scholarly journals Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability

2020 ◽  
Vol Volume 14 ◽  
pp. 2959-2975
Author(s):  
Pei Liu ◽  
Jian-yu Zhou ◽  
Jin-hua Chang ◽  
Xi-gang Liu ◽  
He-fei Xue ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
High Stability ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
High Solubility

Effect of supersaturation on the oral bioavailability of paclitaxel/polymer amorphous solid dispersion

2018 ◽  
Vol 9 (1) ◽  
pp. 344-356 ◽  
Author(s):  
Linlin Miao ◽  
Yuheng Liang ◽  
Wenli Pan ◽  
Jingxin Gou ◽  
Tian Yin ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion

To crush or not to crush: A brief review of novel tablets and capsules prepared from nanocrystal and amorphous solid dispersion technologies

2020 ◽  
Author(s):  
Elizabeth Uttaro ◽  
Madhu Pudipeddi ◽  
Anne Schweighardt ◽  
Fang Zhao
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Solid Dispersions ◽  
Healthcare Providers ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Accurate Information ◽  
Drug Products ◽  
Development Pipeline ◽  
New Formulation

Abstract Purpose To educate healthcare professionals regarding the risks of manipulating drug products formulated via nanocrystal or amorphous solid dispersion technologies. Summary Recent pharmaceutics innovations such as nanocrystals and amorphous solid dispersions have been used successfully to improve oral bioavailability of drugs. Over 30 drug products based on these technologies have been approved by the Food and Drug Administration, and more are in the development pipeline. While these products are similar in appearance to traditional tablets or capsules, they should not be crushed or suspended in liquid vehicles. Such manipulations can compromise the integrity of the formulation and subsequently alter the oral bioavailability. It is alarming that the majority of these products are not included in the Institute for Safe Medication Practices (ISMP) “Do Not Crush” list. A summary drug table is presented in this article to provide accurate information for pharmacists and other healthcare providers. Conclusion Novel formulations of tablets and capsules are being used to increase the oral bioavailability of certain drugs. Crushing these products can significantly alter product performance and clinical outcomes. We encourage ISMP to add these drug products to the Do Not Crush list due to wide use of this list throughout healthcare. In the meantime, pharmacists should be mindful of the new formulation technologies and advocate for the proper use of these drug products.

Development of High-Energy Amorphous Solid Dispersion of Nanosized Nobiletin, a Citrus Polymethoxylated Flavone, with Improved Oral Bioavailability

2011 ◽  
Vol 100 (9) ◽  
pp. 3793-3801 ◽  
Author(s):  
Satomi Onoue ◽  
Atsushi Uchida ◽  
Haruki Takahashi ◽  
Yoshiki Seto ◽  
Yohei Kawabata ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Amorphous Solid ◽  
High Energy ◽  
Amorphous Solid Dispersion
Sign in / Sign up

Export Citation Format

Share Document