scholarly journals Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease

2019 ◽  
Vol Volume 14 ◽  
pp. 1669-1680 ◽  
Author(s):  
Zhao-Ji Meng ◽  
Jiang-Hua Wu ◽  
Mei Zhou ◽  
Sheng-Wen Sun ◽  
Shuai-Ying Miao ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
T Cell ◽  
Pulmonary Disease ◽  
Peripheral Blood ◽  
Foxp3 Expression ◽  
Cd4 T Cell ◽  
Cell Populations ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Potential Biomarker

scholarly journals Methylation of SERPINA1 gene promoter may predict chronic obstructive pulmonary disease in patients affected by acute coronary syndrome

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
John Charles Rotondo ◽  
Giorgio Aquila ◽  
Lucia Oton-Gonzalez ◽  
Rita Selvatici ◽  
Paola Rizzo ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Acute Coronary Syndrome ◽  
Pulmonary Disease ◽  
Blood Cells ◽  
Gene Promoter ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Coronary Syndrome ◽  
Copd Patients ◽  
Potential Biomarker

Abstract Background Diagnostic biomarkers for detecting chronic obstructive pulmonary disease (COPD) in acute coronary syndrome (ACS) patients are not available. SERPINA1, coding for the most potent circulating anti-inflammatory protein in the lung, has been found to be differentially methylated in blood cells from COPD patients. This study aimed to investigate the methylation profile of SERPINA1 in blood cells from ACS patients, with (COPD+) or without COPD (COPD−). Methods Blood samples were from 115 ACS patients, including 30 COPD+ and 85 COPD− according to lung function phenotype, obtained with spirometry. DNA treated with sodium bisulfite was PCR-amplified at SERPINA1 promoter region. Methylation analysis was carried out by sequencing the PCR products. Lymphocytes count in ACS patients was recorded at hospital admission and discharge. Results SERPINA1 was hypermethylated in 24/30 (80%) COPD+ and 48/85 (56.5%) COPD− (p < 0.05). Interestingly, at hospital discharge, lymphocytes count was higher in COPD− patients carrying SERPINA1 hypermethylated (1.98 × 103 ± 0.6 cell/µl) than in COPD− carrying SERPINA1 hypomethylated (1.7 × 103 ± 0.48 cell/µl) (p < 0.05). Conclusions SERPINA1 is hypermethylated in blood cells from COPD+ patients. COPD− carrying SERPINA1 hypermethylated and high lymphocytes count may be at risk of COPD development. Therefore, SERPINA1 hypermethylation may represent a potential biomarker for predicting COPD development in ACS patients.

OR.37. Th17 Response Polarization in Peripheral Blood and Bronchoalveolar Fluid of Patients with Chronic Obstructive Pulmonary Disease

2009 ◽  
Vol 131 ◽  
pp. S17
Author(s):  
María Inés Vargas-Rojas ◽  
Raul Sansores ◽  
Alejandra Ramirez ◽  
Luis Jiménez ◽  
Diana Torres García ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Peripheral Blood ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Th17 Response ◽  
Bronchoalveolar Fluid
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