scholarly journals The effect of etomidate or propofol on brainstem function during anesthesia induction: a bispectral index-guided study

2019 ◽  
Vol Volume 13 ◽  
pp. 1941-1946
Author(s):  
Huibao Zheng ◽  
Yuexin Zhu ◽  
Kaizheng Chen ◽  
Xia Shen
1999 ◽  
Vol 37 (4) ◽  
pp. 580 ◽  
Author(s):  
Ho Yeong Kil ◽  
Seong Ik Lee ◽  
Yeong Hwan Choi ◽  
Seung Joon Lee ◽  
Young Joo Park ◽  
...  

2006 ◽  
Vol 104 (4) ◽  
pp. 686-695 ◽  
Author(s):  
Ngai Liu ◽  
Thierry Chazot ◽  
Antoine Genty ◽  
Alain Landais ◽  
Aymeric Restoux ◽  
...  

Background This report describes a closed-loop titration of propofol target control infusion based on a proportional-differential algorithm guided by the Bispectral Index (BIS) allowing induction and maintenance of general anesthesia and compares this to manual propofol target control infusion. Methods One hundred sixty-four patients scheduled to undergo elective minor or major surgery were prospectively randomized in a multicenter study into the closed-loop (n = 83) or manual target control infusion group (n = 81). The goal was to reach a BIS target of 50 during induction and to maintain it between 40 and 60 during maintenance. For both groups, remifentanil target control infusion was adjusted manually, and ventilation was without nitrous oxide. Results Closed-loop control was able to provide anesthesia induction and maintenance for all patients. During induction, propofol consumption was lower in the closed-loop group (1.4 +/- 0.5 vs. 1.8 +/- 0.6 mg/kg; P < 0.0001), but the duration was longer (320 +/- 125 vs. 271 +/- 120 s; P < 0.0002). Adequate anesthesia maintenance, defined as the BIS in the range of 40-60, was significantly higher in the closed-loop group (89 +/- 9 vs. 70 +/- 21%; P < 0.0001), with a decrease of the occurrence of BIS less than 40 (8 +/- 8 vs. 26 +/- 22%; P < 0.0001). Time from discontinuation of propofol infusion to tracheal extubation was shorter in the closed-loop group (7 +/- 4 vs. 10 +/- 7 min; P < 0.017). Unwanted somatic events and hemodynamic instability were similar. Conclusion Automatic control of consciousness using the BIS is clinically feasible and outperforms manual control.


2019 ◽  
Vol 69 (4) ◽  
pp. 377-382
Author(s):  
Ana Leitão Ferreira ◽  
Joaquim Gabriel Mendes ◽  
Catarina Sofia Nunes ◽  
Pedro Amorim

2005 ◽  
Vol 49 (5) ◽  
pp. 663 ◽  
Author(s):  
Ji Young Lee ◽  
Se Ho Moon ◽  
Hyun Sik Chung

2002 ◽  
Vol 14 (2) ◽  
pp. 146-149 ◽  
Author(s):  
Masayasu Nakayama ◽  
Hiromichi Ichinose ◽  
Shuji Yamamoto ◽  
Noriaki Kanaya ◽  
Akiyoshi Namiki

2017 ◽  
Vol 47 (11) ◽  
Author(s):  
Mauricio Deschk ◽  
Thomas Alexander Trein ◽  
Juliana Tessália Wagatsuma ◽  
Guilherme Lopes da Silva ◽  
Marcelo Augusto de Araújo ◽  
...  

ABSTRACT: The aim of this study was to evaluate the bispectral index (BIS) effects in calves through continuous infusion of propofol with or without fentanyl. Eight Holstein male calves (ages from six to twelve months old) with an average weight of 123±18kg were used. All animals participated in both groups, always keeping a minimum interval of one week between the anesthetic procedures; the calves were randomly distributed between groups. Anesthesia was induced with an intravenous (IV) dose of propofol of 5mg kg-1 in control group (GP) or with propofol (4mg kg-1) associated with IV fentanyl 0.001mg kg-1(GF). All the calves were positioned in right lateral recumbency and were allowed to spontaneously breathe room air. Subsequently, the anesthesia was maintained by continuous infusion of propofol at the rate of 0.6mg kg-1 min-1 IV in GP, and associated with the infusion of fentanyl 0.001mg kg-1 hour-1 in GF. Measurements of BIS, signal quality index (SQI) and electromyography (EMG) were evaluated before anesthesia induction (TB), and at 15, 30, 45 and 60 minutes after the beginning of continuous drugs infusion (T15, T30, T45 and T60, respectively). The heart rate (HR), respiratory rate (f), end-tidal carbon dioxide tension (ETCO2) and recovery times were evaluated as well. No significant differences were observed between the groups in the BIS variables and the recovery time was longer in GF. Co-administration of propofol and fentanyl infusions, at the doses reported here, did not change the values of BIS in cattle, but delayed the recovery time.


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