scholarly journals Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats

2020 ◽  
Vol Volume 13 ◽  
pp. 2169-2177 ◽  
Author(s):  
Xiaobo Zhang ◽  
Ying Zhu ◽  
Ying Zhou ◽  
Bingru Fei
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Diabetic Rats ◽  
Renal Ischemia ◽  
Renal Ischemia Reperfusion Injury

scholarly journals Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats

Nefrología ◽  
2019 ◽  
Vol 39 (4) ◽  
pp. 411-423 ◽  
Author(s):  
Meltem Kumaş ◽  
Mukaddes Eşrefoğlu ◽  
Ersin Karataş ◽  
Nurcihan Duymaç ◽  
Songül Kanbay ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Diabetic Rats ◽  
Renal Ischemia ◽  
Renal Ischemia Reperfusion Injury ◽  
Dose Dependent

scholarly journals Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats

2019 ◽  
Vol 39 (4) ◽  
pp. 411-423
Author(s):  
Meltem Kumaş ◽  
Mukaddes Eşrefoğlu ◽  
Ersin Karataş ◽  
Nurcihan Duymaç ◽  
Songül Kanbay ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Diabetic Rats ◽  
Renal Ischemia ◽  
Renal Ischemia Reperfusion Injury ◽  
Dose Dependent

scholarly journals Renoprotective effects Of Dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats

2018 ◽  
Author(s):  
Seung Hyun Kim ◽  
Ji Hae Jun ◽  
Ju Eun Oh ◽  
Eun-Jung Shin ◽  
Young Jun Oh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Diabetic Rats ◽  
Post Treatment ◽  
Renal Ischemia ◽  
Erk Signaling ◽  
Renal Ischemia Reperfusion Injury ◽  
Pre Treatment

AbstractBackgroundDiabetic patients are susceptible to renal ischemia-reperfusion injury, which leads to perioperative complications. Nucleotide binding and oligomerization domain (NOD)-like receptor 3 inflammasome participates in the development of diabetes, and contributes to renal ischemia-reperfusion injury. Dexmedetomidine, a highly selective α2-adrenoreceptor agonist, shows renoprotective effects against ischemia-reperfusion injury. We aimed to elucidate the effects, underlying mechanisms, and optimal timing of dexmedetomidine treatment in diabetic rats.MethodsMale Sprague-Dawley rats (60 animals, weighing 250-300 g) were randomly divided into normal-sham, diabetes-sham, diabetes-ischemia-reperfusion-control, diabetes-ischemia-reperfusion-dexmedetomidine-pre-treatment, and diabetes-ischemia-reperfusion-dexmedetomidine-post-treatment groups. Renal ischemia-reperfusion injury was induced in diabetic rats by occlusion of both renal arteries for 45 minutes followed by reperfusion for 24 hours. Dexmedetomidine (10 μg/kg) was administered intraperitoneally 1 hour before ischemia (pre-treatment) or upon reperfusion (post-treatment). After reperfusion, renal tissue was biochemically and histopathologically evaluated.ResultsDexmedetomidine treatment attenuated IR-induced increase in NLRP3, caspase-1, IL-1β, phospho-AKT, and phospho-ERK signaling. Moreover, oxidative stress injury, inflammatory reactions, apoptosis, and renal tubular damage were favorably modulated by dexmedetomidine treatment. Furthermore, post-reperfusion treatment with dexmedetomidine was significantly more effective than pre-treatment in modulating inflammasome, AKT and ERK signaling, and oxidative stress.ConclusionsThis study shows that protective effects of dexmedetomidine in renal ischemia-reperfusion injury are preserved in diabetic conditions and may potentially provide a basis for the use of dexmedetomidine in clinical treatment of renal ischemia-reperfusion injury.

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