scholarly journals Evaluating Patient Preferences of Maintenance Therapy for the Treatment of Chronic Obstructive Pulmonary Disease: A Discrete Choice Experiment in the UK, USA and Germany

2020 ◽  
Vol Volume 15 ◽  
pp. 595-604 ◽  
Author(s):  
Hannah B Lewis ◽  
Melanie Schroeder ◽  
Necdet B Gunsoy ◽  
Ellen M Janssen ◽  
Samuel Llewellyn ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Maintenance Therapy ◽  
Pulmonary Disease ◽  
Discrete Choice Experiment ◽  
Discrete Choice ◽  
Patient Preferences ◽  
Choice Experiment ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The Uk

scholarly journals Maintenance inhaler therapy preferences of patients with asthma or chronic obstructive pulmonary disease: a discrete choice experiment

Thorax ◽  
2020 ◽  
Vol 75 (9) ◽  
pp. 735-743 ◽  
Author(s):  
Tommi Tervonen ◽  
Natalia Hawken ◽  
Nicola A Hanania ◽  
Fernando J Martinez ◽  
Sebastian Heidenreich ◽  
...  
Keyword(s):  
Discrete Choice Experiment ◽  
Discrete Choice ◽  
Patient Preferences ◽  
Choice Experiment ◽  
Inhaled Corticosteroids ◽  
Symptom Relief ◽  
Chronic Obstructive ◽  
Onset Of Action ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

BackgroundA variety of maintenance inhaler therapies are available to treat asthma and COPD. Patient-centric treatment choices require understanding patient preferences for the alternative therapies.MethodsA self-completed web-based discrete choice experiment was conducted to elicit patient preferences for inhaler device and medication attributes. Selection of attributes was informed by patient focus groups and literature review.ResultsThe discrete choice experiment was completed by 810 patients with asthma and 1147 patients with COPD. Patients with asthma most valued decreasing the onset of action from 30 to 5 min, followed by reducing yearly exacerbations from 3 to 1. Patients with COPD most and equally valued decreasing the onset of action from 30 to 5 min and reducing yearly exacerbations from 3 to 1. Both patients with asthma and patients with COPD were willing to accept an additional exacerbation in exchange for a 15 min decrease in onset of action and a longer onset of action in exchange for a lower risk of adverse effects from inhaled corticosteroids. Patients with asthma and COPD valued once-daily over twice-daily dosing, pressurised inhalers over dry powder inhalers and non-capsule priming over single-use capsules, although these attributes were not valued as highly as faster onset of action or reduced exacerbations.ConclusionsThe most important maintenance inhaler attributes for patients with asthma and COPD were fast onset of symptom relief and a lower rate of exacerbations. Concerns about safety of inhaled corticosteroids and device convenience also affected patient preferences but were less important.

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