scholarly journals Best tigecycline dosing for treatment of infections caused by multidrug-resistant pathogens in critically ill patients with different body weights

2018 ◽  
Vol Volume 12 ◽  
pp. 4171-4179 ◽  
Author(s):  
Mohamed M. Ibrahim ◽  
Abdulla M. Abuelmatty ◽  
Gehan H. Mohamed ◽  
Mohsen A. Nasr ◽  
Amal K. Hussein ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Multidrug Resistant ◽  
Body Weights ◽  
Multidrug Resistant Pathogens

Acquisition of Multidrug-Resistant Organisms Among Hospital Patients Hospitalized in Beds Adjacent to Critically Ill Patients

2006 ◽  
Vol 27 (7) ◽  
pp. 675-681 ◽  
Author(s):  
Matan J. Cohen ◽  
Olga Anshelevich ◽  
David Raveh ◽  
Ellen Broide ◽  
Bernard Rudensky ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Medical Center ◽  
Multidrug Resistant ◽  
Incidence Rates ◽  
Critically Ill Patient ◽  
Do Not Resuscitate ◽  
Increased Risk ◽  
Multidrug Resistant Pathogens

Objective.To assess whether patients hospitalized in beds physically adjacent to critically ill patients are at increased risk to acquire multidrug-resistant pathogens.Design.Cohort study.Setting.Shaare Zedek Medical Center, a 550-bed medical referral center.Patients.From April to September 2004, we enrolled consecutive newly admitted patients who were hospitalized in beds adjacent to either mechanically ventilated patients or patients designated as “do not resuscitate” (DNR). For each of these patients, we also enrolled a control patient who was not hospitalized in a bed adjacent to a critically ill patient. We collected specimens from the anterior nares, the oral cavity, and the perianal zone at the time of admission and subsequently at 3-day intervals until discharge or death. Specimens were cultured on selective media to detect growth of antibiotic-resistant pathogens, includingAcinetobacter baumannii, methicillin-resistantStaphylococcus aureus(MRSA), extended-spectrum β lactamase (ESBL)–producing Enterobacteriaceae, and vancomycin-resistant enterococci (VRE).Results.We enrolled 46 neighbor-control pairs. Among neighbors and controls, respectively, the incidence rates for isolation ofA. baumanniiwas 8.3 and 4 isolations per 100 patient-days (relative risk [RR], 2.1 [95% confidence interval {CI}, 0.8-5.2];P= .12), the incidence rates for MRSA were 1.4 and 2.6 isolations per 100 patient-days (RR, 0.6 [95% CI, 0.1-2.3];P= .45), the incidence rates for ESBL-producing Enterobacteriaceae were 10.5 and 9 isolations per 100 patient-days (RR, 1.2 [95% CI, 0.6-2.4];P= .84), the incidence rates for VRE were 4.3 and 4.8 isolations per 100 patient-days (RR, 0.9 [95% CI, 0.3-2.4];P= 1), and the composite incidence rate was 21.7 and 16.2 isolations per 100 patient-days (RR, 1.3 [95% CI, 0.8-2.3];P= 0.3).Conclusions.In this pilot study, we did not detect an increased incidence rate of isolation of multidrug-resistant pathogens among patients hospitalized in beds adjacent to critically ill patients. Further studies with larger samples should be conducted in order to generate valid data and provide patients, physicians, and policy makers with a sufficient knowledge base from which decisions can be made.

scholarly journals The lower respiratory tract microbiome of critically ill patients with COVID-19

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Paolo Gaibani ◽  
Elisa Viciani ◽  
Michele Bartoletti ◽  
Russell E. Lewis ◽  
Tommaso Tonetti ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Lower Respiratory Tract ◽  
Multidrug Resistant ◽  
Carbapenem Resistant ◽  
Lung Microbiome ◽  
Bacterial Microbiome ◽  
Unweighted Unifrac ◽  
Bacterial Superinfection

AbstractCOVID-19 infection may predispose to secondary bacterial infection which is associated with poor clinical outcome especially among critically ill patients. We aimed to characterize the lower respiratory tract bacterial microbiome of COVID-19 critically ill patients in comparison to COVID-19-negative patients. We performed a 16S rRNA profiling on bronchoalveolar lavage (BAL) samples collected between April and May 2020 from 24 COVID-19 critically ill subjects and 24 patients with non-COVID-19 pneumonia. Lung microbiome of critically ill patients with COVID-19 was characterized by a different bacterial diversity (PERMANOVA on weighted and unweighted UniFrac Pr(> F) = 0.001) compared to COVID-19-negative patients with pneumonia. Pseudomonas alcaligenes, Clostridium hiranonis, Acinetobacter schindleri, Sphingobacterium spp., Acinetobacter spp. and Enterobacteriaceae, characterized lung microbiome of COVID-19 critically ill patients (LDA score > 2), while COVID-19-negative patients showed a higher abundance of lung commensal bacteria (Haemophilus influenzae, Veillonella dispar, Granulicatella spp., Porphyromonas spp., and Streptococcus spp.). The incidence rate (IR) of infections during COVID-19 pandemic showed a significant increase of carbapenem-resistant Acinetobacter baumannii (CR-Ab) infection. In conclusion, SARS-CoV-2 infection and antibiotic pressure may predispose critically ill patients to bacterial superinfection due to opportunistic multidrug resistant pathogens.

scholarly journals Multidrug resistant bacteria in critically ill patients: a step further antibiotic therapy

2018 ◽  
Vol 2 ◽  
pp. 103-103 ◽  
Author(s):  
Martina Tosi ◽  
Erika Roat ◽  
Sara De Biasi ◽  
Elena Munari ◽  
Sophie Venturelli ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria

Antibiotic-Impregnated Catheters Associated With Significant Decrease in Nosocomial and Multidrug-Resistant Bacteremias in Critically Ill Patients

CHEST Journal ◽  
2003 ◽  
Vol 124 (3) ◽  
pp. 1030-1038 ◽  
Author(s):  
Hend A. Hanna ◽  
Issam I. Raad ◽  
Brenda Hackett ◽  
Susannah K. Wallace ◽  
Kristen J. Price ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Multidrug Resistant

46: PREDICTIVE FACTORS FOR MULTIDRUG-RESISTANT PNEUMONIA IN CRITICALLY ILL PATIENTS: THE DEFINE STUDY

2018 ◽  
Vol 46 (1) ◽  
pp. 23-23
Author(s):  
Ishaq Lat ◽  
Mitchell Daley ◽  
Mark Pangrazzi ◽  
Anand Shewale ◽  
Drayton Hammond ◽  
...  
Keyword(s):  
Critically Ill ◽  
Predictive Factors ◽  
Critically Ill Patients ◽  
Multidrug Resistant
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