scholarly journals Laquinimod Protects Against TNF-α-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs) by Increasing the Expression of KLF2

2020 ◽  
Vol Volume 14 ◽  
pp. 1683-1691
Author(s):  
Tiechao Jiang ◽  
Wenhao Zhang ◽  
Zhongyu Wang
Keyword(s):  
Endothelial Cells ◽  
Aortic Endothelial Cells ◽  
Tnf Α ◽  
Human Aortic Endothelial Cells ◽  
Aortic Endothelial

scholarly journals CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144133 ◽  
Author(s):  
Jennifer A. Greene ◽  
Jose-Andres C. Portillo ◽  
Yalitza Lopez Corcino ◽  
Carlos S. Subauste
Keyword(s):  
Endothelial Cells ◽  
Retinal Endothelial Cells ◽  
Aortic Endothelial Cells ◽  
Tnf Α ◽  
Human Aortic Endothelial Cells ◽  
Aortic Endothelial

Asiaticoside Inhibits TNF-α-Induced Endothelial Hyperpermeability of Human Aortic Endothelial Cells

2015 ◽  
Vol 29 (10) ◽  
pp. 1501-1508 ◽  
Author(s):  
Lai Yen Fong ◽  
Chin Theng Ng ◽  
Zainul Amiruddin Zakaria ◽  
Mohamad Taufik Hidayat Baharuldin ◽  
Abdul Kadir Arifah ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Aortic Endothelial Cells ◽  
Tnf Α ◽  
Human Aortic Endothelial Cells ◽  
Endothelial Hyperpermeability ◽  
Aortic Endothelial

Chios Mastic Gum Extract and Isolated Phytosterol Tirucallol Exhibit Anti-Inflammatory Activity in Human Aortic Endothelial Cells

2009 ◽  
Vol 234 (5) ◽  
pp. 553-561 ◽  
Author(s):  
Stella Loizou ◽  
Sotirios Paraschos ◽  
Sofia Mitakou ◽  
George P. Chrousos ◽  
Ioannis Lekakis ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Adhesion Molecules ◽  
U937 Cells ◽  
Aortic Endothelial Cells ◽  
Tnf Α ◽  
Chios Mastic Gum ◽  
Anti Inflammatory ◽  
The Impact ◽  
Human Aortic Endothelial Cells ◽  
Aortic Endothelial

Chios mastic gum (CMG) is a white, semitransparent, natural resin that is obtained as a trunk exudate from mastic trees. Triterpenic compounds and phytosterols like tirucallol are among its major components. CMG has been associated with cardiovascular protection, exerting its effect mainly through increasing the antioxidant defense system, and effectively lowering the levels of serum cholesterol in human subjects. However, data on its anti-inflammatory effect on endothelium are scarce. Attachment of leukocytes to the vascular endothelium and the subsequent migration of cells into the vessel wall are early events in atherogenesis, and this process requires the expression of endothelial adhesion molecules. In this study, we examined the effect of CMG neutral extract (25–200 μ g/ml) and tirucallol (0.1–100 μ M) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-α stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-α-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-α-stimulated HAEC and attenuate the phosphorylation of NFkB p65. This study extends existing data regarding the cardioprotective effect of CMG, expands the spectrum of known phytosterols with potent antiatheromatic activity, provides new insight into the mechanisms underlying the beneficial effect of CMG on endothelial function, and may aid in design of new therapy for intervention in atherosclerosis.

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