scholarly journals Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients

2014 ◽  
pp. 2241
Author(s):  
Wooseong Huh ◽  
Hyunjeong Baek ◽  
Seunghoon Han ◽  
Dong-Seok Yim ◽  
Sung Joo Kim ◽  
...  
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Population Pharmacokinetics ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
State Population

scholarly journals Tacrolimus Population Pharmacokinetics and Multiple CYP3A5 Genotypes in Black and White Renal Transplant Recipients

2018 ◽  
Vol 58 (9) ◽  
pp. 1184-1195 ◽  
Author(s):  
Olivia Campagne ◽  
Donald E. Mager ◽  
Daniel Brazeau ◽  
Rocco C. Venuto ◽  
Kathleen M. Tornatore
Keyword(s):  
Renal Transplant ◽  
Population Pharmacokinetics ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Black And White

Steady-state concentration of cyclosporin G (OG37-325) and its metabolites in renal transplant recipients

1994 ◽  
Vol 40 (4) ◽  
pp. 613-616 ◽  
Author(s):  
L J Langman ◽  
A B Leichtman ◽  
W F Weitzel ◽  
R W Yatscoff
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Secondary Metabolites ◽  
Whole Blood ◽  
Relative Concentration ◽  
Cross Reactivity ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Dosing Interval ◽  
Trough Concentrations

Abstract The steady-state concentrations of cyclosporin G (OG37-325) (CsG) and six of its metabolites (GM1, GM9, GM4N, GM1c, GM1c9, GM19) were measured throughout the 12-h dosing interval in six renal transplant recipients receiving CsG as prophylaxis against acute cellular rejection. The mean 12-h whole-blood trough concentrations (micrograms/L) were CsG, 131 +/- 26; GM1, 79 +/- 55; GM9, 110 +/- 114; GM4N, 28 +/- 18; GM1c, 31 +/- 18; GM1c9, 216 +/- 145; and GM19, 303 +/- 217. The relative concentration of the primary metabolites (GM1, GM9, GM4N) remained stable with respect to CsG throughout the dosing interval, whereas that of the secondary metabolites increased. The secondary metabolites GM19 and GM1c9 exhibited extensive between-patient variation. We investigated the effect of these metabolites on commercially available monoclonal antibody-based fluorescence polarization immunoassays (FPIA) and RIAs adapted for measurement of CsG. The 12-h whole-blood trough concentrations measured by FPIA and RIA exceed those measured by HPLC by 19% and 36%, respectively. These measured biases corresponded closely with the calculated biases (FPIA 19%, RIA 28%) based on the known cross-reactivities of CsG metabolites and their concentrations. These results suggest that cross-reactivity with metabolites account for a large part of the bias observed in immunoassays of CsG.

The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients

2016 ◽  
Vol 55 (9) ◽  
pp. 1129-1143 ◽  
Author(s):  
Agnieszka A. Prytuła ◽  
Karlien Cransberg ◽  
Antonia H. M. Bouts ◽  
Ron H. N. van Schaik ◽  
Huib de Jong ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Population Pharmacokinetics ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Cyp3a5 Genotype

Effect of Cyclosporine on Steady-State Pharmacokinetics of MPA in Renal Transplant Recipients Is Not Affected by the MPA Formulation

2014 ◽  
Vol 36 (4) ◽  
pp. 456-464 ◽  
Author(s):  
Vladimir Trkulja ◽  
Zdenka Lalić ◽  
Sandra Nađ-Škegro ◽  
Ana Lebo ◽  
Paula Granić ◽  
...  
Keyword(s):  
Steady State ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Cyclosporine (Equoral®) Population Pharmacokinetics and Bayesian Estimation in Tunisian Renal Transplant Recipients

2015 ◽  
Vol 02 (02) ◽  
Author(s):  
Hanene Eljebari ◽  
Emna Gaïes ◽  
Mohamed Mongi Bacha ◽  
Jean-Baptist Woillard ◽  
Nadia Jebabli ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Bayesian Estimation ◽  
Population Pharmacokinetics ◽  
Renal Transplant Recipients ◽  
Transplant Recipients
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