scholarly journals Associations of Medication Regimen Complexity with COPD Medication Adherence and Control

2021 ◽  
Vol Volume 16 ◽  
pp. 2385-2392
Author(s):  
Alex D Federman ◽  
Rachel O'Conor ◽  
Michael S Wolf ◽  
Juan P Wisnivesky
Keyword(s):  
Medication Adherence ◽  
Medication Regimen ◽  
Medication Regimen Complexity ◽  
Regimen Complexity ◽  
And Control

scholarly journals Medication regimen complexity and medication adherence in elderly patients with chronic kidney disease

2019 ◽  
Vol 23 (3) ◽  
pp. 333-342 ◽  
Author(s):  
Krystina Parker ◽  
Ingrid Bull-Engelstad ◽  
Willy Aasebø ◽  
Nanna von der Lippe ◽  
Morten Reier-Nilsen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Medication Adherence ◽  
Kidney Disease ◽  
Elderly Patients ◽  
Medication Regimen ◽  
Medication Regimen Complexity ◽  
Regimen Complexity

Medication Regimen Complexity and Medication Adherence In Patients with Polypharmacy

2021 ◽  
Vol 11 (2) ◽  
pp. 130-135
Author(s):  
Ms.K.Gnana Swarupini ◽  
Dr.G.RamyaBala Prabha ◽  
Ms.Dharmapuram Santhosha ◽  
Ms. Nadimidoddi Hepciba
Keyword(s):  
Medication Adherence ◽  
Medication Regimen ◽  
Medication Regimen Complexity ◽  
Regimen Complexity

Medication Regimen Complexity and Low Adherence in Older Community-Dwelling Adults With Substantiated Self-Neglect

2017 ◽  
Vol 38 (6) ◽  
pp. 866-883 ◽  
Author(s):  
Sharon Abada ◽  
Leslie E. Clark ◽  
Arup K. Sinha ◽  
Rui Xia ◽  
Kathleen Pace-Murphy ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Linear Regression Analysis ◽  
Community Dwelling ◽  
Medication Regimen ◽  
Protective Services ◽  
Cross Sectional ◽  
Adult Protective Services ◽  
Medication Regimen Complexity ◽  
Regimen Complexity ◽  
Multivariable Linear Regression Analysis

Objective: Determine whether medication regimen complexity predicts medication adherence levels in a sample of community-dwelling adults 65 years and older with Adult Protective Services–substantiated self-neglect. Methods: A cross-sectional analysis of baseline data ( N = 31 participants) from a pilot intervention to increase medication adherence among the target group was performed. The Medication Regimen Complexity Index (MRCI) and the 8-item Morisky Medication Adherence Scale (MMAS-8)™ were the primary independent and dependent measures, respectively. A multivariable linear regression analysis, adjusting for potential confounders, was conducted to estimate the association between complexity and adherence. Results: Regimen complexity was high (mean MRCI = 19.6) and adherence was low (mean MMAS = 5.1). Even after controlling for confounders, increased complexity was significantly associated with lower adherence. Discussion: Older community-dwelling adults who self-neglect have complex medication regimens that contribute to low medication adherence. Medication regimen complexity may be a modifiable contributor to low adherence that can be targeted by future interventions to reduce self-neglect and its consequences.

scholarly journals Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252944
Author(s):  
Eri Wakai ◽  
Kenji Ikemura ◽  
Chika Kato ◽  
Masahiro Okuda
Keyword(s):  
Blood Pressure ◽  
Medication Adherence ◽  
Therapeutic Efficacy ◽  
University Hospital ◽  
Pressure Management ◽  
Medication Regimen ◽  
Good Adherence ◽  
Blood Pressure Management ◽  
Medication Regimen Complexity ◽  
Regimen Complexity

Introduction Good adherence of antihypertensives is recommended for the accomplishment of hypertension therapy. The number of medications and characteristics contributing to medication regimen complexity, such as dosage forms and dosing frequency, are known to influence medication adherence. However, the effect of medication regimen complexity on the therapeutic efficacy of medicines remains to be clarified. In the present study, we retrospectively investigated the effect of number of medications and medication regimen complexity on medication adherence and therapeutic efficacy in patients with hypertension. Methods According to the inclusion and exclusion criteria, 1,057 patients, who were on medications including antihypertensives on admission at the Mie University Hospital between July 2018 and December 2018, were enrolled in this study. Poor blood pressure management was defined if the systolic or diastolic blood pressure were ≥140 mmHg or ≥ 90 mmHg. Medication regimen complexity was quantified using the medication regimen complexity index (MRCI) score. Results Among 1,057 patients, 164 and 893 patients were categorized into poor and good adherence groups, respectively. The multivariate analyses revealed that age ≥ 71 years and oral MRCI score ≥ 19.5 but not number of oral medications were extracted as risk factors for poor medication adherence. Medication adherence and blood pressure management were poor in the group with oral MRCI score ≥ 19.5, regardless of the age. The rate of readmission was similar. Conclusion Our study is the first to demonstrate that medication regimen complexity rather than number of medications is closely related to medication adherence and blood pressure management. Hence, physicians and/or pharmacists should consider the complexity of medication regimens while modifying them.

Medication Adherence in a Cardiac Ambulatory Setting: The Challenge Continues

2017 ◽  
Vol 22 (3) ◽  
Author(s):  
Jayne Rosenberger ◽  
Esther Bernhofer ◽  
Susan McCrudden ◽  
Rosa Johnson
Keyword(s):  
Medication Adherence ◽  
Ambulatory Care ◽  
Chronic Illnesses ◽  
Ambulatory Setting ◽  
Medication Regimen ◽  
Ambulatory Care Setting ◽  
Medication Regimen Complexity ◽  
Regimen Complexity ◽  
Adherence Scale ◽  
Moderate Range

Adhering to a prescribed course of medication can be problematic for patients who take multiple prescriptions to manage chronic illnesses. This study explored the prevalence of medication adherence among patients in a cardiology ambulatory care setting using a survey-based, descriptive-comparative design. We begin this article by reviewing the medication adherence challenge. Next we describe our research method, which utilized the Morisky Medication Adherence Scale (MMAS-8©) and Medication Regimen Complexity Index (MRCI), to collect the data. Our results showed that the MMAS-8© scores of participants indicated ‘low adherence.’ A positive correlation was found between older age (>65 years) and remembering to take medications. MRCI scores were in the moderate range. Patients 65 years and older reported remembering their medications more frequently than younger patients. We also discuss our results and study limitations, and consider implications for research and practice. The conclusion suggests that medication adherence remains a significant problem. Clinicians in ambulatory care need to address the challenge of non-adherence. Although rigorous interventions are needed to promote adherence for all age patients, an emphasis on the younger population may be necessary.

scholarly journals Medication regimen complexity and its impact on medication adherence and glycemic control among patients with type 2 diabetes mellitus in an Ethiopian general hospital

2019 ◽  
Vol 7 (1) ◽  
pp. e000685 ◽  
Author(s):  
Asnakew Achaw Ayele ◽  
Henok Getachew Tegegn ◽  
Tadesse Awoke Ayele ◽  
Mohammed Biset Ayalew
Keyword(s):  
Medication Adherence ◽  
Glycemic Control ◽  
Medication Regimen ◽  
Good Glycemic Control ◽  
Medication Regimen Complexity ◽  
Complexity Index ◽  
Regimen Complexity ◽  
Patients With Diabetes ◽  
Specific Medication

BackgroundDifferent studies reported that higher diabetes-specific Medication Regimen Complexity Index (MRCI) has a negative impact on glycemic control potentially by decreasing medication adherence. However, information about regimen complexity and its association with adherence and glycemic control in Ethiopian patients with diabetes is unknown.AimTo evaluate medication regimen complexity and to assess its impact on medication adherence and glycemic control among patients with type 2 diabetes Mellitus (T2DM).MethodsA hospital-based cross-sectional design was conducted at Debre Tabor General Hospital from 1 May 2018 to 30 June 2018. Medication regimen complexity was evaluated using the 65-item validated tool called Medication Complexity Index (MRCI). Adherence was measured using Morisky Medication Adherence Scale while patients were classified as having poor or good glycemic control based on the recent record of their fasting blood glucose. Multivariable logistic regression analysis was applied to determine the association between predictive variables and outcome variables.ResultsA total of 275 patients with T2DM who meet the inclusion criteria were included in the final analysis. About 22.2% of the participants were classified as having high diabetes-specific MRCI, whereas 35.6% of the participants were classified as having high patient-level MRCI. The majority (70.5%) of the respondents were adherent to their medications, and 42.9% of the total population were categorized as having good glycemic control. According to the result of the multivariate analysis, patients with low-level and moderate-level MRCI of both diabetes-specific and patient-level MRCI were more adherent to their medication compared with patients with high MRCI. High diabetes medication regimen complexity was associated with poor glycemic control in the adjusted analyses (adjusted OR=0.276; 95% CI=0.100 o 0.759).ConclusionThe prevalence of high MRCImedication regimen complexity index is high among patients with T2DM. Patients with low and moderate regimen complexity had improved adherence. High diabetes-specific medication regimen complexity was associated with poor glycemic control. Simplification of a complex medication regimen for patients with diabetes should be sought by physicians and pharmacists to improve medication adherence and subsequent improvement in glycemic control.

scholarly journals Medication Regimen Complexity Measured by MRCI: A Systematic Review to Identify Health Outcomes

2018 ◽  
Vol 52 (11) ◽  
pp. 1117-1134 ◽  
Author(s):  
Vanessa Alves-Conceição ◽  
Kérilin Stancine Santos Rocha ◽  
Fernanda Vilanova Nascimento Silva ◽  
Rafaella Oliveira Santos Silva ◽  
Daniel Tenório da Silva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Medication Adherence ◽  
Health Outcomes ◽  
Hospital Readmission ◽  
Data Extraction ◽  
Economic Outcomes ◽  
Medication Regimen ◽  
Medication Regimen Complexity ◽  
Complexity Index ◽  
Regimen Complexity

Objective: To perform a systematic review to identify health outcomes related to medication regimen complexity as measured by the Medication Regimen Complexity Index (MRCI) instrument. Data Sources: Cochrane Library, LILACS, PubMed, Scopus, EMBASE, Open Thesis, and Web of Science were searched from January 1, 2004, until April 02, 2018, using the following search terms: outcome assessment, drug therapy, and Medication Regimen Complexity Index and their synonyms in different combinations. Study Selection and Data Extraction: Studies that used the MRCI instrument to measure medication regimen complexity and related it to clinical, humanistic, and/or economic outcomes were evaluated. Two reviewers independently carried out the analysis of the titles, abstracts, and complete texts according to the eligibility criteria, performed data extraction, and evaluated study quality. Data Synthesis: A total of 23 studies met the inclusion criteria; 18 health outcomes related to medication regimen complexity were found. The health outcomes most influenced by medication regimen complexity were hospital readmission, medication adherence, hospitalization, adverse drug events, and emergency sector visit. Only one study related medication regimen complexity with humanistic outcomes, and no study related medication regimen complexity to economic outcomes. Most of the studies were of good methodological quality. Relevance to Patient Care and Clinical Practice: Health care professionals should pay attention to medication regimen complexity of the patients because this may influence health outcomes. Conclusion: This study identified some health outcomes that may be influenced by medication regimen complexity: hospitalization, hospital readmission, and medication adherence were more prevalent, showing a significant association between MRCI increase and these health outcomes.

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