scholarly journals Rupatadine Oral Solution Titration by Body Weight in Paediatric Patients Suffering from Allergic Rhinitis: A Population Pharmacokinetic Study

2021 ◽  
Vol Volume 13 ◽  
pp. 115-122
Author(s):  
Eva Santamaria ◽  
Iñaki Izquierdo ◽  
Marta Valle
Keyword(s):  
Allergic Rhinitis ◽  
Body Weight ◽  
Pharmacokinetic Study ◽  
Oral Solution ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Study ◽  
Paediatric Patients

scholarly journals Dosing Recommendations for Vancomycin in Children and Adolescents with Varying Levels of Obesity and Renal Dysfunction: a Population Pharmacokinetic Study in 1892 Children Aged 1–18 Years

2021 ◽  
Vol 23 (3) ◽  
Author(s):  
Cornelis Smit ◽  
Sebastiaan C. Goulooze ◽  
Roger J. M. Brüggemann ◽  
Catherine M. Sherwin ◽  
Catherijne A. J. Knibbe
Keyword(s):  
Renal Function ◽  
Body Weight ◽  
Children And Adolescents ◽  
Pharmacokinetic Study ◽  
Pediatric Population ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Data ◽  
Obese Children ◽  
Population Pharmacokinetic Study

AbstractVancomycin is an effective but potentially nephrotoxic antibiotic commonly used for severe infections. Dosing guidelines for vancomycin in obese children and adolescents with or without renal impairment are currently lacking. This study describes the pharmacokinetics of vancomycin in a large pediatric cohort with varying degrees of obesity and renal function to design practical dosing guidelines for this population. A multi-center retrospective population pharmacokinetic study was conducted using data from patients aged 1−18 years who received >1 dose of vancomycin and had ≥1 vancomycin concentration measured between January 2006 and December 2012. Besides pharmacokinetic data, age, gender, body weight, creatinine clearance (CLcr, bedside Schwartz equation), ward, race, and neutropenic status were collected. Population pharmacokinetic analysis and simulations were performed using NONMEM7.4. A total of 1892 patients (5524 samples) were included, with total body weight (TBW) ranging 6−188 kg (1344 normal weight, 247 overweight, and 301 obese patients) and CLcr down to 8.6 mL/min/1.73 m2. The two-compartment model, with clearance (CL) significantly increasing with TBW and CLcr, central and peripheral volume of distribution and inter-compartmental clearance increasing with TBW, performed well for all age, weight, and renal function ranges. A dosing guideline is proposed that integrates body weight and CLcr resulting in effective and safe exposures across all ages, body weight, and renal functions in the pediatric population. We have characterized the full pharmacokinetic profile of vancomycin in obese children and adolescents aged 1−18 years and propose a practical dosing guideline that integrates both body weight and renal function.

scholarly journals Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study

Critical Care ◽  
2018 ◽  
Vol 22 (1) ◽  
Author(s):  
Stephan Braune ◽  
Christina König ◽  
Jason A. Roberts ◽  
Axel Nierhaus ◽  
Oliver Steinmetz ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Study ◽  
Low Efficiency
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