scholarly journals Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling

2015 ◽  
pp. 6303 ◽  
Author(s):  
Yongfang Yuan ◽  
Yuanyuan Wang ◽  
Rong Wang ◽  
Yujie Wang ◽  
Ruqin Peng ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
P38 Mapk ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Nf Kappa B ◽  
I Kappa B Alpha

Ginkgo biloba extract alleviates liver fibrosis induced by CCl4 in rats

2005 ◽  
Vol 25 (6) ◽  
pp. 1224-1232 ◽  
Author(s):  
Jian Ding ◽  
Jieping Yu ◽  
Chengdang Wang ◽  
Wei Hu ◽  
Dan Li ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract

scholarly journals Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway

2018 ◽  
Vol Volume 12 ◽  
pp. 1281-1292 ◽  
Author(s):  
Rong Wang ◽  
Jing Wang ◽  
Fuxing Song ◽  
Shengnan Li ◽  
Yongfang Yuan
Keyword(s):  
Liver Fibrosis ◽  
Signaling Pathway ◽  
Nf Kappa B ◽  
I Kappa B Alpha

scholarly journals Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways

2018 ◽  
Vol Volume 12 ◽  
pp. 3595-3605 ◽  
Author(s):  
Jie Fan ◽  
Qingshan Chen ◽  
Liwen Wei ◽  
Xiaoming Zhou ◽  
Rong Wang ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Signaling Pathways ◽  
Asiatic Acid ◽  
Nf Kappa B ◽  
I Kappa B Alpha ◽  
Stat3 Signaling

scholarly journals Ginkgo biloba extract reverses CCl4–induced liver fibrosis in rats

2004 ◽  
Vol 10 (7) ◽  
pp. 1037 ◽  
Author(s):  
Yan-Jun Luo ◽  
Jie-Ping Yu ◽  
Zhao-Hong Shi ◽  
Li Wang
Keyword(s):  
Liver Fibrosis ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract

scholarly journals Therapeutic Effects and Molecular Mechanisms of Ginkgo Biloba Extract on Liver Fibrosis in Rats

2006 ◽  
Vol 34 (01) ◽  
pp. 99-114 ◽  
Author(s):  
Shi-Quan Liu ◽  
Jie-Ping Yu ◽  
Hong-Lei Chen ◽  
He-Sheng Luo ◽  
Shi-Ming Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Fibrosis ◽  
Ginkgo Biloba ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Stellate Cell ◽  
Ginkgo Biloba Extract ◽  
Therapeutic Effects ◽  
Dependent Manner ◽  
Mobility Shift

Oxidative stress can be implicated as a cause of liver fibrosis. In this sense, Ginkgo Biloba Extract (EGB), an antioxidant, may be beneficial in restraining liver fibrosis. The aim of this study was to evaluate the effects of EGB on experimental liver fibrosis. Rat liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride ( CCl 4) twice a week for 8 weeks. Three groups of rats received EGB (0.25, 0.5 and 1.0 g/kg, respectively) by stomach everyday. CCl 4 administration induced liver fibrosis, which was inhibited by EGB in a dose-dependent manner. The histopathologic score of fibrosis, liver function and the levels of plasma hyaluronic acid (HA) and laminin (LN) were significantly improved in rats treated with CCl 4 + EGB , compared with those treated with CCl 4 only ( p < 0.01 or p < 0.05). The activities of superoxide dismutase (SOD) and glutathione pero xidase (GSH-Px) were notably elevated, while malondialdehyde (MDA) content was significantly decreased in the rats treated with CCl 4 + EGB ( p < 0.01 or p < 0.05). Inhibition of hepatic stellate cell (HSC) activation and nuclear factor kappaBP65 (NF-κBP65) expression was demonstrated in the livers of EGB-treated rats. The activation of NF-κB was significantly suppressed in EGB-treated rats determined by electrophoretic mobility shift assay (EMSA). Furthermore, EGB reduced expressions of transforming growth factor-β1 (TGF-β1) and collagen I mRNA. In conclusion, EGB is able to ameliorate liver injury and prevent rats from CCl 4-induced liver fibrosis by suppressing oxidative stress. This process may be related to inhibiting the induction of NF-κB on HSC activation and the expression of TGF-β1.

Quality Control Optimization Solutions for Determination of Rutin in Supplements Containing Ginkgo Biloba Extract

2016 ◽  
Vol 12 (4) ◽  
pp. 386-390 ◽  
Author(s):  
Ivanka P. Pencheva ◽  
Vania N. Maslarska ◽  
Assena C. Stoimenova ◽  
Manoela M. Manova ◽  
Lily A. Andonova ◽  
...  
Keyword(s):  
Quality Control ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Control Optimization

Quantitative GC-FID and UHPLC-DAD Evaluation of Bioactive Compounds Extracted from Ginkgo biloba

2020 ◽  
Vol 16 (7) ◽  
pp. 893-904
Author(s):  
Alessandra von Ahn ◽  
João Henrique Z. dos Santos
Keyword(s):  
Ginkgo Biloba ◽  
Extraction Efficiency ◽  
Extraction Methods ◽  
Ginkgo Biloba Extract ◽  
Previous Method ◽  
Array Detector ◽  
Ginkgolide B ◽  
Detection Techniques ◽  
Ginkgolide A ◽  
Terpene Trilactones

Background: The official compendium of the quantification of ginkgo flavonoids from Ginkgo biloba extract has been proposed using HPLC. The drawbacks of this technique appear to be due to the restricted efficiency in terms of the recovery results and suitability of the system for the quantification of these compounds. This study investigated the potential advantages and limitations of the development of efficient extraction methods for the recovery of flavonol glycosides (quercetin, kaempferol and isorhamnetin) and terpene trilactones (bilobalide, ginkgolide A, ginkgolide B and ginkgolide C) using extraction, quantification and detection techniques, namely, GC-FID and UHPLC-DAD, which are alternatives to those techniques available in the literature. Methods: Two different extraction methodologies have been developed for the determination of flavonoids (quercetin, kaempferol and isorhamnetin) and terpene trilactones (bilobalide, ginkgolide A, ginkgolide B and ginkgolide C) using ultra-high-pressure liquid chromatography coupled to a diode array detector and gas chromatography coupled to a flame ionization detector. Results: In this study, the Ginkgo biloba extract mass, hydrolysis preparation method (with or without reflux), and volume of the extraction solution seemed to affect the ginkgo flavonoid recovery. The UHPLC-based method exhibited higher extraction efficiency for ginkgo flavonoid quantification compared to the pharmacopoeial method. The developed method exhibited higher extraction efficiency for terpene quantification compared to the previous method that used extractive solution without pH adjustment, with less time of extraction and less amount of the sample and organic solvent aliquots. Conclusion: The UHPLC and GC analysis methods established in this study are both effective and efficient. These methods may improve the quality control procedures for ginkgo extract and commercial products available in today´s natural health product market. The results indicate that redeveloped extraction methods can be a viable alternative to traditional extraction methods.

Sign in / Sign up

Export Citation Format

Share Document