scholarly journals A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents

2020 ◽  
Vol Volume 13 ◽  
pp. 1653-1660
Author(s):  
Yongting Yuan ◽  
Hong Xie ◽  
Lili Sun ◽  
Bangxuan Wang ◽  
Li Zhang ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Impaired Fasting Glucose ◽  
Lipid Accumulation ◽  
Fasting Glucose ◽  
Chinese Children ◽  
Lipid Accumulation Product ◽  
Chinese Children And Adolescents

scholarly journals Prevalence and risk factors of impaired fasting glucose and diabetes among Chinese children and adolescents: a national observational study

2018 ◽  
Vol 120 (7) ◽  
pp. 813-819 ◽  
Author(s):  
Zhenghe Wang ◽  
Zhiyong Zou ◽  
Haijun Wang ◽  
Jin Jing ◽  
Jiayou Luo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Urban Children ◽  
Chinese Children ◽  
Rural Children ◽  
Obesity Prevalence ◽  
Fried Foods ◽  
Chinese Children And Adolescents

AbstractThe prevalence of impaired fasting glucose (IFG) and diabetes mellitus (DM) has reportedly increased significantly among Chinese children and adolescents. We aimed to examine the prevalence of IFG and DM, the disparities in sex and region and related risk factors among Chinese children and adolescents. A total of 16 434 Chinese children aged 6–17 years were selected from a national cross-sectional survey, and fasting glucose was measured for all participants. Overall, mean fasting plasma glucose (FPG) concentration was (4·64 (sd 0·51)) mmol/l, and the prevalence of DM and IFG was 0·10 and 1·89 %, respectively. Compared with girls, boys had higher FPG concentration (4·69 v. 4·58 mmol/l, r 0·107, P<0·001) and IFG prevalence (2·67 v. 1·07 %, rφ 0·059, P<0·001). Compared with rural children and adolescents, urban children and adolescent had higher FPG concentration (4·65 v. 4·62 mmol/l, r 0·029, P<0·001) and DM prevalence (0·15 v. 0·05 %, rφ 0·016, P<0·01). In addition, self-reported fried foods intake and overweight/obesity were positively associated with IFG, and the proportion of consuming fried foods more than or equal to once per week and overweight/obesity prevalence in boys and urban children and adolescents were significantly higher than girls and rural children and adolescents, respectively (P<0·05). Although the prevalence of IFG and DM was relatively low in Chinese children and adolescents, sex and region disparities were observed, which may be associated with differences in overweight/obesity prevalence and dietary factors.

A novel indicator, relative children’s lipid accumulation product (RCLAP) for metabolic syndrome

2020 ◽  
Author(s):  
Li Zhang ◽  
Zizhe Zhang ◽  
Bangxuan Wang ◽  
Yongting Yuan ◽  
Lili Sun ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Lipid Accumulation ◽  
Vigorous Physical Activity ◽  
Roc Curves ◽  
Chinese Children ◽  
Cluster Sampling ◽  
Activity Time ◽  
Lipid Accumulation Product ◽  
Increased Risk ◽  
Chinese Children And Adolescents

Abstract BackgroundThe children’s lipid accumulation product (CLAP) was associated with MS in Chinese children and adolescents. The study was to develop a more effective indicator, relative children’s lipid accumulation product （RCLAP）associated with MS reflect the density of lipid accumulation among Chinese children and adolescents. MethodsA stratified cluster sampling method was used to recruit 683 students aged 8-15 years in this study. The presence of MS was defined according to the NCEP-ATP III criteria. The t-test, chi-square test, logistic regression models were used to analyze the associations of SBMI, SWHtR, SlnCLAP, SRCLAP-H, SRCLAP-SH, RCLAP-W with MS. Receiver Operating Characteristic (ROC) curves was used to evaluate the predictive efficiency of above indexes for predicting MS. ResultsThe overall prevalence of MS was 4.8% (boys 6.6%, girls 2.8%). In girls, after adjusting for sedentary activity time, WHtR, BMI, CLAP, RCLAP-H, RCLAP-SH and RCLAP-W significantly increased risk of MS (OR(95%CI):15.79 (3.15-79.21), 3.73 (0.87-15.95), Null, 96.13 (11.11-831.97), 96.13 (11.11-831.97), 18.28 (4.24-78.87), respectively). In boys, after adjusting for ages and moderate-to-vigorous physical activity time, WHtR, BMI, CLAP, RCLAP-H, RCLAP-SH and SRCLAP-W significantly increased risk of MS (OR(95%CI): 37.43(11.67-120.10), 68.33(18.51-252.20), 105.86(21.99-509.68), 171.75(33.60-878.00), 133.18(27.65-641.39), 50.13(15.48-162.37, respectively). The AUCs of RCLAP-H and RCLAP-SH for predicting MS were 0.950, 0.948 in girls, and 0.952, 0.952 in boys, which were higher than these of BMI, WHtR, CLAP and RCLAP-W.ConclusionThe relative children，s lipid accumulation products（RCLAP-H and RCLAP-SH ) were more effective indicators for predicting MS than BMI, WHtR and CLAP in Chinese children and adolescents.

A novel indicator of children lipid accumulation product associated with dyslipidemia in Chinese children and adolescents

2020 ◽  
Author(s):  
Bangxuan Wang ◽  
Yongting Yuan ◽  
Jingyao Hu ◽  
Lili Sun ◽  
Rongying Yao ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Lipid Accumulation ◽  
Characteristic Curve ◽  
Body Height ◽  
Density Lipoprotein ◽  
Chinese Children ◽  
Lipoprotein Cholesterol ◽  
Lipid Accumulation Product ◽  
Optimal Value ◽  
Chinese Children And Adolescents

Abstract Background and aimsThe dyslipidemia contributed to more than half Cardiovascular disease (CVD) which ranked first in all causes of death in the world. Children’s lipid accumulation product (CLAP) is significantly related to cardiac metabolic risk factors in children and adolescents. The present study was to explore a novel indicator of children’s lipid accumulation product (CLAP) associated with dyslipidemia in Chinese children and adolescents.MethodsA total of 683 children and adolescents aged 8-15 years were recruited using the stratified cluster sampling method in this cross-sectional study, and were measured their body height, weight, waist circumference (WC), abdominal skinfold thickness (AST), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), dietary behaviors and physical activities. A logistic regression model and receiver operating characteristic curve (ROC curve) were used to compare the effects of CLAP for predicting dyslipidemia.ResultsThe prevalence of dyslipidemia was 13.6% (13.9% in boys and 13.2% in girls). The AUC (95%CI) of CLAP for predicting dyslipidemia was 0.76 (0.66-0.84) in girls, was 0.83 (0.76-0.89) in boys, and was higher than those of Sweight, SWC, SAST, SWHtR, and SBMI, respectively. The P85 of CLAP was the optimal value to predict dyslipidemia among girls (OR (95% CI): 10.54(5.09-21.82), AUC (95% CI): 0.72 (0.62-0.81). The P75 of CLAP was the optimal value to predict dyslipidemia among boys (OR (95% CI): 8.74(4.54-16.85), AUC (95% CI): 0.73 (95% CI 0.65-0.81).ConclusionsThe CLAP was a novel indicator associated with dyslipidemia in Chinese children and adolescents, and performed better than weight, WC, AST, WHtR, and BMI.

scholarly journals Interaction Analysis of Lipid Accumulation Product and Family History of Diabetes on Impaired Fasting Glucose and Diabetes Risk in Population with Normotension in Eastern China: A Community-based Cross-sectional Survey

2021 ◽  
Author(s):  
Li Shu ◽  
Yingying Zhao ◽  
Yanqi Shen ◽  
Xiaolu Li ◽  
Mengting Qiu ◽  
...  
Keyword(s):  
Family History ◽  
Impaired Fasting Glucose ◽  
Lipid Accumulation ◽  
Significant Interaction ◽  
Fasting Glucose ◽  
Diabetes Risk ◽  
Lipid Accumulation Product ◽  
Family History Of Diabetes ◽  
Significant Difference ◽  
History Of

Abstract Background: Lipid accumulation product (LAP) is considered to be a new convenient useful indicator to assess the visceral fat. However, the association between LAP and family history of diabetes remains an undetermined concept. Therefore, we aimed to evaluate the risk factors of impaired fasting glucose (IFG) and diabetes, and explore the possible interacting influences of LAP with other factors on the risk of IFG and diabetes among Chinese normotension adults.Methods: A multistage stratified cluster sampling method was conducted to select urban residents aged 45-86 years in Bengbu, China. For each eligible participant, data on questionnaire survey, anthropometric measurements and laboratory tests were obtained. LAP was calculated and divided into four categories according to quartile. The effects of body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR) and LAP for predicting IFG and diabetes were performed by multiple logistic regressions and receiver operating characteristic (ROC) analyses. The interaction effects were evaluated by relative excess risk of interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI). If the 95% CI of RERI and AP do not include 0, the 95% CI of SI do not include 1, the interactions are statistically significant. Results: 6467 normotension subjects (2695 men and 3772 women) were enrolled in our study, the prevalence of IFG and diabetes were 9.37% and 14.33%, respectively. It was revealed that the prevalence rates of IFG and diabetes were gradually increased according to increasing LAP quartiles (P for trend <0.001). When assessed using ROC curve analysis, LAP exhibited higher diagnostic accuracy for identifying IFG and diabetes than BMI, the area under the AUC curve was 0.650 (95% CI: 0.637 to 0.662). After adjustment for age, sex, educational level and other confounding factors, multivariate logistic regression analyses indicated that subjects with the fourth quartile of LAP were more likely to develop IFG (adjusted OR: 2.735, 95% CI: 1.794-4.170) and diabetes (adjusted OR: 1.815, 95% CI: 1.297-2.541) than those with the first quartile. A significant interaction between LAP and family history of diabetes was observed in participants (RERI=1.538, 95%CI: 0.167 to 3.612; AP=0.375, 95%CI: 0.118 to 0.631; SI=1.980, 95%CI: 1.206 to 3.251), but there is no statistically significant difference between LAP and general obesity. However, a significant interaction between LAP and abdominal obesity was indicated by the value of RERI (1.492, 95%CI: 0.087 to 3.723) and AP (0.413, 95%CI: 0.014 to 0.756), but not the value of SI (1.824, 95%CI: 0.873 to 3.526). Conclusion: LAP significantly associates with IFG and diabetes risk in the study population, it has better performance than BMI, WC and WHtR. Apart from that, our results also demonstrated that there might be synergistic effect between LAP and family history of diabetes on the risk of IFG and diabetes.

scholarly journals Association of the rs10830963 Polymorphism in MTNR1B with Fasting Glucose Levels in Chinese Children and Adolescents

Obesity Facts ◽  
2011 ◽  
Vol 4 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Jie-Yun Song ◽  
Hai-Jun Wang ◽  
Jun Ma ◽  
Zhi-Yuan Xu ◽  
Anke Hinney ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Fasting Glucose ◽  
Chinese Children ◽  
Glucose Levels ◽  
Chinese Children And Adolescents
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