scholarly journals Baicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca2+-dependent pathway

2018 ◽  
Vol Volume 12 ◽  
pp. 3247-3261 ◽  
Author(s):  
Yihao Zhu ◽  
Jiang Fang ◽  
Handong Wang ◽  
Maoxing Fei ◽  
Ting Tang ◽  
...  
Keyword(s):  
Migration And Invasion ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Dependent Pathway

scholarly journals Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway

2019 ◽  
Vol Volume 13 ◽  
pp. 1023-1032 ◽  
Author(s):  
Jingren Shi ◽  
Wenli Zhang ◽  
Lu He ◽  
Fanhong Kong ◽  
Meichen Pan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Migration And Invasion ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

scholarly journals Proliferative and Invasive Effects of Progesterone-Induced Blocking Factor in Human Glioblastoma Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Araceli Gutiérrez-Rodríguez ◽  
Valeria Hansberg-Pastor ◽  
Ignacio Camacho-Arroyo
Keyword(s):  
Migration And Invasion ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Astrocytoma Cells ◽  
Blocking Factor ◽  
Human Glioblastoma Cells ◽  
U87 Cells ◽  
Antagonist Ru486 ◽  
Human Astrocytoma Cells ◽  
Invasion Assays

Progesterone-induced blocking factor (PIBF) is a progesterone (P4) regulated protein expressed in different types of high proliferative cells including astrocytomas, the most frequent and aggressive brain tumors. It has been shown that PIBF increases the number of human astrocytoma cells. In this work, we evaluated PIBF regulation by P4 and the effects of PIBF on proliferation, migration, and invasion of U87 and U251 cells, both derived from human glioblastomas. PIBF mRNA expression was upregulated by P4 (10 nM) from 12 to 24 h. Glioblastoma cells expressed two PIBF isoforms, 90 and 57 kDa. The content of the shorter isoform was increased by P4 at 24 h, while progesterone receptor antagonist RU486 (10 μM) blocked this effect. PIBF (100 ng/mL) increased the number of U87 cells on days 4 and 5 of treatment and induced cell proliferation on day 4. Wound-healing assays showed that PIBF increased the migration of U87 (12–48 h) and U251 (24 and 48 h) cells. Transwell invasion assays showed that PIBF augmented the number of invasive cells in both cell lines at 24 h. These data suggest that PIBF promotes proliferation, migration, and invasion of human glioblastoma cells.

scholarly journals Reduction of protein kinase C ζ inhibits migration and invasion of human glioblastoma cells

2009 ◽  
Vol 109 (1) ◽  
pp. 203-213 ◽  
Author(s):  
Hua Guo ◽  
Feng Gu ◽  
Wenliang Li ◽  
Baogang Zhang ◽  
Ruifang Niu ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Migration And Invasion ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Kinase C ◽  
Human Glioblastoma Cells

The interplay between intracellular progesterone receptor and PKC plays a key role in migration and invasion of human glioblastoma cells

2017 ◽  
Vol 172 ◽  
pp. 198-206 ◽  
Author(s):  
Brenda Marquina-Sánchez ◽  
Jesús González-Jorge ◽  
Valeria Hansberg-Pastor ◽  
Talia Wegman-Ostrosky ◽  
Noemi Baranda-Ávila ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Migration And Invasion ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells
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