scholarly journals High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population

2020 ◽  
Vol Volume 13 ◽  
pp. 581-590 ◽  
Author(s):  
Guo-bao Hong ◽  
Pei-chun Gao ◽  
Yun-ying Chen ◽  
Yue Xia ◽  
Xiao-su Ke ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chinese Population ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Follow Up Study

scholarly journals Higher Levels of High-Sensitivity C-Reactive Protein Is Positively Associated with the Incidence of Hyperuricemia in Chinese Population: A Report from the China Health and Retirement Longitudinal Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Hui-Xu Dai ◽  
Zhi-Ying Zhao ◽  
Yang Xia ◽  
Qi-Jun Wu ◽  
Yu-Hong Zhao
Keyword(s):  
Cohort Study ◽  
Chinese Population ◽  
Cohort Analysis ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Subgroup Analyses ◽  
Longitudinal Association ◽  
Final Cohort

Purpose. The aim of the present cohort study was to explore the longitudinal association between high-sensitivity C-reactive protein (CRP) and hyperuricemia in Chinese population. Furthermore, we conducted subgroup analyses to explore this association according to age, sex, and body mass index. Methods. A total of 5,419 healthy participants were enrolled in the final cohort analysis. The high-sensitivity CRP level was measured by immunoturbidimetric assay. Hyperuricemia was defined as serum uric acid ≥7.0 mg/dL (416 μmol/L) in men and ≥6.0 mg/dL (357 μmol/L) in women. Multivariate logistic regression was used to analyze the association. Results. During the 4 years follow-up, 474 participants developed hyperuricemia. Compared with participants in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted odds ratio (OR) (95% confidence interval [CI]) for incident hyperuricemia in the highest tertile was 1.36 (1.02, 1.82). In the subgroup analyses, high-sensitivity CRP was positively associated with the incidence of hyperuricemia after multivariate adjustments (P for trend=0.04) in women. Compared with the women in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted OR (95% CI) in the highest tertile was 1.69 (1.10, 2.66). No statistically significant association was found in other subgroups. Conclusions. The findings of this prospective cohort study suggest that higher level of high-sensitivity CRP is an independent risk factor for hyperuricemia in Chinese, especially in women.

scholarly journals C-Reactive Protein and Metabolic Syndrome in Elderly Women: A 12-year follow-up study

Diabetes Care ◽  
2006 ◽  
Vol 29 (4) ◽  
pp. 931-932 ◽  
Author(s):  
M. Hassinen ◽  
T. A. Lakka ◽  
P. Komulainen ◽  
H. Gylling ◽  
A. Nissinen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Elderly Women ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Follow Up Study

High-sensitivity C reactive protein and risk of cardiovascular disease in China-CVD study

2018 ◽  
Vol 73 (2) ◽  
pp. 188-192 ◽  
Author(s):  
Ying Dong ◽  
Xin Wang ◽  
Linfeng Zhang ◽  
Zuo Chen ◽  
Congyi Zheng ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chinese Population ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
Net Reclassification Improvement ◽  
Increased Risk ◽  
Hs Crp

BackgroundThis study aimed to assess the association of high sensitivity C-reactive protein (hs-CRP) with cardiovascular disease (CVD) in middle-aged Chinese population.MethodsThe baseline was collected 2009–2010, and follow-up was conducted in 2016–2017. Data of hs-CRP were from baseline examination and re-examination in 2016–2017 using transmission turbidimetry with a measurement range of 0–42 000. The primary outcome was CVD including coronary heart disease events and stroke events.ResultsAmong 8688 participants free from CVD (at baseline, mean age, 50.1 years, 3897 were males), there were 189 CVD events, occurred during a median follow-up of 6.34 years (54 685 person-years at risk). From the Kaplan-Meier curve, we found that there was a progressive increase in CVD event rates by hs-CRP tertiles (log-rank test, p<0.001). Baseline hs-CRP was linearly associated with CVD (p for trend=0.015) even after adjusting for known CVD risk factors. Furthermore, the net reclassification improvement when hs-CRP was added to a model based on traditional factors was 7.85% for CVD (p=0.003). In addition, the correlation between change of hs-CRP and CVD was conducted in a subgroup (n=4778). However, we did not find the correlation between hs-CRP change and CVD (correlation coefficient: −0.003, p=0.846).ConclusionsIn the middle-aged Chinese population, hs-CRP was associated with increased risk of developing CVD. Although there was no correlation between hs-CRP change and CVD, the level of hs-CRP was higher at follow-up than baseline even among those with CVD. More attention should be given to those with higher level of hs-CRP for CVD prevention.

ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study

2017 ◽  
Vol 52 (7) ◽  
pp. 680-689
Author(s):  
Sheng-Yu Lee ◽  
Tzu-Yun Wang ◽  
Shiou-Lan Chen ◽  
Yun-Hsuan Chang ◽  
Po-See Chen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Function ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Follow Up Study ◽  
Cytokine Levels

Objectives: We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder. Methods: Patients with a first diagnosis of bipolar disorder were recruited. Symptom severity and levels of plasma cytokines (tumor necrosis factor α, C-reactive protein, interleukin 6 and transforming growth factor β1) were examined during weeks 0, 1, 2, 4, 8 and 12. Neurocognitive function was evaluated at baseline and endpoint. The ALDH2 polymorphism genotype was determined. Results: A total of 541 patients with bipolar disorder were recruited, and 355 (65.6%) completed the 12-week follow-up. A multiple linear regression analysis showed a significant ( p = 0.000226) association between the ALDH2 polymorphism and changes in C-reactive protein levels. Different aspects of cognitive function improved in patients with different ALDH2 genotypes. Only patients with the ALDH2*1*1 genotype showed significant correlations between improvement of cognitive function and increased transforming growth factor -β1. Conclusion: The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder. Additionally, changes in cytokine levels and cognitive function were correlated only in patients with specific ALDH2 genotypes.

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