scholarly journals Comparative analysis of the safety and tolerability of fixed-dose artesunate/amodiaquine versus artemether/lumefantrine combinations for uncomplicated falciparum malaria in pregnancy: a randomized open label study

2017 ◽  
Vol Volume 9 ◽  
pp. 45-54
Author(s):  
Osede Iribhogbe ◽  
Igue Emmanuel ◽  
Marylove Odianosen
Keyword(s):  
Comparative Analysis ◽  
Malaria In Pregnancy ◽  
Fixed Dose ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
In Pregnancy

scholarly journals A 6-month, multicenter, open-label study of fixed dose naproxen/esomeprazole in adolescent patients with juvenile idiopathic arthritis

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Daniel J. Lovell ◽  
Jason A. Dare ◽  
Megan Francis-Sedlak ◽  
Julie Ball ◽  
Brian D. LaMoreaux ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Fixed Dose ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Adolescent Patients

Mirtazapine treatment of Generalized Anxiety Disorder: a fixed dose, open label study

2005 ◽  
Vol 19 (5) ◽  
pp. 483-487 ◽  
Author(s):  
Francesco Gambi ◽  
Domenico De Berardis ◽  
Daniela Campanella ◽  
Alessandro Carano ◽  
Gianna Sepede ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Fixed Dose ◽  
Generalized Anxiety ◽  
Open Label ◽  
Open Label Study ◽  
Label Study

Fixed-dose gabapentin augmentation in the treatment of alcohol withdrawal syndrome: a retrospective, open-label study

2019 ◽  
Vol 46 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Alex Andaluz ◽  
Dustin DeMoss ◽  
Cynthia Claassen ◽  
Somer Blair ◽  
Jennifer Hsu ◽  
...  
Keyword(s):  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Alcohol Withdrawal Syndrome ◽  
Fixed Dose ◽  
Open Label ◽  
Open Label Study ◽  
Label Study

scholarly journals A prospective and open label study of use of cilnidipine and chlorthalidone fixed dose combination in Indian hypertensive patients, intolerant or uncontrolled on amlodipine and hydrochlorothiazide combination

2017 ◽  
Vol 4 (6) ◽  
pp. 1522
Author(s):  
Suresh V. Sagarad ◽  
Hari Prasad S.
Keyword(s):  
Blood Pressure ◽  
Antihypertensive Efficacy ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Hypertensive Patients ◽  
Blood Pressures ◽  
Dose Combination

Background:Primary aim of this study was to evaluate the antihypertensive efficacy of the Cilnidipine and Chlorthalidone fixed dose combination in Indian hypertensive patients who are not controlled on traditionally used amlodipine and hydrochlorothiazide combination and also to evaluate the safety of this combination.Methods: A total of 70 eligible patients were enrolled in this prospective, open label study. The patients were given cilnidipine (10 mg) and chlorthalidone (12.5 mg) who had not achieved target blood pressure (140/90 mmHg) despite on amlodipine (5 mg) and hydrochlorothiazide (12.5mg) combination or are intolerant to the medication. The assessment was done at the end of 4 weeks and 8 weeks.Results: There were significant falls in the SBP (5.43±2.45 mmHg, P<0.05), and DBP (4.11±2.35 mmHg, P<0.05) at the end of 4 weeks as compared to those at the baseline. The trend was sustained at 8 weeks. No further significant fall in the SBP and DBP were noted after 4 weeks (5.43±2.45 and 5.22±2.38 mmHg at 4 weeks vs 4.11±2.35 and 4.01±2.23 mmHg at 8 weeks P=NS). The SBP target (140 mmHg) was achieved in 25 patients (35.71%). The DBP target (90 mmHg) was achieved in 18 patients (25.71%). The combined SBP and DBP target was achieved in 12 patients (17.14%). A similar fall in the SBP was observed in the subgroups which were analysed.Conclusions: The hypertensive patients who do not achieve the target blood pressures on amlodipine and hydrochlorothiazide can be switched to the cilnidipine and chlorthalidone combination. The combination is effective and well tolerated.

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