scholarly journals Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles

2020 ◽  
Vol Volume 14 ◽  
pp. 823-832 ◽  
Author(s):  
Junjian Wang
Keyword(s):  
Cervical Cancer ◽  
Combination Treatment ◽  
Ph Sensitive ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

scholarly journals pH Sensitive Lipid-Polymer Hybrid Nanoparticles Mediated Delivery of Docetaxel: A Viable Approach for Breast Cancer Therapeutic Intervention Development

2020 ◽  
Author(s):  
Ye Yuan ◽  
Jia-Xing Song ◽  
Mei-Na Zhang ◽  
Baoshan Yuan
Keyword(s):  
Breast Cancer ◽  
Cellular Uptake ◽  
Intervention Development ◽  
Ph Sensitive ◽  
Therapeutic Interventions ◽  
Hybrid Nanoparticles ◽  
Breast Cancer Cell Lines ◽  
Polymer Hybrid

Abstract Present study was planned for the development of pH sensitive lipid polymer hybrid nanoparticles (pHS-LPHNPs) loaded with docetaxel (DTX) for guided and target specific cytosolic-delivery delivery of docetaxel (DTX). pHS-LPHNPs were formulated to entrap DTX by self-assembled nano-precipitation technique and characterised with respect to zeta potential, particle-size, entrapment efficiency, PDI as well as invitro drug release. The cell viability, apoptosis, cellular-uptake, pharmacokinetics, bio-distribution in vital organs, % changes in tumour volume and survival of breast cancer bearing animals were used for the evaluation of efficacy of the formulation. In-vitro studies showed increased cytotoxicity at lower IC50 and better cellular-uptake of pHS-LPHNPs mediated drug by breast cancer cell lines. We saw the better rate of apoptosis of breast cancer cells via Annexin V/Propidium iodide staining. Moreover, in-vivo studies demonstrated improved pharmacokinetics and targetability with minimum drug circulation in deep-seated organs upon delivery of DTX via pHS-LPHNPs in comparison with LPHNPs-DTX and free DTX. We observed sizeable % reduction in tumour-burden with pHS-LPHNPs-DTXthan that withLPHNPs-DTX &free DTX. In brief, pHS-LPHNPs mediated delivery of DTX exhibited promising approach for developing therapeutic-interventions against breast-cancer.

scholarly journals pH Sensitive Lipid-Polymer Hybrid Nanoparticles Mediated Delivery of Docetaxel: A Viable Approach for Breast Cancer Therapeutic Intervention Development

2020 ◽  
Author(s):  
Ye Yuan ◽  
Jia-Xing Song ◽  
Mei-Na Zhang ◽  
Baoshan Yuan
Keyword(s):  
Breast Cancer ◽  
Therapeutic Intervention ◽  
Intervention Development ◽  
Ph Sensitive ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Viable Approach

Abstract The authors have withdrawn this preprint due to author disagreement.

Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

2019 ◽  
Vol 160 ◽  
pp. 130-142 ◽  
Author(s):  
Vivek Dave ◽  
Kajal Tak ◽  
Amit Sohgaura ◽  
Ashish Gupta ◽  
Veera Sadhu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Nanoparticles Synthesis

Photoresponsive lipid-polymer hybrid nanoparticles for controlled doxorubicin release

2017 ◽  
Vol 28 (25) ◽  
pp. 255101 ◽  
Author(s):  
Cuiping Yao ◽  
Ming Wu ◽  
Cecheng Zhang ◽  
Xinyi Lin ◽  
Zuwu Wei ◽  
...  
Keyword(s):  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Doxorubicin Release

scholarly journals Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system

2017 ◽  
Vol 2 (4) ◽  
pp. 269-280 ◽  
Author(s):  
Vivek Dave ◽  
Renu Bala Yadav ◽  
Kriti Kushwaha ◽  
Sachdev Yadav ◽  
Swapnil Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Statistical Optimization ◽  
Hybrid Nanoparticles ◽  
Topical Drug Delivery ◽  
Polymer Hybrid

Pulmonary delivery of antitubercular drugs using spray-dried lipid–polymer hybrid nanoparticles

2015 ◽  
Vol 44 (6) ◽  
pp. 1544-1555 ◽  
Author(s):  
Ankur Bhardwaj ◽  
Shuchi Mehta ◽  
Shailendra Yadav ◽  
Sudheer K. Singh ◽  
Anne Grobler ◽  
...  
Keyword(s):  
Pulmonary Delivery ◽  
Hybrid Nanoparticles ◽  
Antitubercular Drugs ◽  
Polymer Hybrid ◽  
Spray Dried
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