scholarly journals Leukocyte Function in COPD: Clinical Relevance and Potential for Drug Therapy

2021 ◽  
Vol Volume 16 ◽  
pp. 2227-2242
Author(s):  
Jonathan R Baker ◽  
Louise E Donnelly
Keyword(s):  
Drug Therapy ◽  
Clinical Relevance ◽  
Leukocyte Function

Clinical Relevance of P-Glycoprotein in Drug Therapy

2003 ◽  
Vol 35 (4) ◽  
pp. 417-454 ◽  
Author(s):  
Jiunn H. Lin ◽  
Masayo Yamazaki
Keyword(s):  
Drug Therapy ◽  
Clinical Relevance ◽  
P Glycoprotein

scholarly journals The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions: Drug–Gene, Drug–Gene–Gene and Drug–Drug–Gene Interactions

2021 ◽  
Vol 14 (5) ◽  
pp. 487
Author(s):  
Martina Hahn ◽  
Sibylle C. Roll
Keyword(s):  
Drug Therapy ◽  
Drug Interactions ◽  
Clinical Relevance ◽  
Adverse Drug Events ◽  
Current Evidence ◽  
Drug Event ◽  
Gene Interactions ◽  
Genetic Profile ◽  
The Impact ◽  
Pharmacokinetic Drug

Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event. This is because the clinical relevance of drug–drug interactions also depends on the genetic profile of the patient. If inhibitors or inducers of drug metabolising enzymes (e.g., CYP and UGT) are added to the drug therapy, phenoconcversion can occur. This leads to a genetic phenotype that mismatches the observable phenotype. Drug–drug–gene and drug–gene–gene interactions influence the toxicity and/or ineffectivness of the drug therapy. To date, there have been limited published studies on the impact of genetic variations on drug–drug interactions. This review discusses the current evidence of drug–drug–gene interactions, as well as drug–gene–gene interactions. Phenoconversion is explained, the and methods to calculate the phenotypes are described. Clinical recommendations are given regarding the integratation of the PGx results in the assessment of the relevance of drug interactions in the future.

Selected Abstracts of Recent Research in Stuttering

1999 ◽  
Vol 9 (1) ◽  
pp. 5-6
Author(s):  
Carrie Bain ◽  
Nan Bernstein Ratner
Keyword(s):  
Large Volume ◽  
Clinical Relevance

Due to the large volume of fluency-related publications since the last column, we have chosen to highlight those articles of highest potential clinical relevance.

A New Qualitative Defect of Leukocyte Function in Ulcerative Colitis

1960 ◽  
Vol 38 (5) ◽  
pp. 715-720 ◽  
Author(s):  
Robert J. Priest ◽  
John W. Rebuck ◽  
Gerald T. Havey ◽  
Jeanne M. Riddle
Keyword(s):  
Ulcerative Colitis ◽  
Leukocyte Function

259: Evaluation and Clinical Relevance of Prognostic Molecular Risk Factors in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 86-86
Author(s):  
Roland Bonfig ◽  
Hubertus Riedmiller ◽  
Burkhardt Kneitz ◽  
Philipp Stroebel
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Clinical Relevance

52: Clinical Relevance of Local Recurrence in Neobladders

2004 ◽  
Vol 171 (4S) ◽  
pp. 14-14
Author(s):  
Dieter R. Echtle ◽  
Elizabeth M. Mueller ◽  
Detlef H. Frohneberg
Keyword(s):  
Local Recurrence ◽  
Clinical Relevance
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