scholarly journals ATP-Binding Cassette Transporter A1 (ABCA 1) Expression in Adipose Tissue and Its Modulation with Insulin Resistance in Obesity [Corrigendum]

2019 ◽  
Vol Volume 12 ◽  
pp. 2633-2634
Author(s):  
Vinnyfred Vincent ◽  
Himani Thakkar ◽  
Sandeep Aggarwal ◽  
Asit Mridha ◽  
Lakshmy Ramakrishnan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

scholarly journals ATP-binding cassette transporter A1 (ABCA1) expression in adipose tissue and its modulation with insulin resistance in obesity

2019 ◽  
Vol Volume 12 ◽  
pp. 275-284 ◽  
Author(s):  
Vinnyfred Vincent ◽  
Himani Thakkar ◽  
Sandeep Aggarwal ◽  
Asit Mridha ◽  
Lakshmy Ramakrishnan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Abca1 Expression ◽  
Atp Binding Cassette

scholarly journals Perivascular Adipose-Derived Exosomes Reduce Foam Cell Formation by Regulating Expression of Cholesterol Transporters

2021 ◽  
Vol 8 ◽  
Author(s):  
Yan Liu ◽  
Yan Sun ◽  
Xuze Lin ◽  
Dai Zhang ◽  
Chengping Hu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Accumulation ◽  
Foam Cell ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Foam Cell Formation ◽  
Atp Binding ◽  
Macrophage Foam Cell ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature of atherosclerosis. This study aimed to evaluate the effect of PVAT-derived exosomes (EXOs) on the lipid accumulation of macrophages and verify the anti-atherogenic characteristics of PVAT.Methods and Results: We extracted EXOs from the PVAT and subcutaneous adipose tissue (SCAT) of wild-type C57BL/6J mice. After coincubation, the EXOs were taken up by RAW264.7 cells. Oil Red O staining revealed that macrophage foam cell formation and intracellular lipid accumulation were ameliorated by PVAT-EXOs. Flow cytometry showed that PVAT-EXOs significantly reduced macrophage uptake of fluorescence-labelled oxidised low-density lipoprotein (ox-LDL). In addition, high-density lipoprotein-induced cholesterol efflux was promoted by PVAT-EXOs. Western blot analysis showed the downregulation of macrophage scavenger receptor A and the upregulation of ATP-binding cassette transporter A1 and ATP-binding cassette transporter G1, which could be mediated by the overexpression of peroxisome proliferator-activated receptor γ and was independent of liver X receptor α.Conclusion: Our findings suggest that PVAT-EXOs reduce macrophage foam cell formation by regulating the expression of cholesterol transport proteins, which provides a novel mechanism by which PVAT protects the vasculature from atherosclerosis.

scholarly journals Adipose Tissue ATP Binding Cassette Transporter A1 Contributes to High-Density Lipoprotein Biogenesis In Vivo

Circulation ◽  
2011 ◽  
Vol 124 (15) ◽  
pp. 1663-1672 ◽  
Author(s):  
Soonkyu Chung ◽  
Janet K. Sawyer ◽  
Abraham K. Gebre ◽  
Nobuyo Maeda ◽  
John S. Parks
Keyword(s):  
Adipose Tissue ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette
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