Mishra ◽  
Santosh Kumar Singh ◽  
Vishal Kumar Vishwakarma ◽  
Shravan Kumar Paswan
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Diabetes Management ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Histopathological Analysis ◽  
Β Cells ◽  
Standard Drug ◽  
Alloxan Monohydrate ◽  
And Oxidative Stress

Background: The ethanomedicinal importance of Moringa concanensis Nimmo plant is reflected in Ayurvedic and traditional system of medicine. It brings out its importance as diverse plant in Ayurvedic preparation and diabetes management. Aims of study: The research was centred to bring out the Hyperglycemiccapabilities of Moringa concanensis Nimmo leaves Ethanolic extract (PE) on Alloxan monohydrate (AXM) induceddiabetic rat model. Materials and Methods: Wistar rats were made diabetic by AXM and treated with PE (200 mg/kg body weight) and glibenclamide as a standard drug. All Essential parameters like Fasting blood glucose (FBS), Post prandial blood glucose (PPBS), AST, ALT, ALP, ACP, LDH and oxidative stress markers were measured. Also to see β-cells structures histology of pancreas was also done. Results: The non toxicity of PE dose was confirmed by acute toxicity study and also this study models helped to know about the anti-hyperglycemic effects of PE by decreasing FBS and PPBS levels in the diabetic rats. It also enhances oxidative stress by decreasing MDA levels and elevating the GSH and SOD. The histopathological analysis helped us to know about structure decay of β-cells of pancreas tissue of diabetic rats. PEpotential was confirmed by serum enzymes AST, ALT, ALP, ACP and LDH as it showed significant decrease in diabetic rats. Conclusion: It was confirmed from the data that PE is efficient in governance of diabetes and its control, so there is a need to work at molecular level to bring out all its potential for the benefit of the society.

scholarly journals ANTIHYPERGLYCEMIC AND ANTIOXIDATIVE EFFECTS OF LYGODIUM MICROPHYLLUM IN ALLOXAN INDUCED DIABETIC RATS

2018 ◽  
Vol 10 (12) ◽  
pp. 75
Author(s):  
D. G. Syahidah Nadiah Binti Abdull Majid ◽  
Mohammad Iqbal
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Control Group ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Antioxidative Effects ◽  
And Oxidative Stress

Objective: The antihyperglycemic and antioxidative effects of L. microphyllum were evaluated by using in vivo methods in normal and alloxan induced diabetic rats.Methods: Diabetes was induced in Sprague Dawley rats by injecting alloxan through intravenous (i. v) at a dose of 100 mg/kg of body weight. Aqueous extract of L. microphyllum at different doses (400, 200 and 100 mg/kg of body weight) was administered orally (orogastric intubation) for 14 d. Blood glucose and oxidative stress markers were measured. Hematoxylin and eosin staining method were used to examine the pancreatic tissues.Results: At the 14 d interval, fasting blood glucose showed a reduction in serum glucose levels in animals pretreated with L. microphyllum compared with alloxan alone treated group. Oxidative stress was noticed in rat’s pancreatic tissue as evidenced by a significant decrease in glutathione level, glutathione reductase, glutathione-S-transferase, and catalase activities. Malondialdehyde showed a significant increase compared to the normal saline-treated control group. Serum biochemistry and oxidative stress markers were consistent with the pancreatic histopathological studies. Treatment of diabetic rats with L. microphyllum at a dose level of 100, 200 and 400 mg/kg body weight leaves extract for 14 d significantly prevented these alterations and attenuated alloxan-induced oxidative stress (P<0.05).Conclusion: The results of the present study indicated that the antihyperglycemic potential of L. microphyllum might be ascribable to its antioxidant and free radical scavenging properties. Thus, it is concluded that L. microphyllum may be helpful in the prevention of diabetic complications associated with oxidative stress.

Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats

2019 ◽  
Vol 30 (4) ◽  
Author(s):  
Praveen K. Kodumuri ◽  
Christofer Thomas ◽  
Raghu Jetti ◽  
Anil Kumar Pandey
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Cognitive Dysfunction ◽  
Memory Impairment ◽  
Neuronal Loss ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
And Oxidative Stress

Abstract Background Natural medicinal plants have been the focus of current research for developing neuroprotective agents to be used in the diabetes-linked cognitive dysfunction. Trigonella foenum-graecum seeds (known as fenugreek, methi in Hindi), is a well-known traditional medicinal herb and possesses anti-diabetic, anti-oxidant, and anti-inflammatory properties. Purpose This study was undertaken to explore the ameliorative effects of T. foenum-graecum seed extract on diabetes-induced cognitive dysfunction. Methods Experimental diabetes was induced by administering a single dose of streptozotocin (60 mg/kg) through intraperitoneal dose. Cognitive function was assessed using a T-maze and the Morris water maze. Lipid peroxidation levels and oxidative stress in the hippocampus was measured. Quantification of hippocampal CA1 and CA3 regions was done using cresyl violet stain. Results Diabetic rats demonstrated learning and memory impairment, which was evident from poor performance in behavioral tasks, i.e. T-maze and Morris water maze tasks. Learning and memory impairment in diabetic animals is associated with increased blood glucose levels, increased oxidative stress in the hippocampus and decreased number of neurons in the CA1 and CA3 regions of the hippocampus. The diabetic rats administered with T. foenum-graecum showed improved performance in behavioral tasks, and these changes were associated with decreased blood glucose levels, decreased oxidative stress in the hippocampus, and decreased neuronal loss from the CA1 and CA3 regions of the hippocampus. Conclusion In conclusion, administration of T. foenum-graecum seed extract ameliorates diabetes-linked cognitive dysfunction in rats by decreasing blood glucose levels, reducing lipid peroxidation and oxidative stress in the hippocampus, and preventing neuronal loss from the hippocampus.

Evaluation of 4-methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid against hyperglycemia, insulin sensitivity, and oxidative stress-induced inflammatory responses and β-cell damage in the pancreas of streptozotocin-induced diabetic rats

2017 ◽  
Vol 37 (2) ◽  
pp. 163-174 ◽  
Author(s):  
YN Paudel ◽  
MR Ali ◽  
S Bawa ◽  
S Shah ◽  
M Adil ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Insulin Sensitivity ◽  
Carboxylic Acid ◽  
Inflammatory Mediators ◽  
Antioxidant Status ◽  
Insulin Level ◽  
Pancreatic Tissue ◽  
Diabetic Rats ◽  
And Oxidative Stress

4-Methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid (bioactive compound (BAC)), a novel thiazole derivative, is a xanthine oxidase inhibitor and free radical scavenging agent. Effects of BAC on hyperglycemia, insulin sensitivity, oxidative stress, and inflammatory mediators were evaluated in streptozotocin (STZ)-induced neonatal models of non-insulin-dependent diabetes mellitus (NIDDM) rats where NIDDM was induced in neonatal pups with single intraperitoneal injection of STZ (100 mg/kg). The effect of BAC (10 and 20 mg/kg, p.o.) for 3 weeks was evaluated by the determination of blood glucose, oral glucose tolerance test (OGTT), HbA1c level, insulin level, insulin sensitivity, and insulin resistance (IR). Furthermore, inflammatory mediators (tumor necrosis factor-alpha and interleukin-6) and oxidative stress were estimated in serum and pancreatic tissue, respectively. Significant alteration in the level of blood glucose, OGTT, HbA1c, insulin level, insulin sensitivity, in addition variation in the antioxidant status and inflammatory mediators, and alteration in histoarchitecture of pancreatic tissue confirmed the potential of BAC in STZ-induced neonatal models of NIDDM rats. Pretreatment with BAC restored the level of glucose by decreasing the IR and increasing the insulin sensitivity. Furthermore, BAC balanced the antioxidant status and preserved the inflammatory mediators. Histological studies of pancreatic tissues showed normal architecture after BAC administration to diabetic rats. Altogether, our results suggest that BAC successfully reduces the blood glucose level and possesses antioxidant as well as anti-inflammatory activities. This leads to decreased histological damage in diabetic pancreatic tissues, suggesting the possibility of future diabetes treatments.

scholarly journals Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats

2020 ◽  
Vol 17 (6) ◽  
pp. 147916412096699
Author(s):  
Wenru Li ◽  
Chaonan Zhu ◽  
Tianheng Liu ◽  
Weifang Zhang ◽  
Xu Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Blood Glucose ◽  
Glycemic Control ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Control Group ◽  
And Oxidative Stress

Aims: The objective of this study was to explore the effects of epigallocatechin-3-gallate (EGCG) on type 2 diabetes mellitus (T2DM). Main methods: Male Sprague–Dawley rats were allocated into six groups. The control group received a conventional diet. The diabetic group received a high-sucrose high-fat (HSHF) diet for 4 weeks and then was fasted and injected with streptozotocin (STZ); subsequently, the rats received a HSHF diet for another 4 weeks to develop diabetes. The four treatment groups were diabetic rats that received intragastric metformin (500 mg/kg/day) or EGCG (25, 50, and 100 mg/kg/day) for 10 weeks. All groups except the control group received a HSHF diet throughout the experiment. Several biochemical parameters such as fasting blood glucose (FBG), postprandial blood glucose (PBG), liver glycogen, muscle glycogen, fasting serum insulin (FSI), homeostasis model of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), free fatty acids (FFA), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured to assess the effects of EGCG on glycemic control, insulin resistance, lipid profile, and oxidative stress. Furthermore, oxidative stress in pancreatic islet β cells was detected by dihydroethidium staining. Key findings: A HSHF diet and STZ injection induced T2DM, as indicated by changed blood glucose and body weight, which was accompanied by insulin resistance, an altered lipid profile, and oxidative stress. Interestingly, EGCG treatment dose-dependently recovered these indexes. Significance: EGCG successfully ameliorated glycemic control and insulin sensitivity while reducing the lipid profile and oxidative stress in a T2DM rat model.

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