scholarly journals Early effects of roflumilast on insulin sensitivity in adults with prediabetes and overweight/obesity involve age-associated fat mass loss – results of an exploratory study

2019 ◽  
Vol Volume 12 ◽  
pp. 743-759
Author(s):  
Ijeoma M Muo ◽  
Sandra D MacDonald ◽  
Ritu Madan ◽  
Sung-Jun Park ◽  
Ahmed M Gharib ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Mass Loss ◽  
Fat Mass ◽  
Exploratory Study ◽  
Early Effects ◽  
Fat Mass Loss

scholarly journals Intermittent Fasting and Fat Mass: What Is the Clinical Magnitude?

Obesities ◽  
2022 ◽  
Vol 2 (1) ◽  
pp. 1-7
Author(s):  
Heitor O. Santos
Keyword(s):  
Mass Loss ◽  
Fat Mass ◽  
Clinical Studies ◽  
Recent Literature ◽  
Energy Restriction ◽  
Intermittent Fasting ◽  
Reasonable Approach ◽  
Treatment Of Obesity ◽  
One Year ◽  
Fat Mass Loss

Clinical studies addressing the benefits of intermittent fasting (IF) diets have evoked interest in the treatment of obesity. Herein, the overall effects of IF regimens on fat-mass loss are explained in a brief review through a recent literature update. To date, human studies show a reduction in fat mass from 0.7 to 11.3 kg after IF regimens, in which the duration of interventions ranges from two weeks to one year. In light of this, IF regimens can be considered a reasonable approach to weight (fat mass) loss. However, the benefits of IF regimens occur thanks to energy restriction and cannot hence be considered the best dietary protocol compared to conventional diets.

Abstract 17361: How Leptin Harms the Heart in High Fat Diet-Induced Obesity

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Maria Pini
Keyword(s):  
Body Weight ◽  
Mass Loss ◽  
Fat Mass ◽  
High Fat Diet ◽  
Cardiac Fibroblasts ◽  
High Fat ◽  
Wide Range ◽  
Plasma Leptin ◽  
Fat Mass Loss

Introduction: Sedentary lifestyle and excessive calorie intake are risk factors for CVD. We have demonstrated the cardioprotective effect of exercise in aged mice and the critical role of visceral adiposity and its profibrotic secretome in increasing cardiovascular risks in obesity and aging. The association between exercise, lowered plasma leptin and reduced inflammatory leukocytes has been recently shown in patients with atherosclerosis. It remains unclear whether elevated plasma leptin can preserve or alter cardiovascular function in obesity. Methods: We analyzed the effect of high fat diet (HFD) in C57BL/6J male mice on the heart in terms of function, structure, histology and key molecular markers. Two interventions were used: 1) active fat mass loss via exercise (daily swimming) during HFD; 2) passive fat mass loss via surgical removal of the visceral adipose tissue (VAT lipectomy) followed by HFD. Results: HFD increased body weight and adiposity, leading to higher plasma leptin, glucose and insulin levels, compared to control diet (CD) mice. HFD impaired left ventricle (LV) structure (hypertrophy, interstitial fibrosis) and cardiac function (echocardiography, in vivo hemodynamics). Atria of HFD mice had enhanced pro-inflammatory protein production. Exercise reduced circulating leptin levels in HFD mice by 50%, in line with fat mass loss. In contrast, lipectomy reduced visceral fat mass, but body weight, adiposity and plasma leptin did not change. Both exercise and VAT lipectomy improved cardiac contractility, reversed collagen deposition and oxidative stress in HFD mice. Both interventions downregulated LV pro-inflammatory markers. We proved the role of leptin in cardiac remodeling in vitro by incubating primary cardiac fibroblasts with hyperleptinemic plasma from HFD mice. Remarkably, plasma from HFD-EX (exercise) suppressed the fibro-proliferative and pro-inflammatory responses of cardiac fibroblasts. Conclusions: Leptin directly contribute to cardiac fibrosis in obesity via activation and proliferation of cardiac fibroblasts. Understanding how leptin signals to the heart might have implications in a wide range of CVD, potentially helping early stratification and personalized care.

Exercise type and fat mass loss regulate breast cancer-related sex hormones in obese and overweight postmenopausal women

2020 ◽  
Vol 120 (6) ◽  
pp. 1277-1287
Author(s):  
Paola Gonzalo-Encabo ◽  
David Valadés ◽  
Natalio García-Honduvilla ◽  
Ana de Cos Blanco ◽  
Christine M. Friedenreich ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mass Loss ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Fat Mass ◽  
Exercise Type ◽  
Fat Mass Loss

Serum Cystatin C in Relation to Fat Mass Loss After Bariatric Surgery"

2012 ◽  
Vol 84 (4) ◽  
Author(s):  
Tomasz Śledziński ◽  
Monika Proczko-Markuszewska ◽  
Łukasz Kaska ◽  
Tomasz Stefaniak ◽  
Julian Świerczyński
Keyword(s):  
Bariatric Surgery ◽  
Mass Loss ◽  
Cystatin C ◽  
Fat Mass ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Fat Mass Loss

Carnitine Supplementation Fails to Maximize Fat Mass Loss Induced by Endurance Training in Rats

2004 ◽  
Vol 48 (2) ◽  
pp. 90-94 ◽  
Author(s):  
Marcelo Saldanha Aoki ◽  
André Luís Rodriguez Amaral Almeida ◽  
Francisco Navarro ◽  
Luís Fernando Bicudo Pereira Costa-Rosa ◽  
Reury Frank Pereira Bacurau
Keyword(s):  
Mass Loss ◽  
Endurance Training ◽  
Fat Mass ◽  
Carnitine Supplementation ◽  
Fat Mass Loss
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