scholarly journals Preparation and characterization of silymarin synchronized-release microporous osmotic pump tablets

2016 ◽  
pp. 519
Author(s):  
Hong-tao Song ◽  
Qi-ping Zeng ◽  
Zhi-hong Liu ◽  
Ai-wen Huang ◽  
Jing Zhang
Keyword(s):  
Osmotic Pump ◽  
Synchronized Release

DEVELOPMENT AND CHARACTERIZATION OF ELEMENTARY OSMOTIC PUMP TABLETS FOR SIMULTANEOUS RELEASE OF METFORMIN AND GLIPIZIDE

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (11) ◽  
pp. 19-29
Author(s):  
P Bharadwaj ◽  
◽  
P. K Upaddhyay ◽  
V Agarwal ◽  
D Chaurasia ◽  
...  
Keyword(s):  
Controlled Release ◽  
Release Profile ◽  
Osmotic Pump ◽  
Dependent Diabetes Mellitus ◽  
Wet Granulation ◽  
Type Ii ◽  
Surface Porosity ◽  
Before And After ◽  
Method Effects

The aim of present study was to design and evaluate an elementary osmotic pump-based drug delivery system for controlled release of metformin and glipizide simultaneously for treatment of type II noninsulin dependent diabetes mellitus. Inclusion complex of glipizide with β- cyclodextrin was prepared to enhance its solubility. Core tablets were prepared by wet granulation method. Effects of different variables like amount of plasticizer, osmogen, orifice size and dissolution media were studied on release profile for both drugs. Morphology of semi permeable was studied using electron microscope before and after dissolution test. On increasing the amount of osmogen, the release of both drugs was found to be increased. No significant effect of PVP K 30 was observed on drug release. Optimization results indicated that the release of both drugs was directly proportional to the surface porosity of the membrane. It was concluded that the osmotic pump tablets could provide more prolonged and controlled release that may result in an improved therapeutic efficacy and patient compliance.

Characterization of Prednisolone in Controlled Porosity Osmotic Pump Pellets using Solid-State NMR Spectroscopy

2007 ◽  
Vol 96 (5) ◽  
pp. 1008-1017 ◽  
Author(s):  
S. Sotthivirat ◽  
J.W. Lubach ◽  
J.L. Haslam ◽  
E.J. Munson ◽  
V.J. Stella
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Solid State Nmr ◽  
Osmotic Pump ◽  
Solid State Nmr Spectroscopy ◽  
Controlled Porosity

Morphological Characterization of Mycobacteriophage R1

1974 ◽  
Vol 32 ◽  
pp. 254-255
Author(s):  
B. L. Soloff ◽  
T. A. Rado
Keyword(s):  
Carbon Source ◽  
Stationary Phase ◽  
Growth Phase ◽  
Minimal Medium ◽  
Morphological Characterization ◽  
Logarithmic Growth Phase ◽  
Complete Lysis ◽  
Lysogenic Culture ◽  
Logarithmic Growth

Mycobacteriophage R1 was originally isolated from a lysogenic culture of M. butyricum. The virus was propagated on a leucine-requiring derivative of M. smegmatis, 607 leu−, isolated by nitrosoguanidine mutagenesis of typestrain ATCC 607. Growth was accomplished in a minimal medium containing glycerol and glucose as carbon source and enriched by the addition of 80 μg/ ml L-leucine. Bacteria in early logarithmic growth phase were infected with virus at a multiplicity of 5, and incubated with aeration for 8 hours. The partially lysed suspension was diluted 1:10 in growth medium and incubated for a further 8 hours. This permitted stationary phase cells to re-enter logarithmic growth and resulted in complete lysis of the culture.

AEM analysis of crystallization in Ti-based amorphous alloys

1983 ◽  
Vol 41 ◽  
pp. 270-271
Author(s):  
A.R. Pelton ◽  
A.F. Marshall ◽  
Y.S. Lee
Keyword(s):  
Magnetic Properties ◽  
Amorphous Alloys ◽  
Amorphous Materials ◽  
Isothermal Annealing ◽  
Amorphous Matrix ◽  
Nucleation And Growth ◽  
Current Interest ◽  
Amorphous Films ◽  
Electrical And Magnetic Properties

Amorphous materials are of current interest due to their desirable mechanical, electrical and magnetic properties. Furthermore, crystallizing amorphous alloys provides an avenue for discerning sequential and competitive phases thus allowing access to otherwise inaccessible crystalline structures. Previous studies have shown the benefits of using AEM to determine crystal structures and compositions of partially crystallized alloys. The present paper will discuss the AEM characterization of crystallized Cu-Ti and Ni-Ti amorphous films.Cu60Ti40: The amorphous alloy Cu60Ti40, when continuously heated, forms a simple intermediate, macrocrystalline phase which then transforms to the ordered, equilibrium Cu3Ti2 phase. However, contrary to what one would expect from kinetic considerations, isothermal annealing below the isochronal crystallization temperature results in direct nucleation and growth of Cu3Ti2 from the amorphous matrix.

Characterization of Coherent, Ordered Precipitates in Nickel-Base Alloys

1973 ◽  
Vol 31 ◽  
pp. 144-145
Author(s):  
B. H. Kear ◽  
J. M. Oblak
Keyword(s):  
Stable Phase ◽  
Nickel Base Superalloy ◽  
Alloy 718 ◽  
Commercial Alloy ◽  
Precipitate Morphology ◽  
Continuous Precipitation ◽  
Nickel Base ◽  
Base Superalloy ◽  
Strengthening Precipitate

A nickel-base superalloy is essentially a Ni/Cr solid solution hardened by additions of Al (Ti, Nb, etc.) to precipitate a coherent, ordered phase. In most commercial alloy systems, e.g. B-1900, IN-100 and Mar-M200, the stable precipitate is Ni3 (Al,Ti) γ′, with an LI2structure. In A lloy 901 the normal precipitate is metastable Nis Ti3 γ′ ; the stable phase is a hexagonal Do2 4 structure. In Alloy 718 the strengthening precipitate is metastable γ″, which has a body-centered tetragonal D022 structure.Precipitate MorphologyIn most systems the ordered γ′ phase forms by a continuous precipitation re-action, which gives rise to a uniform intragranular dispersion of precipitate particles. For zero γ/γ′ misfit, the γ′ precipitates assume a spheroidal.

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