scholarly journals Decreased Risk of Ischemic Heart Disease in Individuals with Severe Alpha 1-Antitrypsin Deficiency (PiZZ) in Comparison with the General Population

2020 ◽  
Vol Volume 15 ◽  
pp. 1245-1252
Author(s):  
Hanan Tanash ◽  
Magnus Ekström ◽  
Nawfal Basil ◽  
Eva Rönmark ◽  
Anne Lindberg ◽  
...  
Keyword(s):  
Heart Disease ◽  
General Population ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

scholarly journals Visible Age-Related Signs and Risk of Ischemic Heart Disease in the General Population

Circulation ◽  
2014 ◽  
Vol 129 (9) ◽  
pp. 990-998 ◽  
Author(s):  
Mette Christoffersen ◽  
Ruth Frikke-Schmidt ◽  
Peter Schnohr ◽  
Gorm B. Jensen ◽  
Børge G. Nordestgaard ◽  
...  
Keyword(s):  
Heart Disease ◽  
General Population ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Age Related

scholarly journals Response to Letter Regarding Article, “Visible Age-Related Signs and Risk of Ischemic Heart Disease in the General Population: A Prospective Cohort Study”

Circulation ◽  
2014 ◽  
Vol 130 (24) ◽  
Author(s):  
Mette Christoffersen ◽  
Ruth Frikke-Schmidt ◽  
Peter Schnohr ◽  
Gorm B. Jensen ◽  
Børge G. Nordestgaard ◽  
...  
Keyword(s):  
Cohort Study ◽  
Heart Disease ◽  
General Population ◽  
Ischemic Heart Disease ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Ischemic Heart ◽  
Age Related

Usefulness of Suita score to predict deaths from aortic aneurysm rupture and aortic dissection in general population

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y Otaki ◽  
T.W Watanabe ◽  
T.K Konta ◽  
M.W Watanabe ◽  
K.A Asahi ◽  
...  
Keyword(s):  
Heart Disease ◽  
Aortic Aneurysm ◽  
General Population ◽  
Aortic Dissection ◽  
Ischemic Heart Disease ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Aneurysm Rupture ◽  
Ischemic Heart ◽  
Framingham Risk

Abstract Background Deaths from aortic aneurysm rupture and aortic dissection are the major causes of sudden death in Japan. Suita score developed in Japan, as well as Framingham risk score, is reportedly associated with ischemic heart disease. However, it remains undetermined whether Suita score is associated with aortic aneurysm rupture and aortic dissection deaths in general population. Purpose To examine whether Suita score could predict aortic aneurysm rupture and aortic dissection deaths in general population. Methods and results We used a database of 534,414 subjects (age 40–75 years) who participated in the annual “Specific Health Check and Guidance in Japan” check-up between 2008 and 2013. The univariate and multivariate Cox proportional hazard regression analyses demonstrated that Suita score was associated with both deaths from aortic aneurysm rupture and aortic dissection after adjustment for confounding risk factors. The C indices in Suita score for aortic aneurysm rupture deaths, aortic dissection deaths and ischemic heart disease deaths were 0.8295, 0.6689, and 0.7039, respectively. The C indices in Suita score to predict aortic aneurysm rupture deaths and aortic dissection deaths were significantly greater than those in Framingham risk score. Conclusion Suita score was superior to Framingham risk score and a feasible marker for aortic aneurysm rupture and aortic dissection deaths in general population, indicating that it could serve as an identification of high-risk subjects for aortic aneurysmal rupture and aortic dissection as well as ischemic heart disease. Funding Acknowledgement Type of funding source: None

Abstract: 1081 FUNCTIONAL MUTATION IN ABCG1 PREDICTS RISK OF ISCHEMIC HEART DISEASE IN THE GENERAL POPULATION

2009 ◽  
Vol 10 (2) ◽  
pp. e293
Author(s):  
J Schou ◽  
R Frikke-Schmidt ◽  
B Nordestgaard ◽  
D Kardassis ◽  
E Thymiakou ◽  
...  
Keyword(s):  
Heart Disease ◽  
General Population ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Functional Mutation

Ischemic Heart Disease Mortality and Coronary Atherosclerosis in Hemophilia.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3192-3192 ◽  
Author(s):  
Margaret V. Ragni ◽  
Lawrence A. Nichols
Keyword(s):  
Body Mass Index ◽  
Heart Disease ◽  
General Population ◽  
Ischemic Heart Disease ◽  
Cause Of Death ◽  
Coronary Stenosis ◽  
Coronary Atherosclerosis ◽  
Ischemic Heart ◽  
Disease Mortality ◽  
Ischemic Heart Disease Mortality

Abstract Mortality in individuals with hemophilia is 2.7-fold higher than the general population. By contrast, ischemic heart disease mortality in this group is 60% lower than in the general population. The reason for these differences is not known. While high VIII:C is associated with thrombotic risk, and low VIII:C is associated with bleeding risk, it remains unproven whether low VIII:C is protective against atherosclerosis or cardiovascular morbidity or mortality. We, therefore, conducted a case-control study to compare coronary atherosclerosis at autopsy in 14 hemophilic men who died between 1983 and 1992, on whom autopsies were available, and 42 HIV-negative age-, gender-, and race-matched non-hemophilic controls. The mean age at death in hemophilic cases was 40 ± 4 yr (19–74), as compared with 41 ± 2 yr (18 to 75) in the controls, p > 0.25. The cause of death in cases was AIDS in 7 (50.0%), hepatitis C liver disease in 4 (28.6%), CNS bleeding in 2 (14.3%), and cancer in 1 (7.1%). The cause of death in controls was cardiopulmonary disease in 14 (33.3%), infection in 13 (30.9%), cancer in 4 (9.5%), organ failure in 4 (9.5%), and other in 7 (16.7%). None (0%) of the hemophilia cases had coronary disease symptoms vs. 2 (4.8%) of the controls, p = 0.559. Ten (71.4%) of the cases were HIV-infected, but none had received HAART therapy. Twelve cases had severe hemophilia (VIII < 0.01 U/ml), one moderate disease (VIII = 0.01–0.04 U/ml), and one mild disease (VIII ≥ 0.05 U/ml). None of the cases had diabetes or hypercholesterolemia (> 220 mg/dl); five (35.7%) were smokers, five (35.7%) were hypertensive (systolic > 140 and/or diastolic > 80 mm Hg), and three (21.4%) were obese (body mass index > 25 kg/m2). Body mass index, mean 23.84 ± 0.84 kg/m2, and blood pressure, mean systolic, 129 ± 6 mm Hg, and mean diastolic, 82 ± 3 mm Hg, increased with age, r = 0.439, r = 0.488, r = 0.209, respectively, but not significantly so, p > 0.05. Intraluminal coronary stenosis was assessed by a semi-quantitative scoring system, with 0 = minimal (< 25%), 1= mild (≥ 25%), 2 = moderate (≥ 50%), and 3 = severe (≥ 75%). Coronary stenosis was detected in 11 of 14 (78.6%) hemophilic cases and in 25 of 42 (59.5%) controls, p = 0.118. There was no difference in the proportion with > 75% narrowing, 2 of 14 (14.3%) cases vs. 9 of 42 (21.4%) controls, respectively, p = 0.272. The overall mean stenosis score in hemophilic cases was 1.1 ± 0.2, not different from that in non-hemophilic controls, 1.2 ± 0.2, p > 0.25. The degree of intraluminal narrowing increased with age in cases, r = 0.773, p < 0.01, and in controls, r = 0.694, p < 0.01. There was no difference between age and coronary narrowing between groups, p = 0.928. In conclusion, the prevalence of coronary atherosclerosis in hemophilic men is comparable to that in age-, gender-, and race-matched non-hemophilic controls. Although factor VIII:C does not appear to promote atherogenesis, it is possible, although not proven, that low or missing VIII:C in hemphilia may be protective against thrombotic occlusion of atherosclerotic vessels by interfering with fibrin formation, thereby affording protection from ischemic heart disease mortality.

scholarly journals Blood Pressure, Risk of Ischemic Cerebrovascular and Ischemic Heart Disease, and Longevity in α1-Antitrypsin Deficiency

Circulation ◽  
2003 ◽  
Vol 107 (5) ◽  
pp. 747-752 ◽  
Author(s):  
Morten Dahl ◽  
Anne Tybjærg-Hansen ◽  
Henrik Sillesen ◽  
Gorm Jensen ◽  
Rolf Steffensen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Antitrypsin Deficiency
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