scholarly journals Potential role of stem cells in management of COPD

2010 ◽  
pp. 81
Author(s):  
Don Sin
Keyword(s):  
Stem Cells ◽  
Potential Role

Stem Cells from Human Exfoliated Deciduous Teeth and their Promise as Preventive and Therapeutic Strategies for Neurological Diseases and Injuries

2021 ◽  
Vol 17 ◽  
Author(s):  
Lingyi Huang ◽  
Zizhuo Zheng ◽  
Ding Bai ◽  
Xianglong Han
Keyword(s):  
Stem Cells ◽  
Potential Role ◽  
Neurological Diseases ◽  
Therapeutic Strategies ◽  
Deciduous Teeth ◽  
Research Attention ◽  
Considerable Potential ◽  
Prevention And Treatment ◽  
Human Exfoliated Deciduous Teeth

Abstract: Stem cells from human exfoliated deciduous teeth (SHEDs) are relatively easy to isolate from exfoliated deciduous teeth, which are obtained via dental therapy as biological waste. SHEDs originate from the embryonic neural crest and therefore have considerable potential for neurogenic differentiation. Currently, an increasing amount of research attention is focused on the therapeutic applications of SHEDs in neurological diseases and injuries. In this article, we summarize the biological characteristics of SHEDs and the potential role of SHEDs and their derivatives, including conditioned medium from SHEDs and the exosomes they secrete, in the prevention and treatment of neurological diseases and injuries.

scholarly journals Potential Role of the Resident Mesenchymal Stem-Like Cells in Renal Fibrogenesis after Ureteral Obstruction

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Yong-Hua Peng ◽  
Jie Xiao ◽  
Chen Yan ◽  
Lan Luo ◽  
Tao-Sheng Li
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ureteral Obstruction ◽  
Potential Role ◽  
Histological Analysis ◽  
Left Kidney ◽  
Inflammatory Cells ◽  
Unilateral Ureteral Obstruction ◽  
Renal Fibrogenesis

The mechanisms of renal fibrogenesis after ureteral obstruction remain unclear. We tried to primarily expand mesenchymal stem cells from renal tissues and then investigated their role in fibrogenesis after ureteral obstruction. Unilateral ureteral obstruction was induced by ligating the left ureteral duct of adult C57BL/6 mice. We collected the kidneys for experiments at 2, 7, and 14 days after operation. Histological analysis showed obviously fibrotic changes in the left kidney at 7 days and further increased at 14 days after ureteral obstruction. To expand mesenchymal stem cells, we minced the renal tissues into small explants (about 1 mm3) and cultured onto 10 cm dishes. Interestingly, the outgrowth of cells was observed significantly earlier from the explants of the obstructed left kidney than that of the unobstructed right kidney. These expanded cells showed the potency of adipogenic, osteogenic, and chondrogenic differentiations and positively expressed with CD44 and partly expressed with CD90, CD105, and CD106, but negatively expressed with CD34, CD45, and FSP1, suggesting the phenotype of mesenchymal stem-like cells (MSLCs). The mouse fibrosis RT2 profiler PCR array showed that many genes were changed over 2-fold in the MSLCs expanded from both kidneys at 2, 7, and 14 days after operation. Interestingly, profibrotic genes were prevalently enhanced in the left kidney with ureteral obstruction. Histological analysis also showed obviously infiltration of inflammatory cells in the left kidney at 14 days after operation. Our data indicate the potential role of resident MSLCs in renal fibrogenesis after ureteral obstruction, but further experiments are required to understand the relevant mechanisms.

The potential role of stem cells in the pathogenesis of endometriosis

2017 ◽  
Vol 23 (2) ◽  
pp. 66
Author(s):  
S. O. Dubrovina ◽  
Yu. D. Berlim ◽  
V. S. Gimbut ◽  
L. V. Krasilnikova ◽  
K. A. Arechan
Keyword(s):  
Stem Cells ◽  
Potential Role

scholarly journals Potential Role of GST-π in Lung Cancer Stem Cell Cisplatin Resistance

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Wenjun Wang ◽  
Jianping Wei ◽  
Xiaoyun Tu ◽  
Xiaoqun Ye
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Protein Expression ◽  
A549 Cell ◽  
Potential Role ◽  
Redox Balance ◽  
Adherent Cells ◽  
Cellular Redox ◽  
Intracellular Ros

Background. Cancer stem cells (CSCs) are responsible for tumorigenesis, chemoresistance, and metastasis. Chemoresistance is a major challenge in the management of lung cancer. Glutathione-sulphur-transferase-π (GST-π) plays an important role in the origin and development of various types of cancer by regulating the cellular redox balance. Recent investigations have demonstrated that GST-π is associated with the chemoresistance of lung CSCs (LCSCs). However, the mechanism of GST-π in lung cancer, particularly in LCSCs, remains unclear. The present study is aimed at exploring the potential role of GST-π in stemness and cisplatin (DDP) resistance of LCSCs. Materials and methods. In the present study, lung cancer cell spheres were established using the A549 cell line, which according to our previous research, was confirmed to exhibit characteristics of stem cells. Next, GST-π protein expression, apoptosis percentage, and intracellular reactive oxygen species (ROS) concentration in A549 adherent cells and A549 cell spheres were analyzed by western blotting and flow cytometry, respectively. Finally, DDP resistance, ROS concentration, and GST-π expression in LCSCs were analyzed following the interference with GST-π using DL-buthionine-(S,R)-sulphoximine and N-acetylcysteine. Results. The results revealed that GST-π was highly expressed in A549 cell spheres compared with A549 adherent cells and was associated with a decreased intracellular ROS concentration (both P < 0.05 ). Regulating GST-π protein expression could alter DDP resistance of LCSCs by influencing ROS. Conclusion. These results suggested that GST-π may be important for LCSC drug resistance by downregulating ROS levels. These findings may contribute to the development of new adjuvant therapeutic strategies for lung cancer.

Chemotherapy resistance in pancreatic cancer – potential role of cancer stem cells

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
A Renner ◽  
Y Zhao ◽  
I Ischenko ◽  
P Camaj ◽  
JW Ellwart ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Potential Role ◽  
Chemotherapy Resistance
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