scholarly journals The Impact of Budesonide/Formoterol pMDI Medication Reminders on Adherence in Chronic Obstructive Pulmonary Disease (COPD) Patients: Results of a Randomized, Phase 4, Clinical Study

2021 ◽  
Vol Volume 16 ◽  
pp. 563-577
Author(s):  
Gerard J Criner ◽  
Therese Cole ◽  
Kristen A Hahn ◽  
Kari Kastango ◽  
James Eudicone ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Clinical Study ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
The Impact

Oxidative stress and damage to erythrocytes in patients with chronic obstructive pulmonary disease — changes in ATPase and acetylcholinesterase activity

2015 ◽  
Vol 93 (6) ◽  
pp. 574-580 ◽  
Author(s):  
Bożena Bukowska ◽  
Paulina Sicińska ◽  
Aneta Pająk ◽  
Aneta Koceva-Chyla ◽  
Tadeusz Pietras ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Red Blood Cells ◽  
Pulmonary Disease ◽  
Blood Cells ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Membrane Enzymes ◽  
Copd Patients ◽  
The Impact

The study indicates, for the first time, the changes in both ATPase and AChE activities in the membrane of red blood cells of patients diagnosed with COPD. Chronic obstructive pulmonary disease (COPD) is one of the most common and severe lung disorders. We examined the impact of COPD on redox balance and properties of the membrane of red blood cells. The study involved 30 patients with COPD and 18 healthy subjects. An increase in lipid peroxidation products and a decrease in the content of -SH groups in the membrane of red blood cells in patients with COPD were observed. Moreover, an increase in the activity of glutathione peroxidase and a decrease in superoxide dismutase, but not in catalase activity, were found as well. Significant changes in activities of erythrocyte membrane enzymes in COPD patients were also evident demonstrated by a considerably lowered ATPase activity and elevated AChE activity. Changes in the structure and function of red blood cells observed in COPD patients, together with changes in the activity of the key membrane enzymes (ATPases and AChE), can result from the imbalance of redox status of these cells due to extensive oxidative stress induced by COPD disease.

scholarly journals Impact of tobacco-related chronic obstructive pulmonary disease on developmental trajectories of comorbidities in the Taiwan population

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Te-Wei Ho ◽  
Yi-Ju Tsai ◽  
Chun-Ta Huang ◽  
Angela Shin-Yu Lien ◽  
Feipei Lai
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Developmental Trajectories ◽  
Chronic Obstructive ◽  
Control Groups ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
And Control ◽  
The Impact

AbstractComorbidities adversely affect the quality of life and survival of patients with chronic obstructive pulmonary disease (COPD), and timely identification and management of comorbidities are important in caring for COPD patients. This study aimed to investigate the impact of COPD on long-term developmental trajectories of its comorbidities. From 2010 to 2013, all spirometry-confirmed COPD patients with a 5-year follow-up period were identified as the cases. The prevalence of comorbidities and their trajectories in COPD cases were obtained and compared with those in non-COPD controls matched for age, sex, smoking status and Charlson comorbidity index (CCI). Over the study period, a total of 682 patients, 341 each in COPD and control groups were included, with a mean age of 69.1 years and 89% male. The baseline mean CCI was 1.9 for both groups of patients and significantly increased to 3.4 and 2.7 in COPD and control groups after 5 years, respectively (both P < 0.001). Through the 5-year follow-up, a significant increase in the prevalence of all comorbidities of interest was observed in the COPD cohort and the incidence was remarkably higher for hypertension [incidence rate ratio (IRR) 1.495; 95% confidence interval (CI) 1.017–2.198], malignancy (IRR 2.397; 95% CI 1.408–4.081), diabetes mellitus (IRR 2.927; 95% CI 1.612–5.318), heart failure (IRR 2.531; 95% CI 1.502–4.265) and peptic ulcer disease (IRR 2.073; 95% CI 1.176–3.654) as compared to the non-COPD matched controls. In conclusion, our findings suggest that the presence of COPD may be considered a pathogenic factor involved in the development of certain comorbidities.

scholarly journals The Impact of Community-acquired Pneumonia on Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients as Regards In-hospital Complications and Early Readmission

2020 ◽  
Vol 14 (1) ◽  
pp. 10-15
Author(s):  
Dina Ruby
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Community Acquired Pneumonia ◽  
University Hospital ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Early Readmission ◽  
The Impact

Background and Objective: Pneumonia is a major reason for hospitalization for Acute Exacerbation of Chronic Obstructive Pulmonary Disease patients (AECOPD). There is limited data available on the outcomes of AECOPD patients with or without pneumonia. Therefore, the study investigates the prognosis of AECOPD patients with or without Community-acquired Pneumonia (CAP), concerning the Length of Hospital Stay (LOS), in-hospital complications and early readmission. Methods: This study was carried out on 100 male COPD patients without CAP, 90 patients with CAP who were admitted to the chest department of Ain Shams University hospital over a 1-year period. Data collection about LOS, in-hospital complications, was recorded and they were followed for 30 days to detect acute readmission. Results: The mean age was 64± 8 years old in COPD patients without CAP to 62± 12year old in patients with CAP, LOS in COPD patients with CAP was 11.30 ± 3.23 days to 7.57 ± 2.24 in patients without CAP, COPD patients with CAP had a higher rate of complications in comparison to those without CAP as 45.6%, 13% were admitted to Intensive Care Unit (ICU) respectively, 15.6%, 3% were mechanically ventilated respectively. LOS and C- Reactive Protein (CRP) were significant causes for readmission in COPD patients with and without CAP. Conclusion: COPD patients with CAP had longer LOS and more short term complications as ICU admission, mechanical ventilation and higher readmission rate in comparison to COPD patients without CAP.

scholarly journals Comorbid Conditions in Chronic Obstructive Pulmonary Disease: Potential Therapeutic Targets for Unmet Needs

2020 ◽  
Vol 9 (10) ◽  
pp. 3078 ◽  
Author(s):  
Kazuto Matsunaga ◽  
Misa Harada ◽  
Junki Suizu ◽  
Keiji Oishi ◽  
Maki Asami-Noyama ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Clinical Characteristics ◽  
Unmet Needs ◽  
Therapeutic Targets ◽  
Chronic Obstructive ◽  
Comorbid Conditions ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
The Impact

The management of chronic obstructive pulmonary disease (COPD) has improved significantly due to advances in therapeutic agents, but it has also become apparent that there are issues that remain difficult to solve with the current treatment algorithm. COPD patients face a number of unmet needs concerning symptoms, exacerbations, and physical inactivity. There are various risk factors and triggers for these unmet needs, which can be roughly divided into two categories. One is the usual clinical characteristics for COPD patients, and the other is specific clinical characteristics in patients with comorbid conditions, such as asthma, cardiovascular disease, and bronchiectasis. These comorbidities, which are also associated with the diversity of COPD, can cause unmet needs resistance to usual care. However, treatable conditions that are not recognized as therapeutic targets may be latent in patients with COPD. We again realized that treatable traits should be assessed and treated as early as possible. In this article, we categorize potential therapeutic targets from the viewpoint of pulmonary and systemic comorbid conditions, and address recent data concerning the pathophysiological link with COPD and the impact of intervention on comorbid conditions in order to obtain evidence that could enable us to provide personalized COPD management.

scholarly journals The impact of systemic inflammation on anemia in patients with chronic obstructive pulmonary disease

2020 ◽  
Vol 73 (2) ◽  
pp. 325-328
Author(s):  
Anna V. Kovchun ◽  
Vladyslav A. Smiianov ◽  
Nataliia G. Kuchma ◽  
Vladyslava V. Kachkovska ◽  
Lyudmyla N. Prystupa
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Systemic Inflammation ◽  
Ferritin Level ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Adequate Treatment ◽  
Copd Patients ◽  
The Impact

The aim of our work was to study the indicators of systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) with anemia of chronic disease (AHD). Materials and methods: The study included 144 COPD patients (1 group) without anemia (hemoglobin> 120 g/l for women and> 130 g/l for men), and 33 patients (2 group) with COPD and ACD (hemoglobin <120 g/l for women and <130 g/l for men, soluble transferrin receptors (sTFR) – 8.7 – 28.1 nmol/l). The control group included 62 practically healthy people. All patients were evaluated for the content of ferritin, C-reactive protein (C-RP) and hepcidin. Statistical processing of the results was performed by using the SPSS-21 program. Results: Patients with COPD and ACD have a significantly higher ferritin level (p <0.001) compared to COPD patients without anemia and patients in the control group. The content of C-RP and hepcidin in patients with COPD and ACD is also significantly (p <0.001) higher compared to patients without anemia and patients in the control group. Conclusions: Determination of the content of ferritin, C-RP and hepcidin in patients with COPD may allow adequate treatment for this group of patients.

scholarly journals Association between various antioxidants in normals and chronic obstructive pulmonary disease, their alteration and impact of smoking and disease on levels of antioxidants

2019 ◽  
Vol 7 (10) ◽  
pp. 3610
Author(s):  
Kapil Bhatia ◽  
Vivek N. Ambade ◽  
Alka Sontakke ◽  
Dashrath Basannar
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Therapeutic Approaches ◽  
Obstructive Pulmonary Disease ◽  
Group I ◽  
Copd Patients ◽  
Superoxide Dismutase 3 ◽  
Group Ii ◽  
The Impact

Background: There is total alteration of various antioxidants in response to the oxidative stress, which is one of the major patho-physiologic hallmarks in chronic obstructive pulmonary disease (COPD) development. This study aims to establish the correlation between different antioxidants in normals and COPD, study the alteration in the correlation due to COPD and smoking as well as the impact of COPD and smoking on antioxidants levels.Methods: Study comprises of 96 normals as group I and 96 COPD patients as group II. The antioxidants albumin (Alb), bilirubin (Bil), uric acid (UA) ceruloplasmin (Cp), glutathione peroxidase (GSHPx), catalase (CAT) and superoxide dismutase 3 (SOD3) were estimated.Results: Significant lower serum Alb, UA, SOD3 and increased serum Cp and GSHPx were found in Group II. Significant correlation was found between Alb and UA (r=0.24); Bil and UA (r=0.26); Alb and CAT (r=0.211) and SOD3 and CAT (r=0.318) in normals. However, these correlations were altered in COPD where Alb correlates with Bil (r=0.235); UA with CAT (r=0.203) and SOD3 with GSHPx (r=-0.27). The correlation between SOD3 and CAT remained unaltered. Similar correlation of UA with Alb and Bil was observed in nonsmoker normals and between SOD3 and CAT in smoker normals. In COPD, no correlation was seen in nonsmokers, while in smokers Alb correlates with Bil (r=0.316) and SOD3 with CAT (r=0.317).Conclusions: These alterations may have clinical ramifications in further understanding the pathogenesis of COPD and developing therapeutic approaches.

scholarly journals Cardiac, ventilatory, and metabolic adjustments in chronic obstructive pulmonary disease patients during the performance of Glittre activities of daily living test

2014 ◽  
Vol 11 (4) ◽  
pp. 247-255 ◽  
Author(s):  
Andréa Tufanin ◽  
Gerson Fonseca Souza ◽  
Guilherme Rocha Tisi ◽  
Sergio Tufik ◽  
Marco Túlio de Mello ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Activities Of Daily Living ◽  
Functional Status ◽  
Pulmonary Disease ◽  
Daily Living ◽  
Lower Limbs ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
The Impact

Functional status and quality of life are measures of the chronic obstructive pulmonary disease (COPD) patient’s health status and can demonstrate the impact of the disease on the patient’s ability to perform activities of daily living (ADLs). The Glittre-ADL test was developed to evaluate the functional status of COPD patients and their ability to perform activities of daily life. The objective of this study was to evaluate the cardiac, respiratory, and metabolic adjustments and reproducibility of the Glittre ADL test performed by COPD patients. Twenty-two mild to severe COPD patients (forced expiratory volume in 1 second (FEV1): 56.6 ± 19.9% predicted; mean age: 66.3 ± 9.18 years old) were enrolled in this study. Metabolic (oxygen uptake (VO2), carbon dioxide production (VCO2), pulmonary ventilation (VE)/VCO2, and VE/VO2), ventilatory (tidal volume, respiratory rate, and VE), and cardiovascular (pulse oxygen saturation, VO2/heart rate (HR), and HR) variables, lower limbs fatigue, and dyspnea (Borg score) after each lap of two Glittre ADL test were analyzed. All metabolic, ventilatory, and cardiac variables increased their values up to the third lap and remained stable (plateau) until the end of the test (five laps; multivariate analysis); there was no difference among the time spent to complete each of the five laps in each test and between tests (total time of second test: 4 minutes and 3 seconds); the second test was 17.8 seconds (6.6%) shorter than the first one (NS). All variables were highly reproducible in the two tests (NS). At the end of the test, patients reached 87.7% of the VO2 max, 81% of VE peak, and 88.5% of the HR peak obtained from an incremental maximal test on a treadmill. The Glittre ADL test is easy for COPD patients to perform and is a highly reproducible test in COPD patients with mild to severe stages of the disease. In addition, our results suggest that it is possible to demonstrate the patient’s functional capacity with a single test of only three laps, making it faster and easier to apply and less stressful for some patients.

Microbiology of removable dentures plaque in patients with chronic obstructive pulmonary disease

2017 ◽  
Vol 67 (2) ◽  
pp. 163-181
Author(s):  
Dorota Przybyłowska ◽  
Elżbieta Mierzwińska-Nastalska
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Fungal Infections ◽  
Control Group ◽  
Chronic Obstructive ◽  
Pathogenic Microorganisms ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Removable Denture ◽  
The Impact

Introduction. The role of bacterial infection in the exacerbation of chronic obstructive pulmonary disease (COPD) has been the subject of numerous studies. The plaque of removable dentures in COPD patients is an example of bacterial-fungal biofilm that serves as a reservoir of potential pathogenic microorganisms of the respiratory system. Inadequate and improper cleaning of dentures may become a cause of COPD exacerbations. Aim of the study. To evaluate the impact of the respiratory pathogens in the denture plaque on the condition of the oral mucosa. Material and methods. The clinical status of the oral mucous membrane and the hygienic condition of dentures were assessed in 86 COPD patients and in 30 generally healthy removable denture-wearers. Microbiological and mycological examinations were conducted on the basis of material collected using direct swab from the surface of the denture. Results. Twenty-three species of potentially pathogenic microorganisms were isolated and analysed in the course of tests performed for the purpose of this study. The most frequently isolated strain, in all groups of COPD patients, was Candida albicans (from 47.6 to 60%), while in�the control group it accounted for 36.7% of the cases. In the group of COPD patients, the main isolated strains were: Candida tropicalis, Klebsiella pneumoniae, Enterobacter cloacae and Staphylococcus epidermidis. Stomatopathy complicated by fungal infections was observed both in patients with COPD (from 76% to 90%) and in the control group (53.3%). Conclusions. Denture plaque may be a potential source of bacterial and fungal infections in COPD patients. The elimination of the plaque from dentures can be an effective way of reducing the risk of exacerbations. A higher incidence of prosthetic stomatopathy complicated by fungal infection among COPD patients may be associated with the chronic use of inhaled glucocorticotherapy and home oxygen therapy.

scholarly journals Pulmonary comorbidities associated with chronic obstructive pulmonary disease

2012 ◽  
Author(s):  
Fabrizio Luppi ◽  
Bianca Beghè ◽  
Pietro Roversi
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Negative Impact ◽  
Airflow Limitation ◽  
Pulmonary Diseases ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Inhaled Therapy ◽  
The Impact

Introduction Chronic obstructive pulmonary disease (COPD) is characterized by a relatively irreversible airflow limitation caused by chronic inflammation, in most cases tobacco-related. The impact of COPD on morbidity and mortality at the single-patient level depends upon the severity of COPD symptoms and the existence of other types of systemic and/or pulmonary disease, also known as co-morbid conditions.Materials and methods This review examines the pulmonary diseases commonly associated with COPD, in terms of their prevalence, clinical features, pathogenic mechanisms, prognoses, and implications for management of COPD.Results The incidence and prevalence of various pulmonary diseases are significantly increased in patients with COPD. These conditions include symptomatic bronchiectasis, combined pulmonary fibrosis and emphysema, lung cancer, sleep-related respiratory disorders, and pulmonary embolism. Some of these concomitant respiratory diseases have an independent negative impact on the prognosis of COPD patients, and their presence has important implications for treatment of these patients.Conclusions Physicians treating patients with COPD need to be aware of these coexisting pulmonary diseases. All patients with COPD should be carefully evaluated to identify pulmonary comorbidities, since they not only influence the prognosis but also have an impact on disease management. The treatment of COPD is no longer restricted exclusively to inhaled therapy. The therapeutic approach to this disease is becoming increasingly multidimensional in view of the fact that successful management of comorbidities might positively affect the course of COPD itself.

scholarly journals Prevalence of Anxiety and Depression in Patient with Chronic Obstructive Pulmonary Disease

2018 ◽  
Vol 20 (4) ◽  
pp. 155-162
Author(s):  
Sita Sharma ◽  
U. Shakya ◽  
B. Gorkhali ◽  
S. Neupane
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Psychiatric Symptoms ◽  
Depression Scale ◽  
University Teaching ◽  
Anxiety And Depression ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
The Impact

Anxiety and depression are very common comorbidities in patients with chronic obstructive pulmonary disease (COPD). This study was aimed at documenting the prevalence anxiety and depression in COPD patient attending tertiary level hospital. A quantitative cross sectional analytical study was carried out in 221 patients with previously diagnosed COPD. Participants were recruited from respiratory OPD at Tribhuvan University Teaching Hospital, Nepal. Anxiety and depression were screened using previously validated Nepalese version of Hospital Anxiety and Depression Scale (HADS) and dyspnea was assessed using the modified Medical Research Council Dyspnea Scale (mMRC). COPD Assessment Test (CAT) was used to measure the impact of COPD on daily life. Data was analyzed using SPSS version 16. Out of 221, 140 patients (63.3%) had anxiety and 153 patients (69.2%) had depression and 133 (60.2%) had both psychiatric symptoms. Factors associated with anxiety and depression in COPD patients were age, ethnicity, educational status, marital status, current working status, duration of illness, history of previous hospitalization, number of hospitalization in previous year, domiciliary oxygen therapy comorbidities along with dyspnea, CAT score. In conclusion, the study findings suggest that anxiety and depression are highly prevalent in COPD patients.

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