scholarly journals Serum CTRP3 Levels In Obese Children: A Potential Protective Adipokine Of Obesity, Insulin Sensitivity And Pancreatic β Cell Function

2019 ◽  
Vol Volume 12 ◽  
pp. 1923-1930 ◽  
Author(s):  
Ting Chen ◽  
Fengyun Wang ◽  
Zhenyu Chu ◽  
Xiaoyan Shi ◽  
Ling Sun ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Cell Function ◽  
Pancreatic Β Cell ◽  
Obese Children ◽  
Β Cell ◽  
Β Cell Function

Circulating Spexin Decreased and Negatively Correlated with Systemic Insulin Sensitivity and Pancreatic β Cell Function in Obese Children

2019 ◽  
Vol 74 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Ting Chen ◽  
Fengyun Wang ◽  
Zhenyu Chu ◽  
Ling Sun ◽  
Haitao Lv ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Cell Function ◽  
Insulinogenic Index ◽  
Model Assessment ◽  
Pancreatic Β Cell ◽  
Obese Children ◽  
Β Cell ◽  
Β Cell Function ◽  
Obese Subjects

Objectives: Spexin (SPX) is a novel peptide that has recently emerged as an important regulatory adipokine of obesity and related metabolic disease. Little is known about its role in children. The aim of the current study was to determine the potential role of SPX in obese children and explore its relationships with obesity-related markers, insulin sensitivity and pancreatic β cell function. Method: We studied the levels of serum SPX in 40 obese and 32 normal weight pre-puberty children (mean age was 8.59 ± 1.82 and 8.15 ± 2.03 years in obesity and control groups respectively). We investigated the levels of body mass index, blood pressure, lipids, glucose, insulin, Homeostasis model assessment for insulin-resistant (HOMA-IR, HOMA for β-cell function [HOMA-β]), insulinogenic index and C-peptide index and analyzed their correlations with SPX levels. Results: SPX levels were significantly decreased in obese children compared to controls. Moreover, serum SPX levels were lower in IR obese subjects in contrast with the non-IR obese subjects. Serum SPX concentrations correlated negatively and significantly with triglycerides, systolic blood pressure, diastolic blood pressure, fasting insulin level, HOMA-IR, insulinogenic index, and HOMA-β levels in obese children. Conclusions: In summary, serum SPX levels significantly decreased in obese children and negatively correlated with insulin resistance and pancreatic β cell function indicators. Therefore, SPX may play a protective role in the process of glucose homeostasis and is closely related to β cell function in obese children.

scholarly journals Acute Effects of Blood Transfusion on Insulin Sensitivity and Pancreatic β-Cell Function in Children with β-Thalassemia/Hemoglobin E Disease

2018 ◽  
Vol 10 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Somboon Wankanit ◽  
Ampaiwan Chuansumrit ◽  
Preamrudee Poomthavorn ◽  
Patcharin Khlairit ◽  
Sarunyu Pongratanakul ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Blood Transfusion ◽  
Cell Function ◽  
Pancreatic Β Cell ◽  
Acute Effects ◽  
Β Cell ◽  
Hemoglobin E ◽  
Β Cell Function ◽  
Hemoglobin E Disease

Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism

Endocrine ◽  
2021 ◽  
Author(s):  
Shivraj Grewal ◽  
Andin Fosam ◽  
Liam Chalk ◽  
Arjun Deven ◽  
Mari Suzuki ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Primary Aldosteronism ◽  
Cell Function ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Β Cell Function

scholarly journals Insulin Sensitivity and Pancreatic β-Cell Function in Ecuadorian Women With Turner Syndrome

2020 ◽  
Vol 11 ◽  
Author(s):  
Francisco Álvarez-Nava ◽  
Daniela Bastidas ◽  
Marcia Racines-Orbe ◽  
Jéssica Guarderas
Keyword(s):  
Insulin Sensitivity ◽  
Turner Syndrome ◽  
Cell Function ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Β Cell Function

scholarly journals Plasma serpinB1 is related to insulin sensitivity but not pancreatic β -Cell function in non-diabetic adults

2017 ◽  
Vol 5 (5) ◽  
pp. e13193 ◽  
Author(s):  
Michael Glicksman ◽  
Asha Asthana ◽  
Brent S. Abel ◽  
Mary F. Walter ◽  
Monica C. Skarulis ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Cell Function ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Β Cell Function
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