scholarly journals Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study

2019 ◽  
Vol Volume 12 ◽  
pp. 1563-1569 ◽  
Author(s):  
Rui Ren ◽  
Yu Ma ◽  
Fang Deng ◽  
Tao Li ◽  
Hongyan Wang ◽  
...  
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
Serum Tsh ◽  
Tsh Levels

TSH LEVELS IN PRE- AND MENOPAUSE TRANSITION WOMEN: A POPULATION-BASED STUDY FROM SOUTH OF BRAZIL

Maturitas ◽  
2009 ◽  
Vol 63 ◽  
pp. S69
Author(s):  
K. Oppermann ◽  
S.C. Fuchs ◽  
H.R.K. Lisboa ◽  
P.M. Spritzer
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
Menopause Transition ◽  
South Of Brazil ◽  
Tsh Levels

scholarly journals Decreased serum TSH levels are not associated with mortality in the adult northeast German population

2010 ◽  
Vol 162 (3) ◽  
pp. 579-585 ◽  
Author(s):  
Till Ittermann ◽  
Robin Haring ◽  
Sybille Sauer ◽  
Henri Wallaschofski ◽  
Marcus Dörr ◽  
...  
Keyword(s):  
Cancer Mortality ◽  
Cox Regression ◽  
Large Population ◽  
Population Based ◽  
German Population ◽  
Free Triiodothyronine ◽  
Meta Analyses ◽  
Serum Tsh ◽  
Tsh Levels

ObjectiveResults of cohort studies on the association between decreased serum TSH levels and mortality are conflicting. Some studies demonstrated an increased mortality risk in subjects with decreased serum TSH levels, others did not. Even meta-analyses revealed contradictory results. We undertook the present study to investigate the association between decreased serum TSH levels and mortality in the large population-based Study of Health in Pomerania (SHIP).Design and methodsData from 3651 individuals from SHIP without known thyroid disorders or thyroid treatment were analyzed. Serum TSH, free triiodothyronine, and free thyroxine levels were determined by immunochemiluminescent procedures. Decreased TSH was defined as serum TSH levels below 0.25 mIU/l. Cox regression was used to associate decreased TSH levels with mortality.ResultsThe median duration of follow-up was 8.5 years (30 126 person years). During follow-up, 299 individuals (6.9%) died corresponding to a death rate of 9.92 deaths per 1000 person years. Survival time was shorter in subjects with decreased serum TSH levels compared to euthyroid individuals. After adjustment for age and sex, however, there was no association between decreased serum TSH levels and all-cause mortality (hazard ratio: 0.95; 95% confidence interval: 0.67; 1.36). Likewise, decreased serum TSH levels were neither associated with cardiovascular nor with cancer mortality.ConclusionsThere is no independent association of decreased serum TSH levels with all-cause, cardiovascular, and cancer mortality in the adult northeast German population. Although our study has some strengths, we cannot finally conclude on therapeutical implications in individuals with subclinical thyroid diseases.

scholarly journals Subclinical hyperthyroidism and blood pressure in a population-based prospective cohort study

2009 ◽  
Vol 161 (4) ◽  
pp. 615-621 ◽  
Author(s):  
Henry Völzke ◽  
Till Ittermann ◽  
Carsten O Schmidt ◽  
Marcus Dörr ◽  
Ulrich John ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Pulse Pressure ◽  
Prospective Cohort ◽  
Pressure Pulse ◽  
Population Based ◽  
Subclinical Hyperthyroidism ◽  
Serum Tsh ◽  
Tsh Levels

ObjectivesThere is current controversy on the association between subclinical hyperthyroidism and hypertension. Data from cohort studies have not been available yet. The present study was designed to longitudinally investigate possible associations of subclinical hyperthyroidism with blood pressure, pulse pressure and the risk of hypertension.MethodsWe used data from the population-based, prospective cohort Study of Health in Pomerania and included 2910 subjects (1469 women) aged 20–79 years with completed 5-year examination follow-up. Subjects with increased serum TSH levels or overt hyperthyroidism were excluded. Serum TSH levels below 0.25 mIU/l with free triiodothyronine and free thyroxine levels within the reference range were defined as subclinical hyperthyroidism. Blood pressure was measured according to standard methods.ResultsMultivariable analyses adjusted for age, sex, overweight, obesity, smoking status and time between the examinations did not reveal any statistically significant association between subclinical hyperthyroidism and any of the blood pressure-related variables in the whole study population. Although the 5-year hypertension incidence was higher in subjects with subclinical hyperthyroidism compared with those without (31.4 vs 19.2%; risk ratio 1.64; 95% confidence interval (CI) 1.17–2.28, P=0.006), both groups did not differ with respect to the risk of hypertension, after analyses were adjusted for confounders (relative risk 1.23, 95% CI 0.91–1.68, P=0.182). Analyses yielded similar results in subjects without thyroid disease and in those who took no antihypertensive medication.ConclusionSubclinical hyperthyroidism is not associated with changes in blood pressure, pulse pressure or incident hypertension.

scholarly journals Associations between thyroid function and mortality: the influence of age

2014 ◽  
Vol 171 (2) ◽  
pp. 183-191 ◽  
Author(s):  
Annenienke C van de Ven ◽  
Romana T Netea-Maier ◽  
Femmie de Vegt ◽  
H Alec Ross ◽  
Fred C G J Sweep ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Age Groups ◽  
Population Based ◽  
Normal Range ◽  
Population Based Study ◽  
Middle Range ◽  
The Relationship ◽  
Subclinical Thyrotoxicosis ◽  
Tsh Levels

ObjectiveThe aim of this study was to investigate the influence of age on the association between thyroid function and mortality.DesignThe Nijmegen Biomedical Study is a population-based study, comprising 5816 randomly selected adults of all age groups without previously known thyroid disease.MethodsTSH, free thyroxine (FT4) and peroxidase antibodies were measured in 2002–2003. The number of deaths were established in 2012 (median follow-up time 9.4 years).ResultsSubclinical thyrotoxicosis was associated with mortality in subjects aged <65 years (hazard ratio (HR) 2.5, 95% CI 1.1–5.7), but not in subjects aged >65 years. As for thyroid function within the normal range: in the 493 participants aged 80 years or older, an FT4 level in the high-normal range (18.5–22 pmol/l) was associated with a higher mortality in comparison with FT4 levels in the middle range (11.5–15.0 pmol/l): HR 1.7 (95% CI 1.0–2.9). In these elderly, TSH levels within the high-normal range (3.0–4.0 mIU/l) were also associated with a higher mortality in comparison with TSH levels within the middle range (1.0–2.0 mIU/l): HR 1.8 (95% CI 1.0–3.1).ConclusionsThe relationship between thyroid function and mortality differs according to age. This finding might (partially) explain the discrepant results of previous studies examining the relationship between thyroid function and mortality in different age groups.

scholarly journals TSH levels associated with slimming pill use in a population-based study of brazilian women

2007 ◽  
Vol 51 (9) ◽  
pp. 1448-1451 ◽  
Author(s):  
Rosely Sichieri ◽  
Roseli Andrade ◽  
Jader Baima ◽  
Jodelia Henriques ◽  
Mario Vaisman
Keyword(s):  
Body Mass Index ◽  
Multivariate Regression ◽  
Population Based ◽  
P Value ◽  
Socioeconomic Level ◽  
Obese Women ◽  
Regression Analyses ◽  
Population Based Study ◽  
Frequency Of Use ◽  
Tsh Levels

OBJECTIVE: To determine the consumption of slimming pills (SP) and its association with TSH levels. RESEARCH METHODS AND PROCEDURES: A survey was carried out in Rio de Janeiro (about 5 million inhabitants), Brazil, from June 2004 to April 2005. Households (1,500) were selected using three-stage probability sampling. Women were asked about use of SP, and blood sample was collected. Women were classified as users of SP any time in life, but not in previous two months (n = 293), current users (n = 150), and never users (n = 853). Weighted multivariate regression analyses compared TSH levels among these groups of users. RESULTS: The frequency of use of SP any time in life was 34% and the use in the previous two months was 11%. Both frequencies were greater among younger and obese women, and among those of high socioeconomic level (p-value < 0.001). TSH level was statistically lower among current users of SP (1.96 mUI/ml; 95%CI = 1.93-1.98) compared to previous users 2.83 mUI/ml (95%CI = 2.13-3.02) and never users 2.59 mUI/ml (95%CI = 2.20-3.21). These differences were still statistically significant after adjusting for age and body mass index. CONCLUSIONS: Use of SP decreased TSH levels among Brazilian women.

Treatment pattern and frequency of serum TSH measurement in users of different levothyroxine formulations: a population-based study during the years 2009–2015

Endocrine ◽  
2017 ◽  
Vol 58 (1) ◽  
pp. 143-152 ◽  
Author(s):  
Rosarita Ferrara ◽  
Valentina Ientile ◽  
Vincenzo Arcoraci ◽  
Carmen Ferrajolo ◽  
Carlo Piccinni ◽  
...  
Keyword(s):  
Population Based ◽  
Treatment Pattern ◽  
Population Based Study ◽  
Serum Tsh

scholarly journals Age-specific associations of serum TSH levels with markers of body composition in two population-based studies

2020 ◽  
Author(s):  
Till Ittermann ◽  
Marcello Markus ◽  
Martin Bahls ◽  
Stephan Felix ◽  
Antje Steveling ◽  
...  
Keyword(s):  
Body Composition ◽  
Waist Circumference ◽  
Interaction Analysis ◽  
Cell Mass ◽  
Population Based ◽  
Thyroid Stimulating Hormone ◽  
Fat Free Mass ◽  
Independent Population ◽  
Serum Tsh ◽  
Tsh Levels

Abstract Previous studies on the association between thyroid function and body composition are conflicting and showed strong differences across age groups. Our aim was to clarify age-specific associations of serum thyroid-stimulating hormone (TSH) levels with markers of body composition including body mass index (BMI), waist circumference, fat mass (FM), fat-free mass (FFM) and body cell mass (BCM). We used data from two independent population-based cohorts within the framework of the Study of Health in Pomerania (SHIP). The study population included 5,656 individuals aged 20 to 90 years. Markers of body composition were measured by bioelectrical impedance analysis. Serum TSH levels were significantly positively associated with BMI (β=0.16; 95% confidence interval [CI]: 0.06 to 0.27), waist circumference (β=0.35; 95% CI: 0.08 to 0.62) and FM (β=0.32; 95% CI: 0.12 to 0.52), but not with FFM an BCM. Interaction analysis revealed positive associations of serum TSH levels with BMI, waist circumference, FM, FFM and BCM in individuals older than 60 years, while no such associations were observed in younger individuals. We demonstrated that lower serum TSH levels were accompanied with lower values of BMI, waist circumference, FM, FFM, and BCM in the elderly, while no such associations were observed in younger individuals.

scholarly journals Thyroid function and the metabolic syndrome in older persons: a population-based study

2013 ◽  
Vol 168 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Nathalie E Heima ◽  
E Marelise W Eekhoff ◽  
Mirjam M Oosterwerff ◽  
Paul T A Lips ◽  
Natasja M van Schoor ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Representative Sample ◽  
Older Persons ◽  
Population Based ◽  
Population Based Study ◽  
The Metabolic Syndrome ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study ◽  
Serum Tsh

BackgroundStudies suggest an association between a high TSH and (individual components of) the metabolic syndrome. Only a few studies have been performed in the general older population.ObjectiveThis study investigates the association between serum TSH and the metabolic syndrome in a representative sample of older persons in The Netherlands.Design and patientsData of the Longitudinal Aging Study Amsterdam were used, which is an ongoing cohort study in a representative sample of Dutch older persons. A total of 1187 subjects (590 men and 597 women) between the ages of 65 and 88 years participated in the study.MeasurementsMetabolic syndrome (US National Cholesterol Education Program definition) and its individual components were assessed, as well as serum TSH levels.ResultsAmong the participants, the prevalence of the metabolic syndrome was 34.2%. The mean serum TSH was 1.9 mU/l. Subjects in the upper quartile with a serum TSH level above 2.28 mU/l (odds ratio (OR)=1.68; 95% confidence interval (CI) 1.19–2.37) had a significantly increased prevalence of metabolic syndrome compared with subjects in the lowest quartile with a serum TSH below 1.04 mU/l. After adjustment for confounders, age, sex, alcohol use, total physical activity, and smoking, the OR was 1.62 (95% CI 1.15–2.32).ConclusionsSubjects with a serum TSH in the upper quartile have a higher prevalence of metabolic syndrome as compared with subjects with a serum TSH in the lowest quartile.

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