scholarly journals A Novel Octapeptide Derived From G Protein-Coupled Receptor 124 Improves Cognitive Function Via Pro-Angiogenesis In A Rat Model Of Chronic Cerebral Hypoperfusion-Induced Vascular Dementia

2019 ◽  
Vol Volume 13 ◽  
pp. 3669-3682 ◽  
Author(s):  
Ying Xiao ◽  
Hong Shen ◽  
Rui Li ◽  
Xia Zhou ◽  
Hong Xiao ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Vascular Dementia ◽  
G Protein ◽  
Rat Model ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease

2020 ◽  
Vol 46 (1) ◽  
pp. E44-E55
Author(s):  
Benjamin Galet ◽  
Manuela Ingallinesi ◽  
Jonathan Pegon ◽  
Anh Do Thi ◽  
Philippe Ravassard ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
G Protein ◽  
Rat Model ◽  
Psychiatric Symptoms ◽  
Early Stage ◽  
Male Rat ◽  
G Protein Coupled Receptor ◽  
Motor Disability ◽  
The Impact ◽  
G Protein Coupled

Background: In addition to motor disability, another characteristic feature of Parkinson disease is the early appearance of psychiatric symptoms, including apathy, depression, anxiety and cognitive deficits; treatments for these symptoms are limited by the development of adverse effects such as impulse-control disorders. In this context, we investigated the orphan G protein-coupled receptor 88 (GPR88) as a novel therapeutic target. Methods: We used lentiviral-mediated expression of specifically designed microRNA to knock down Gpr88 in a translational male rat model of early Parkinson disease obtained by dopamine loss in the dorsolateral striatum as a result of 6-hydroxydopamine lesions. We evaluated the impact of Gpr88 knockdown on the Parkinson disease model using behavioural, immunohistochemical and in situ hybridization studies. Results: Knockdown of Gpr88 in associative territories of the dorsal striatum efficiently reduced alterations in mood, motivation and cognition through modulation of the regulator of the G-protein signalling 4 and of the truncated splice variant of the FosB transcription factor. Knockdown of Gpr88 also reduced allostatic changes in striatal activity markers that may be related to patterns observed in patients and that provide support for an “overload” hypothesis for the etiology of the psychiatric symptoms of Parkinson disease. Limitations: Behavioural tests assessing specific cognitive and motivational parameters are needed to further characterize the effects of the lesion and of Gpr88 knockdown in early-stage and advanced Parkinson disease models, presenting more extensive dopamine loss. Additional studies focusing on the direct and indirect striatal output pathways are also required, because little is known about the signalling pathways regulated by GPR88 in different striatal cell types. Conclusion: GPR88 may constitute a highly relevant target for the treatment of the psychiatric symptoms of Parkinson disease.

The effect of intra-striatal administration of GPR55 agonist (LPI) and antagonist (ML193) on sensorimotor and motor functions in a Parkinson’s disease rat model

2020 ◽  
pp. 1-7
Author(s):  
Iman Fatemi ◽  
Abbas Abdollahi ◽  
Ali Shamsizadeh ◽  
Mohammad Allahtavakoli ◽  
Ali Roohbakhsh
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Locomotor Activity ◽  
G Protein ◽  
Rat Model ◽  
Field Tests ◽  
Motor Deficits ◽  
G Protein Coupled Receptor ◽  
Motor Functions ◽  
G Protein Coupled

Abstract Objective: G protein-coupled receptor 55 (GPR55) is an orphan G protein-coupled receptor with various physiological functions. Recent evidence suggests that this receptor may be involved in the control of motor functions. Therefore, in the present study, we evaluated the effects of intra-striatal administration of GPR55 selective ligands in a rat model of Parkinson’s disease. Methods: Experimental Parkinson was induced by unilateral intra-striatal administration of 6-hydroxydopamine (6-OHDA, 10 µg/rat). L-α-lysophosphatidylinositol (LPI, 1 and 5 µg/rat), an endogenous GPR55 agonist, and ML193 (1 and 5 µg/rat), a selective GPR55 antagonist, were injected into the striatum of 6-OHDA-lesioned rats. Motor performance and balance skills were evaluated using the accelerating rotating rod and the ledged beam tests. The sensorimotor function of the forelimbs and locomotor activity were assessed by the adhesive removal and open field tests, respectively. Results: 6-OHDA-lesioned rats had impaired behaviours in all tests. Intra-striatal administration of LPI in 6-OHDA-lesioned rats increased time on the rotarod, decreased latency to remove the label, with no significant effect on slip steps, and locomotor activity. Intra-striatal administration of ML193 also increased time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats mostly at the dose of 1 µg/rat. Conclusions: This study suggests that the striatal GPR55 is involved in the control of motor functions. However, considering the similar effects of GPR55 agonist and antagonist, it may be concluded that this receptor has a modulatory role in the control of motor deficits in an experimental model of Parkinson.

Neurorestorative effects of epigallocatechin-3-Gallate on cognitive function in a chronic cerebral hypoperfusion rat model

2016 ◽  
Vol 34 (3) ◽  
pp. 367-377 ◽  
Author(s):  
Jae-Young Han ◽  
Jung-Kook Kim ◽  
Jae-Hong Kim ◽  
Bong-Seok Oh ◽  
Wan-Ju Cho ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Rat Model ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion

G protein-coupled receptor kinase 6/β-arrestin 2 system in a rat model of dopamine supersensitivity psychosis

2015 ◽  
Vol 29 (12) ◽  
pp. 1308-1313 ◽  
Author(s):  
Yasunori Oda ◽  
Shigenori Tadokoro ◽  
Masayuki Takase ◽  
Nobuhisa Kanahara ◽  
Hiroyuki Watanabe ◽  
...  
Keyword(s):  
G Protein ◽  
Rat Model ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Dopamine Supersensitivity

P.1.h.009 Local inactivation of G protein-coupled receptor 88 restores motor and cognitive functions impaired in a rat model of schizophrenia

2014 ◽  
Vol 24 ◽  
pp. S275
Author(s):  
M. Ingallinesi ◽  
L. Le Bouil ◽  
N. Faucon Biguet ◽  
M.J. Millan ◽  
P. Ravassard ◽  
...  
Keyword(s):  
G Protein ◽  
Rat Model ◽  
Cognitive Functions ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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