scholarly journals Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D

2016 ◽  
Vol Volume 10 ◽  
pp. 2049-2060 ◽  
Author(s):  
Zhongcheng Ke ◽  
Xuefeng Hou ◽  
Xiao-bin Jia
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Design And Optimization

Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia

2021 ◽  
Vol 61 ◽  
pp. 102241
Author(s):  
Kantaporn Kheawfu ◽  
Surachai Pikulkaew ◽  
Thomas Rades ◽  
Anette Müllertz ◽  
Louise von Gersdorff Jørgensen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Clove Oil ◽  
Design And Optimization

scholarly journals Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

2012 ◽  
Vol 431 (1-2) ◽  
pp. 161-175 ◽  
Author(s):  
Ana Maria Sierra Villar ◽  
Beatriz Clares Naveros ◽  
Ana Cristina Calpena Campmany ◽  
Monserrat Aróztegui Trenchs ◽  
Coloma Barbé Rocabert ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Design And Optimization ◽  
Enhanced Dissolution

Design and optimization of MEMS based piezoelectric actuator for drug delivery systems

2019 ◽  
Vol 26 (5) ◽  
pp. 1671-1679 ◽  
Author(s):  
K. Srinivasa Rao ◽  
Md. Hamza ◽  
P. Ashok Kumar ◽  
K. Girija Sravani
Keyword(s):  
Drug Delivery ◽  
Piezoelectric Actuator ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Design And Optimization

scholarly journals Design and Optimization of the Circulatory Cell-Driven Drug Delivery Platform

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Pengyu Gao ◽  
Dan Zou ◽  
Ansha Zhao ◽  
Ping Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Cell Function ◽  
Survival Rates ◽  
Circulatory System ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Design And Optimization ◽  
Targeting Efficiency ◽  
Blood Circulatory System

Achievement of high targeting efficiency for a drug delivery system remains a challenge of tumor diagnoses and nonsurgery therapies. Although nanoparticle-based drug delivery systems have made great progress in extending circulation time, improving durability, and controlling drug release, the targeting efficiency remains low. And the development is limited to reducing side effects since overall survival rates are mostly unchanged. Therefore, great efforts have been made to explore cell-driven drug delivery systems in the tumor area. Cells, particularly those in the blood circulatory system, meet most of the demands that the nanoparticle-based delivery systems do not. These cells possess extended circulation times and innate chemomigration ability and can activate an immune response that exerts therapeutic effects. However, new challenges have emerged, such as payloads, cell function change, cargo leakage, and in situ release. Generally, employing cells from the blood circulatory system as cargo carriers has achieved great benefits and paved the way for tumor diagnosis and therapy. This review specifically covers (a) the properties of red blood cells, monocytes, macrophages, neutrophils, natural killer cells, T lymphocytes, and mesenchymal stem cells; (b) the loading strategies to balance cargo amounts and cell function balance; (c) the cascade strategies to improve cell-driven targeting delivery efficiency; and (d) the features and applications of cell membranes, artificial cells, and extracellular vesicles in cancer treatment.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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