The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells

Drug Design Development and Therapy ◽

10.2147/dddt.s75378 ◽

2015 ◽

pp. 1627 ◽

Cited By ~ 16

Author(s):

Shu-Feng Zhou ◽

Jin-Ping Li ◽

Yin-Xue Yang ◽

Qi-Lun Liu ◽

Shuting Pan ◽

...

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Aurora Kinase ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Aurora Kinase A ◽

Kinase A

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Functional Significance of Aurora Kinase A Regulatory Interactions with p53–ERα Complex in Human Breast Cancer Cells

Hormones and Cancer ◽

10.1007/s12672-011-0070-x ◽

2011 ◽

Vol 2 (2) ◽

pp. 117-124 ◽

Cited By ~ 11

Author(s):

Hiroshi Katayama ◽

Subrata Sen

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Aurora Kinase ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Aurora Kinase A ◽

Regulatory Interactions ◽

Kinase A

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Mechanisms Underlying the Anti-Proliferative Actions of Adiponectin in Human Breast Cancer Cells, MCF7-Dependency on the cAMP/Protein Kinase-A Pathway

Nutrition and Cancer ◽

10.1080/01635581.2010.516472 ◽

2010 ◽

pp. 1-1 ◽

Cited By ~ 5

Author(s):

Gang Li ◽

Li Cong ◽

Jessica Gasser ◽

Jessica Zhao ◽

Ke Chen ◽

...

Keyword(s):

Breast Cancer ◽

Protein Kinase ◽

Protein Kinase A ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Kinase A

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Effects of Chinaberry Tree Extract on Proliferation, Apoptosis, Migration and Cell Cycle Distribution of Human Breast Cancer Cells

10.36468/pharmaceutical-sciences.spl.4 ◽

2020 ◽

Vol 20 (s2) ◽

Author(s):

X. Jian ◽

Xiao Chunhong ◽

C. Hongyan ◽

Lu Huijun ◽

Yu Haizhong ◽

...

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Cell Cycle Distribution ◽

Human Breast Cancer Cells ◽

Human Breast

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SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells

Anti-Cancer Drugs ◽

10.1097/cad.0000000000000826 ◽

2020 ◽

Vol 31 (1) ◽

pp. 35-43

Author(s):

Liany Luna-Dulcey ◽

James A. da Silva ◽

Marcia R. Cominetti

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Cell Death ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Migration And Invasion ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Cycle Arrest

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The Discodermia calyx Toxin Calyculin A Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells

Toxins ◽

10.3390/toxins3010105 ◽

2011 ◽

Vol 3 (1) ◽

pp. 105-119 ◽

Cited By ~ 8

Author(s):

Jessica R. Edelson ◽

David L. Brautigan

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Cell Cycle Progression ◽

Calyculin A ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Cycle Progression

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The Potentiation of Estrogen on Insulin-like Growth Factor I Action in MCF-7 Human Breast Cancer Cells Includes Cell Cycle Components

Journal of Biological Chemistry ◽

10.1074/jbc.m006741200 ◽

2000 ◽

Vol 275 (46) ◽

pp. 35893-35901 ◽

Cited By ~ 100

Author(s):

Joelle Dupont ◽

Michael Karas ◽

Derek LeRoith

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Growth Factor ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Factor I ◽

Mcf 7

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Abstract 574: α-santalol induces caspase-dependent apoptosis and G2/M phase cell cycle arrest in human breast cancer cells

10.1158/1538-7445.am2012-574 ◽

2012 ◽

Author(s):

Sreevidya Santha ◽

Ajay Bommareddy ◽

Brittny Rule ◽

Ruth Guillermo ◽

Radhey S. Kaushik ◽

...

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Phase Cell ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Cycle Arrest ◽

M Phase

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Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis

Scientific Reports ◽

10.1038/s41598-018-37796-w ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 26

Author(s):

Nursyamirah Abd Razak ◽

Nadiah Abu ◽

Wan Yong Ho ◽

Nur Rizi Zamberi ◽

Sheau Wei Tan ◽

...

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Cycle Arrest ◽

Induction Of Apoptosis ◽

Mcf 7

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Hypoxia- and radiation-induced overexpression of Smac by an adenoviral vector and its effects on cell cycle and apoptosis in MDA-MB-231 human breast cancer cells

Experimental and Therapeutic Medicine ◽

10.3892/etm.2013.1351 ◽

2013 ◽

Vol 6 (6) ◽

pp. 1560-1564 ◽

Cited By ~ 2

Author(s):

WEI-WU LIU ◽

YANG LIU ◽

SHUO LIANG ◽

JIA-HUI WU ◽

ZHI-CHENG WANG ◽

...

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Cancer Cells ◽

Human Breast Cancer ◽

Adenoviral Vector ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Radiation Induced

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Ganoderma lucidum Extract Induces G1 Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells

The American Journal of Chinese Medicine ◽

10.1142/s0192415x12500474 ◽

2012 ◽

Vol 40 (03) ◽

pp. 631-642 ◽

Cited By ~ 34

Author(s):

Guosheng Wu ◽

Zhengming Qian ◽

Jiajie Guo ◽

Dejun Hu ◽

Jiaolin Bao ◽

...

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Cycle Arrest ◽

G1 Cell Cycle Arrest ◽

Mcf 7

Ganoderma lucidum (Fr.) Karst is a traditional Chinese herb that has been widely used for centuries to treat various diseases including cancer. Herein, an ethanol-soluble and acidic component (ESAC), which mainly contains triterpenes, was prepared from G. lucidum and its anti-tumor effects in vitro were tested on human breast cancer cells. Our results showed that ESAC reduced the cell viability of MCF-7 and MDA-MB-231 cells in a concentration-dependent manner with IC50 of about 100 μg/mL and 60 μg/mL, respectively. DNA damage was detected by Comet assay and the increased expression of γ-H2AX after ESAC treatment was determined in MCF-7 cells. Moreover, ESAC effectively mediated G1 cell cycle arrest in both concentration- and time-dependent manners and induced apoptosis as determined by Hoechst staining, DNA fragment assay and Western blot analysis in MCF-7 cells. In conclusion, ESAC exerts anti-proliferation effects by inducing DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells.

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