scholarly journals COPD Exacerbation History and Impact on Future Exacerbations – 8-Year Retrospective Observational Database Cohort Study from Germany

2021 ◽  
Vol Volume 16 ◽  
pp. 2407-2417
Author(s):  
Claus F Vogelmeier ◽  
Joanna Diesing ◽  
Nils Kossack ◽  
Marc Pignot ◽  
Felix W Friedrich
Keyword(s):  
Cohort Study ◽  
Copd Exacerbation ◽  
Observational Database

scholarly journals HLA-B*57:01 screening and hypersensitivity reaction to abacavir between 1999 and 2016 in the OPERA® observational database: a cohort study

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Karam Mounzer ◽  
Ricky Hsu ◽  
Jennifer S. Fusco ◽  
Laurence Brunet ◽  
Cassidy E. Henegar ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hypersensitivity Reaction ◽  
Observational Database

scholarly journals Pre-Hospital Low ALT Activity, a Marker of Sarcopenia and Frailty, is Associated with Increased Long-Term Mortality after COPD Exacerbations. Historic Prospective Cohort Study.

2020 ◽  
Author(s):  
Nir Lasman ◽  
Matan Shalom ◽  
Natia Turpashvili ◽  
Gal Goldhaber ◽  
Yulia Lifshitz ◽  
...  
Keyword(s):  
Cohort Study ◽  
Median Survival ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Copd Exacerbation ◽  
Term Survival ◽  
Long Term Survival ◽  
Copd Exacerbations ◽  
Long Term Mortality

Abstract Background. COPD exacerbations have negative impact on patients' survival. Several risk factors for grave outcomes of such exacerbations have been descried. Muscle dysfunction and mass loss were shown to impact negatively on prognosis and survival. Low activity of the enzyme ALT (Alanine amino-transferase) in the blood is a known indicator for sarcopenia and frailty, however, no previous studies addressed the association of low ALT amongst patients hospitalized due to COPD exacerbation and long-term survival. Methods. This is a historic prospective cohort study of patients hospitalized due to acute COPD exacerbation. Results. Included were 232 consecutive COPD exacerbation patients. The median time of follow-up was 34.9 months (IQR 23.13 – 41.73 months). During this period 104 (44.8%) patients died. All patients were grouped to quartiles according to blood ALT levels (after exclusion of cases considered to have hepatitis (ALT > 40 IU)). The risk of long-term mortality increased, in a statistically significant manner, amongst patients with low ALT values: the median survival of patients with ALT < 11 IU was 18.5 months only while the median survival for the rest of the study group was not reached. For ALT < 11IU; 12-16IU; 17-20IU and >21IU the mortality rates were 69%; 40.9%; 36.3% and 25% respectively (p < 0.001 for comparison of lower quartile with upper three quartiles). The crude hazard ratio for mortality amongst patients with ALT levels lower than 11IU was 2.37 (95% CI; 1.6 – 3.5). This increased risk of mortality remained significant after adjustment for age, weight, creatinine, albumin concentration and cardiovascular diseases (HR = 1.83; 95% CI 1.08 – 3.1, p < 0.05). Conclusions. Low ALT values, a biomarker of sarcopenia and frailty, are associated with poor long-term survival amongst patients hospitalized due to COPD exacerbation.

scholarly journals Effectiveness of empirical anti-pseudomonal antibiotics for recurrent COPD exacerbation: a multicenter retrospective cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akihiro Shiroshita ◽  
Chisato Miyakoshi ◽  
Shunta Tsutsumi ◽  
Hiroshi Shiba ◽  
Chigusa Shirakawa ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hospital Stay ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fixed Effects ◽  
Estimating Equation ◽  
Chronic Obstructive ◽  
Systemic Steroid ◽  
Copd Exacerbation ◽  
Copd Exacerbations

AbstractAlthough frequent chronic obstructive pulmonary disease (COPD) exacerbation has been associated with the isolation of Pseudomonas aeruginosa (PA) in sputum cultures, it remains unknown whether the empirical use of anti-pseudomonal antibiotics can improve outcomes in patients with frequent COPD exacerbations. This multicenter retrospective cohort study evaluated whether the empirical use of anti-pseudomonal antibiotics improves the length of the hospital stay in patients with recurrent COPD exacerbation (≥ 2 admissions from April 1, 2008 to July 31, 2020). For statistical analysis, a log-linked Gamma model was used. Parameters were estimated using a generalized estimating equation model with an exchangeable correlation structure accounting for repeated observations from a single patient. Covariates included age, body mass index, home oxygen therapy use, respiratory rate, heart rate, oxygen use on admission, mental status, systemic steroid use, activities of daily living, and the number of recurrences. Hospital-specific effects were specified as fixed effects. In total, 344 patients and 965 observations of recurrent COPD exacerbations were selected. Anti-pseudomonal antibiotics were used in 173 patients (18%). The estimated change in the length of the hospital stay between anti-pseudomonal and non-anti-pseudomonal antibiotics groups was 0.039 days [95% confidence interval; − 0.083, 0.162]. Anti-pseudomonal antibiotics could not shorten the length of the hospital stay.

Biomarkers as a Prognostic Factor in COPD Exacerbation: A Cohort Study

2021 ◽  
pp. 1-14
Author(s):  
Jaime A. Gómez-Rosero ◽  
Camilo Cáceres-Galvis ◽  
Johana Ascuntar ◽  
Carlos Atencia ◽  
Carlos E. Vallejo ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prognostic Factor ◽  
Copd Exacerbation

scholarly journals Baseline Low ALT Activity, a Marker of Sarcopenia and Frailty, is Associated with Increased Long-Term Mortality after COPD Exacerbations. Historic Prospective Cohort Study.

2020 ◽  
Author(s):  
Nir Lasman ◽  
Matan Shalom ◽  
Natia Turpashvili ◽  
Gal Goldhaber ◽  
Yulia Lifshitz ◽  
...  
Keyword(s):  
Cohort Study ◽  
Median Survival ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Copd Exacerbation ◽  
Term Survival ◽  
Long Term Survival ◽  
Copd Exacerbations ◽  
Long Term Mortality

Abstract Background. COPD exacerbations have negative impact on patients' survival. Several risk factors for grave outcomes of such exacerbations have been descried. Muscle dysfunction and mass loss were shown to impact negatively on prognosis and survival. Low activity of the enzyme ALT (Alanine amino-transferase) in the blood is a known indicator for sarcopenia and frailty, however, no previous studies addressed the association of low ALT amongst patients hospitalized due to COPD exacerbation and long-term survival. Methods. This is a historic prospective cohort study of patients hospitalized due to acute COPD exacerbation. Results. Included were 232 consecutive COPD exacerbation patients. The median time of follow-up was 34.9 months (IQR 23.13 – 41.73 months). During this period 104 (44.8%) patients died. All patients were grouped to quartiles according to blood ALT levels (after exclusion of cases considered to have hepatic tissue damage (ALT > 40 IU)). The risk of long-term mortality increased, in a statistically significant manner, amongst patients with low ALT values: the median survival of patients with ALT < 11 IU was 18.5 months only while the median survival for the rest of the study group was not reached. For ALT < 11IU; 12-16IU; 17-20IU and >21IU the mortality rates were 69%; 40.9%; 36.3% and 25% respectively (p < 0.001 for comparison of lower quartile with upper three quartiles). The crude hazard ratio for mortality amongst patients with ALT levels lower than 11IU was 2.37 (95% CI; 1.6 – 3.5). This increased risk of mortality remained significant after adjustment for age, weight, creatinine, albumin concentration and cardiovascular diseases (HR = 1.83; 95% CI 1.08 – 3.1, p < 0.05). Conclusions. Low ALT values, a biomarker of sarcopenia and frailty, are associated with poor long-term survival amongst patients hospitalized due to COPD exacerbation.

scholarly journals Effectiveness of Empirical Anti-pseudomonal Antibiotics Recurrent COPD Exacerbation: a Multicenter Retrospective Cohort Study

2021 ◽  
Author(s):  
Akihiro Shiroshita ◽  
Chisato Miyakoshi ◽  
Shunta Tsutsumi ◽  
Hiroshi Shiba ◽  
Chigusa Shirakawa ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hospital Stay ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fixed Effects ◽  
Estimating Equation ◽  
Chronic Obstructive ◽  
Systemic Steroid ◽  
Copd Exacerbation ◽  
Copd Exacerbations

Abstract Although frequent chronic obstructive pulmonary disease (COPD) exacerbation has been associated with the isolation of Pseudomonas aeruginosa (PA) in sputum cultures, it remains unknown whether the empirical use of anti-pseudomonal antibiotics can improve outcomes in patients with frequent COPD exacerbations. This multicenter retrospective cohort study evaluated whether the empirical use of anti-pseudomonal antibiotics improves the hospital stay length in patients with recurrent COPD exacerbation (>2 admissions from April 1, 2008 to July 31, 2020). For statistical analysis, a log-linked Gamma model was used. Parameters were estimated using a generalized estimating equation model with an exchangeable correlation structure accounting for repeated observations from a single patient. Covariates included age, body mass index, home oxygen therapy use, respiratory rate, heart rate, oxygen use on admission, mental status, systemic steroid use, activities of daily living, and number of recurrences. Hospital-specific effects were specified as fixed effects. In total, 344 patients and 965 observations of recurrent COPD exacerbations were selected. Anti-pseudomonal antibiotics were used in 173 patients (18%). The estimated change in hospital stay length between anti-pseudomonal and non-anti-pseudomonal antibiotics groups was 0.044 days [95% confidence interval; -0.077, 0.166]. Thus, the use of empirical anti-pseudomonal antibiotics based only on recurrence may not be necessary.

scholarly journals Predictors of 30- and 90-Day COPD Exacerbation Readmission: A Prospective Cohort Study

2021 ◽  
Vol Volume 16 ◽  
pp. 2769-2781
Author(s):  
Jaber S Alqahtani ◽  
Yousef S Aldabayan ◽  
Abdulelah M Aldhahir ◽  
Ahmad M Al Rajeh ◽  
Swapna Mandal ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Copd Exacerbation
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