scholarly journals A comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects

2017 ◽  
Vol Volume 11 ◽  
pp. 3171-3177 ◽  
Author(s):  
Yu Kyong Kim ◽  
Mun Ju Choi ◽  
Tae Young Oh ◽  
Kyung-Sang Yu ◽  
SeungHwan Lee
Keyword(s):  
Fumaric Acid ◽  
Healthy Subjects ◽  
Orotic Acid ◽  
The Novel ◽  
Acid Salt ◽  
Salt Form ◽  
Comparative Pharmacokinetic

scholarly journals Importance of between and within Subject Variability in Extracellular Vesicle Abundance and Cargo when Performing Biomarker Analyses

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 485
Author(s):  
Lauren A. Newman ◽  
Alia Fahmy ◽  
Michael J. Sorich ◽  
Oliver G. Best ◽  
Andrew Rowland ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Drug Exposure ◽  
Extracellular Vesicle ◽  
The Novel ◽  
Protein Markers ◽  
Diurnal Variability ◽  
Normal Ranges ◽  
Sampling Protocols ◽  
Subject Variability ◽  
Within Subject Variability

Small extracellular vesicles (sEV) have emerged as a potential rich source of biomarkers in human blood and present the intriguing potential for a ‘liquid biopsy’ to track disease and the effectiveness of interventions. Recently, we have further demonstrated the potential for EV derived biomarkers to account for variability in drug exposure. This study sought to evaluate the variability in abundance and cargo of global and liver-specific circulating sEV, within (diurnal) and between individuals in a cohort of healthy subjects (n = 10). We present normal ranges for EV concentration and size and expression of generic EV protein markers and the liver-specific asialoglycoprotein receptor 1 (ASGR1) in samples collected in the morning and afternoon. EV abundance and cargo was generally not affected by fasting, except CD9 which exhibited a statistically significant increase (p = 0.018). Diurnal variability was observed in the expression of CD81 and ASGR1, which significantly decreased (p = 0.011) and increased (p = 0.009), respectively. These results have potential implications for study sampling protocols and normalisation of biomarker data when considering the expression of sEV derived cargo as a biomarker strategy. Specifically, the novel finding that liver-specific EVs exhibit diurnal variability in healthy subjects should have broad implications in the study of drug metabolism and development of minimally invasive biomarkers for liver disease.

P3-283: Pharmacokinetics, pharmacodynamics, and safety of the novel bace inhibitor bi1181181 after oral administration of single ascending doses in healthy subjects

2015 ◽  
Vol 11 (7S_Part_16) ◽  
pp. P740-P741 ◽  
Author(s):  
Laurent Nicolas ◽  
Klaus-Peter Kammerer ◽  
Jennifer Schaible ◽  
Jasmin Link ◽  
Oliver Kleiner ◽  
...  
Keyword(s):  
Oral Administration ◽  
Healthy Subjects ◽  
The Novel ◽  
Bace Inhibitor

scholarly journals Functions of a Chitosan-Orotic Acid Salt in the Gastrointestinal Tract

2003 ◽  
Vol 26 (5) ◽  
pp. 687-690 ◽  
Author(s):  
Yoshifumi Murata ◽  
Naoko Kojima ◽  
Susumu Kawashima
Keyword(s):  
Gastrointestinal Tract ◽  
Orotic Acid ◽  
Acid Salt

scholarly journals Peptimetric: Quantifying and visualizing differences in peptidomic data

2021 ◽  
Author(s):  
Erik Hartman ◽  
Simon Mahdavi ◽  
Sven Kjellstrom ◽  
Artur Schmidtchen
Keyword(s):  
Mass Spectrometry ◽  
Web Application ◽  
Healthy Subjects ◽  
Rapid Development ◽  
Protein Quantification ◽  
Diabetic Patients ◽  
The Novel ◽  
Single Experiment ◽  
Endogenous Peptides ◽  
Multiple Samples

Finding new sustainable means of diagnosing and treating diseases is one of the most pressing issues of our time. In recent years, several endogenous peptides have been found to be both excellent biomarkers for many diseases and to possess important physiological roles which may be utilized in treatments. The detection of peptides has been facilitated by the rapid development of biological mass spectrometry and now the combination of fast and sensitive high resolution MS instruments and stable nano HP-LC equipment sequences thousands of peptides in one single experiment. In most research conducted with these advanced systems, proteolytically cleaved proteins are analyzed and the specific peptides are identified by software dedicated for protein quantification using different proteomics workflows. Analysis of endogenous peptides with peptidomics workflows also benefit from the novel sensitive and advanced instrumentation, however, the generated peptidomic data is vast and subsequently laborious to visualize and examine, creating a bottleneck in the analysis. Therefore, we have created Peptimetric, an application designed to allow researchers to investigate and discover differences between peptidomic samples. Peptimetric allows the user to dynamically and interactively investigate the proteins, peptides, and some general characteristics of multiple samples, and is available as a web application at \url{https://peptimetric.herokuapp.com}. To illustrate the utility of Peptimetric, we've applied it to a peptidomic dataset of 15 urine samples from diabetic patients and corresponding data from healthy subjects.

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