scholarly journals A novel in situ gel base of deacetylase gellan gum for sustained ophthalmic drug delivery of ketotifen: in vitro and in vivo evaluation

2015 ◽  
pp. 3943 ◽  
Author(s):  
Peiling Li ◽  
Lina Zhu ◽  
Junping Ao
Keyword(s):  
Drug Delivery ◽  
Gellan Gum ◽  
In Vivo Evaluation ◽  
In Situ Gel ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

scholarly journals FORMULATION, OPTIMIZATION, AND EVALUATION OF IN-SITU GEL OF MOXIFLOXACIN HYDROCHLORIDE FOR OPHTHALMIC DRUG DELIVERY

2019 ◽  
pp. 147-158
Author(s):  
Chitra Gupta ◽  
VIJAY JUYAL ◽  
Upendra Nagaich
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Influential Factors ◽  
Drug Formulation ◽  
In Situ Gel ◽  
Formulation Optimization ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Objective: The present study emphasizes the synthesis, optimization, and evaluation of ocular in-situ gel for ophthalmic drug delivery against conjunctivitis. Methods: Pre-formulation studies on the drug and polymers were carried out, which included the study of various physicochemical properties of the drug and drug-polymer compatibility studies. The 12 different formulations were further pre-optimised by Taguchi method for determining the number of influential factors. Furthermore, the formulation optimization was done by using ‘Box–Behnken’ design (BBD) (Design expert 10 software) for assessing the effect of formulation variables on product characteristics viz. viscosity, gelation temperature (GT), and mean release time (MRT). About 13 suggested runs of the experiment were carried out and formulations were optimised. Finally, three batches of the optimised formulation were prepared and evaluated for in vitro drug release, isotonicity of formulation, anti-microbial potential, ocular irritancy, and accelerated stability testing. Results: Pre-formulation study confirmed the purity, solubility, and compatibility of drug measured by λmax, partition coefficient, stability study, and Fourier-transform infrared spectroscopy (FTIR) analysis. Taguchi screening method suggested about 12 different formulations and 3 most prominent influential factors including viscosity, GT, and drug release. 13 different formulations designed based on ‘BBD’ method were further optimised by considering the most influential factors suggested by Taguchi screening. The in vitro evaluation of the optimised formulation gave satisfactory results in terms of drug release, and anti-microbial activity. It was found to be isotonic with no ocular irritancy. Further, the preparation immediately transformed from sol to gel upon administration into cul-de-sac region of the eye due to multi-dimensional approaches utilised for in-situ gel formation namely temperature change Pluronic, ion sensitivity due to Gellan-gum, pH sensitivity because of Carbopol. Conclusion: The optimised in-situ gelling ocular drug formulation showed promising potency for ophthalmic drug delivery with no irritancy due to the multifactorial mechanism.

scholarly journals DEVELOPMENT, EVALUATION AND CHARACTERISTICS OF OPHTHALMIC IN SITU GEL SYSTEM: A REVIEW

2019 ◽  
pp. 47-53 ◽  
Author(s):  
MRINMOY DEKA ◽  
ABDUL BAQUEE AHMED ◽  
JASHOBIR CHAKRABORTY
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Temperature Modulation ◽  
Duration Of Action ◽  
In Situ Gel ◽  
Ophthalmic Drug Delivery ◽  
Sensitive Organ ◽  
Ophthalmic Drug

Eye is a sensitive organ and is easily injured and infected. Delivery of drugs into eye is complicated due to removal mechanism of precorneal area results decrease in therapeutic response. Conventional ocular delivery systems like solution, suspension, ointment shows some disadvantages such as rapid corneal elimination, repeated instillation of drug and short duration of action. In situ polymeric delivery system will help to achieve optimal concentration of drug at the target site, thereby helps to achieve the desired therapeutic concentration. There are various novel ocular drug delivery systems such as In-situ gel, dendrimers, niosomes, nanoparticulate system, collagen shield, ocular iontophoresis suspension and ocusert etc. In situ gelling systems are liquid upon instillation and undergo a phase transition to form gel due to some stimuli responses such as temperature modulation, change in pH and presence of ions. Various attempts have been made towards the development of stable sustained release in-situ gels. Newer research in ophthalmic drug delivery systems is directed towards an incorporation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. This is a review based on ocular in situ gels, characteristization, techniques and evaluation of in situ ophthalmic drug delivery systems,

A Review on In Situ gel forming ophthalmic drug delivery systems

2018 ◽  
Vol 11 (1) ◽  
pp. 380
Author(s):  
Harsha Vardhani Kondepati ◽  
Girish Pai Kulyadi ◽  
Vamshi Krishna Tippavajhala
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Situ Gel ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

In vitro and in vivo evaluation of an in situ gel forming system for the delivery of PEGylated octreotide

2013 ◽  
Vol 48 (1-2) ◽  
pp. 87-96 ◽  
Author(s):  
Laleh Erfani Jabarian ◽  
Mohammad Reza Rouini ◽  
Fatemeh Atyabi ◽  
Alireza Foroumadi ◽  
Seyed Mahdi Nassiri ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
In Situ Gel

scholarly journals Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

2016 ◽  
pp. 405 ◽  
Author(s):  
Khalid M. El-Say ◽  
Yasser Alharby ◽  
Abdel-Rahim El-Helw ◽  
Khaled M. Hosny ◽  
Tarek Ahmed
Keyword(s):  
In Vivo Evaluation ◽  
In Situ Gel

scholarly journals An Insight into Ophthalmic Drug Delivery System

2009 ◽  
Vol 1 (01) ◽  
Author(s):  
Rathore K. S. ◽  
Nema R. K.
Keyword(s):  
Drug Delivery ◽  
Topical Administration ◽  
Eye Drops ◽  
In Situ Gel ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Ophthalmic Therapy ◽  
Ocular Therapy ◽  
Insight Into

Promising management of eye ailments take off effective concentration of drug at the eye for sufficient period of time. Dosage forms are administered directly to eye for localized ophthalmic therapy. Most of the treatments call for the topical administration of ophthalmic active drugs to the tissues around the ocular cavity. Conventional ophthalmic drug delivery systems including eye drops, ophthalmic ointments, are no longer sufficient to encounter eye diseases. This article reviews the constraints with conventional ocular therapy and explores various novel approaches like in-situ gel, ocular films or ocuserts, nanosuspension, collagen shields, latex systems, nanoparticles, liposomes, niosomes, iontophorosis, eye implants, etc to improve the ophthalmic bioavailability of drugs to the anterior chamber of the eye.

New Mucoadhesive Chitosan Film for Ophthalmic Drug Delivery of Timolol Maleate: In Vivo Evaluation

2012 ◽  
Vol 28 (4) ◽  
pp. 350-358 ◽  
Author(s):  
Gustavo de Oliveira Fulgêncio ◽  
Fernando Antônio Bretas Viana ◽  
Raul Rio Ribeiro ◽  
Maria Irene Yoshida ◽  
André Gomes Faraco ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chitosan Film ◽  
Timolol Maleate ◽  
In Vivo Evaluation ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug
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