scholarly journals Effectiveness of water-based Liuzijue exercise on respiratory muscle strength and peripheral skeletal muscle function in patients with COPD

2018 ◽  
Vol Volume 13 ◽  
pp. 1713-1726 ◽  
Author(s):  
Weibing Wu ◽  
Xiaodan Liu ◽  
Jingxin Liu ◽  
Peijun Li ◽  
Zhenwei Wang
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Muscle Function ◽  
Respiratory Muscle ◽  
Respiratory Muscle Strength ◽  
Skeletal Muscle Function ◽  
Water Based

scholarly journals Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
C. Homer-Bouthiette ◽  
L. Xiao ◽  
Marja M. Hurley
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Muscle Strength ◽  
Fibroblast Growth Factor ◽  
Muscle Function ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Skeletal Muscle Function ◽  
Age Related ◽  
Gait Disturbances

AbstractFibroblast growth factor 2 (FGF2) is important in musculoskeletal homeostasis, therefore the impact of reduction or Fgf2 knockout on skeletal muscle function and phenotype was determined. Gait analysis as well as muscle strength testing in young and old WT and Fgf2KO demonstrated age-related gait disturbances and reduction in muscle strength that were exacerbated in the KO condition. Fgf2 mRNA and protein were significantly decreased in skeletal muscle of old WT compared with young WT. Muscle fiber cross-sectional area was significantly reduced with increased fibrosis and inflammatory infiltrates in old WT and Fgf2KO vs. young WT. Inflammatory cells were further significantly increased in old Fgf2KO compared with old WT. Lipid-related genes and intramuscular fat was increased in old WT and old Fgf2KO with a further increase in fibro-adipocytes in old Fgf2KO compared with old WT. Impaired FGF signaling including Increased β-Klotho, Fgf21 mRNA, FGF21 protein, phosphorylated FGF receptors 1 and 3, was observed in old WT and old Fgf2KO. MAPK/ ERK1/2 was significantly increased in young and old Fgf2KO. We conclude that Fgf2KO, age-related decreased FGF2 in WT mice, and increased FGF21 in the setting of impaired Fgf2 expression likely contribute to impaired skeletal muscle function and sarcopenia in mice.

Corticosteroids and skeletal muscle function in cystic fibrosis

2003 ◽  
Vol 95 (4) ◽  
pp. 1379-1384 ◽  
Author(s):  
Sinead C. Barry ◽  
Charles G. Gallagher
Keyword(s):  
Skeletal Muscle ◽  
Cystic Fibrosis ◽  
Muscle Strength ◽  
Muscle Weakness ◽  
Muscle Function ◽  
Knee Extensor ◽  
Skeletal Muscle Function ◽  
Peripheral Muscle ◽  
Causative Effect ◽  
Concomitant Medications

Patients with cystic fibrosis (CF) have reduced peripheral muscle strength. We tested the hypothesis that steroid treatment contributes to muscle weakness in adults with CF. Twenty-three stable CF patients were studied. Measurements included knee extensor (KE), knee flexor (KF), elbow flexor (EF), handgrip (HG), expiratory (Pemax), and inspiratory (Pimax) muscle strengths. Spirometry, body mass index (BMI), and days spent in hospital over the preceding 12 mo (DH) were also measured. Average daily dose of prednisolone over the preceding 12 mo (ADD) was 5.1 mg/day. Pearson's correlation analysis revealed that ADD correlated significantly with skeletal muscle strengths (KF%, r = -0.63, P < 0.01) with the exception of HG%. These findings are independent of age, BMI, pulmonary function, and DH. Multiple-regression analysis revealed that ADD was the most significant predictor of all measures of skeletal muscle function except HG%. It was independently responsible for 54% of the variance in Pimax%, for 46% of the variance in Pemax%, for 45% of the variance in KE%, for 39% of the variance in KF%, and for 41% of the variance in EF%. Concomitant medications (e.g., theophylline) were shown to have no causative effect. Corticosteroids contribute to the skeletal muscle weakness seen in CF patients. The correlation of proximal muscle strength, but not HG strength, with steroid dosage further supports a cause-effect relationship.

Impairment of respiratory muscle function in pulmonary hypertension

2007 ◽  
Vol 114 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Hans-Joachim Kabitz ◽  
Anja Schwoerer ◽  
Hinrich-Cordt Bremer ◽  
Florian Sonntag ◽  
Stephan Walterspacher ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Muscle Strength ◽  
Muscle Function ◽  
Respiratory Muscle ◽  
World Health ◽  
Walking Distance ◽  
Respiratory Muscle Strength ◽  
Control Subjects ◽  
Respiratory Muscle Function ◽  
Health Organization

It has been suggested that impaired respiratory muscle function occurs in patients with PH (pulmonary hypertension); however, comprehensive investigations of respiratory muscle function, including the application of non-volitional tests, needed to verify impairment of respiratory muscle strength in patients with PH have not yet been performed. In the present study, respiratory muscle function was assessed in 31 patients with PH (20 females and 11 males; mean pulmonary artery pressure, 51±20 mmHg; median World Health Organization class 3.0±0.5; 25 patients with pulmonary arterial hypertension and six patients with chronic thromboembolic PH) and in 31 control subjects (20 females and 11 males) well-matched for gender, age and BMI (body mass index). A 6-min walking test was performed to determine exercise capacity. Volitionally assessed maximal inspiratory (7.5±2.1 compared with 6.2±2.8 kPa; P=0.04) and expiratory (13.3±4.2 compared with 9.9±3.4 kPa; P<0.001) mouth pressures, sniff nasal (8.3±1.9 compared with 6.6±2.2 kPa; P=0.002) and transdiaphragmatic (11.3±2.5 compared with 8.7±2.5 kPa; P<0.001) pressures, non-volitionally assessed twitch mouth (1.46±0.43 compared with 0.97±0.41 kPa; P<0.001) and transdiaphragmatic (2.08±0.55 compared with 1.47±0.72 kPa; P=0.001) pressures during bilateral anterior magnetic phrenic nerve stimulation were markedly lower in patients with PH compared with control subjects. Maximal inspiratory mouth (r=0.58, P<0.001) and sniff transdiaphragmatic (r=0.43, P=0.02) pressures were correlated with the 6-min walking distance in patients with PH. In conclusion, the present study provides strong evidence that respiratory muscle strength is reduced in patients with PH compared with well-matched control subjects. Furthermore, the 6-min walking distance is significantly linked to parameters assessing inspiratory muscle strength.

scholarly journals The Effect of Habitual Exercise on Respiratory-Muscle Function in Older Adults

2005 ◽  
Vol 13 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Mark L. Watsford ◽  
Aron J. Murphy ◽  
Matthew J. Pine ◽  
Aaron J. Coutts
Keyword(s):  
Older Adults ◽  
Muscle Strength ◽  
Muscle Function ◽  
Respiratory Muscle ◽  
Endurance Capacity ◽  
Respiratory Muscle Strength ◽  
Exercise Participation ◽  
Inspiratory Muscles ◽  
Respiratory Muscle Function ◽  
Habitual Exercise

Older adults’ participation in habitual exercise might be affected by alterations to respiratory mechanics such as decreased respiratory-muscle strength. This reduction can cause a decrease in efficiency of the ventilatory pump, potentially compromising exercise participation. This research examined the role of habitual exercise in respiratory-muscle function and the associated implications for exercise performance. Seventy-two healthy older adults (36 men, 64.9 ± 8.6 years, 177.2 ± 8.4 cm, 82.5 ± 11.9 kg; 36 women, 64.9 ± 9.5 years, 161.7 ± 6.4 cm, 61.6 ± 9.2 kg) undertook respiratory-function and walking-performance tests. Active men and women achieved higher scores than their inactive counterparts for all tests except spirometry, where no differences were evident. The results indicate that a significant amount of the elevated fitness level might be accounted for by increased endurance capacity of the inspiratory muscles. Inactive older individuals might be at risk for inadequate respiratory-muscle strength, so interventions should be considered.

Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e13002-e13002
Author(s):  
L. Jones ◽  
A. Friedman ◽  
M. West ◽  
S. Mabe ◽  
J. Fraser ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Muscle Strength ◽  
Malignant Glioma ◽  
Exercise Capacity ◽  
Muscle Function ◽  
Isokinetic Strength ◽  
Safe Procedure ◽  
Skeletal Muscle Function ◽  
Cross Sectional

e13002 Background: The neuropsychological impact of malignant glioma is well documented; the physiological and functional effects are not known. We conducted a pilot study to quantitatively assess cardiorespiratiory fitness, skeletal muscle function, and body composition of patients with primary malignant glioma. Methods: Using a cross-sectional design, patients with clinically stable postsurgical (10 ± 7 days post surgery) high-grade glioma (HGG; n=25) and low-grade glioma (LGG) were studied. Participants performed a cardiopulmonary exercise test (CPET) with expired gas analysis to assess peak exercise capacity (VO2peak) and other parameters of cardiovascular function. Other physiological outcomes included skeletal muscle cross-sectional area (CSA; magnetic resonance imaging), isokinetic muscle strength (isokinetic dynamometer), and body composition (air displacement plethysmography). QOL was assessed by the Functional Assessment of Cancer Therapy-Brain scale (FACT-BR). Results: CPET was a feasible and safe procedure for malignant glioma patients with no serious adverse events. Peak VO2 indexed to total body weight and lean body mass for both groups was 13.0 mL.min-1 and 19 mL.min-1; the equivalent to 59% and 38% below age and sex-predicted normative values, respectively. Skeletal muscle isokinetic strength was significantly lower in HGG relative to LGG patients (83 vs. 125 Nm, p=.025) and predicted peak VO2 (r = 0.44, p<0.05). In patients with HGG, only self-reported exercise behavior was correlated with QOL (r = 0.42; p=.046) while sex (male) (r = 0.44; p=.037), lean mass (r = -0.41; p=.049), and VO2peak (r = -0.40; p=.052) were associated with fatigue. Conclusions: CPET is a safe and feasible tool to evaluate physical functioning in select patients with malignant glioma. Postsurgical glioma patients have markedly reduced exercise capacity, isokinetic strength and CSA. Muscle strength is an important contributor to poor VO2peak in this population. Prospective studies are now required to determine whether such abnormalities influence prognosis as well as test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction. No significant financial relationships to disclose.

Relationship between respiratory muscle function and age, sex, and other factors

1989 ◽  
Vol 66 (2) ◽  
pp. 943-948 ◽  
Author(s):  
H. I. Chen ◽  
C. S. Kuo
Keyword(s):  
Muscle Strength ◽  
Pulmonary Function ◽  
Duty Cycle ◽  
Muscle Function ◽  
Respiratory Muscle ◽  
Forced Expiratory Volume ◽  
Inspiratory Muscle ◽  
Muscle Endurance ◽  
Respiratory Muscle Strength ◽  
Respiratory Muscle Function

To investigate the effects of gender and age on respiratory muscle function, 160 healthy volunteers (80 males, 80 females) were divided into four age groups. Twenty-eight of the male subjects were smokers. After the subjects were familiarized with the experimental procedure, respiratory muscle strength, inspiratory muscle endurance, and spirometric function, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, tidal volume, breathing rate, and duty cycle, were measured. The respiratory muscle strength was indicated by the maximal static inspiratory and expiratory pressures (PImmax and PEmmax). Inspiratory muscle endurance was determined by the time the subject was able to sustain breathing against an inspiratory pressure load on a modified Nickerson-Keens device. The results showed that 1) except for inspiratory muscle endurance and FEV1/FVC, men had greater respiratory muscle and pulmonary functions than women, 2) respiratory muscle function and pulmonary function decreased with age, 3) smoking tended to lower duty cycle and FEV1/FVC and to enhance PE,mmax, and 4) inspiratory muscle endurance was greater in men who were physically active than in those who were sedentary. Therefore we conclude that there are sexual and age differences in respiratory muscle strength and pulmonary function and that smoking or physical activity may affect respiratory muscle function.

scholarly journals Measuring skeletal muscle strength and endurance, from bench to bedside

2008 ◽  
Vol 31 (5) ◽  
pp. 307 ◽  
Author(s):  
Didier Saey ◽  
Thierry Troosters
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Exercise Training ◽  
Muscle Weakness ◽  
Muscle Function ◽  
Muscle Endurance ◽  
Muscle Dysfunction ◽  
Skeletal Muscle Function ◽  
Peripheral Muscle ◽  
Skeletal Muscle Strength

Peripheral muscle dysfunction is a recognized and important systemic consequence of many chronic diseases. Peripheral muscle weakness is associated with excess utilization of health care recourses, morbidity and /or mortality in patients with COPD, congestive heart failure, liver and frail elderly. In the latter group, muscle weakness was associated with significant increase in falling and falling related injury. Exercise training does enhance skeletal muscle function and exercise performance. In addition, patients who start a training program with impaired skeletal muscle function may be more likely to respond adequately to an exercise training program. It is beyond the scope of the present review to discuss in detail the factors that may contribute to muscle dysfunction in chronic conditions. Clearly, muscle weakness is multi-factorial. Factors associated with skeletal muscle force are general factors (such as age, body weight, sex), disease related factors (such as inactivity) and disease specific factors (for example in COPD drug treatment, i.e. corticosteroid treatment, inflammation, oxidative stress and hypoxia have been shown to contribute to muscle dysfunction). This review will focus on the different ways to assess skeletal muscle function in patients with chronic disease. More specifically, techniques to assess skeletal muscle strength, skeletal muscle endurance and skeletal muscle fatigue will be discussed. For the American College of Sport Medicine (ACSM) not only muscle strength but also muscle endurance are health- related fitness components. Loss in one of these muscle characteristics results in impaired muscle. Muscle function tests are very specific to the muscle group tested, the type of contraction, the velocity of muscle motion, the type of equipment and the joint range of motion. Results of any test are specific to the procedures used. Individuals should participate in familiarization sessions with the equipment, and adhere to a specific protocol in order to obtain a true and reliable score. A change in one’s muscular fitness over time can be based on the absolute value of the external force (Newton (N)), but when comparisons are made between individuals, the values should be expressed as relative values (percentage of a predicted normal value). In both cases, caution must be taken in the interpretation of the result because the norms may not include a representative sample of the individual being measured, a standardized protocol may be absent, or the exact test being used may differ.

PULMONARY PHYSIOLOGY IN CHILDREN

PEDIATRICS ◽  
1960 ◽  
Vol 25 (5) ◽  
pp. 766-774
Author(s):  
C. D. Cook ◽  
H. Barrie ◽  
S. A. DeForest ◽  
P. J. Helliesen
Keyword(s):  
Muscle Strength ◽  
Idiopathic Scoliosis ◽  
Muscle Function ◽  
Respiratory Muscle ◽  
Vertebral Column ◽  
Flow Resistance ◽  
Vital Capacity ◽  
Respiratory Muscle Strength ◽  
Lung Volumes ◽  
Pulmonary Physiology

Measurements of lung volumes, compliance and resistance, and effective respiratory muscle strength have been carried out in a series of patients with idiopathic scoliosis, scoliosis secondary to poliomyelitis and scoliosis secondary to abnormalities of the vertebral column. The patients with idiopathic scoliosis showed, in general, moderate reductions in vital capacity, while those with poliomyelitis and associated paralysis showed more marked decreases. Residual volume on the average was essentially unchanged in both groups. Compliance was only moderately but consistently reduced in both groups while flow-resistance was only slightly to moderately increased. In the group of patients with idiopathic scoliosis, effective respiratory muscle strength was normal for given lung volumes but inspiratory strength was subnormal. Serial studies show that after fusion, the patients tended to have a further decrease both in respiratory muscle function and in lung volumes. The frequently serious pulmonary dysfunction accompanying the scoliosis secondary to vertebral abnormalities is illustrated.

scholarly journals Muscle function and quality of life in the Crohn’s disease

2017 ◽  
Vol 30 (2) ◽  
pp. 337-345 ◽  
Author(s):  
Andrea Lemos Cabalzar ◽  
Diana Junqueira Fonseca Oliveira ◽  
Maycon de Moura Reboredo ◽  
Fernando Azevedo Lucca ◽  
Júlio Maria Fonseca Chebli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Muscle Strength ◽  
Muscle Function ◽  
Respiratory Muscle ◽  
Control Group ◽  
Respiratory Muscle Strength ◽  
Peripheral Muscle ◽  
Sf 36 ◽  
Inflammatory Bowel

Abstract Introduction: Crohn’s disease (CD) is an inflammatory bowel disease, marked by exacerbations and remissions periods. Peripheral manifestations in CD may be present with the syndrome of skeletal muscle dysfunction (SMD), which is characterized by loss of muscle strength, fatigue complain, limited exercise capacity and impaired quality of life of these patients. Objective: Evaluate muscle strength, physical capacity and quality of life of patients with CD and compare them with healthy controls. Methods: 18 patients CD and 12 healthy controls matched for age and sex were involved. Peripheral muscle strength evaluated by handgrip strength of the dominant hand and respiratory muscle strength by measures of respiratory muscle strength (maximal inspiratory/expiratory pressure - MIP and MEP). Exercise capacity evaluated by Shuttle test (ST) and the quality of life by the Short-form 36 (SF-36) and by the Inflammatory Bowel Disease Questionnaire (IBDQ). Results: Patients with CD presented a lower respiratory muscle strength (MIP = -68.93 ± 26.61 vs 29.63 ± -100 cmH2O, p = 0.0013 and MEP = 81.07 ± 30.26 vs 108 ± 25.30 cmH2O, p = 0.032) and a tendency the lower peripheral muscle strength (31.72 ± 8.55 vs 39.00 ± 13.37 kgf, p = 0.09). In addition, CD patients presented worse physical capacity on the ST compared to the control group (513.7 ± 237m vs 983.0 ± 263m, p < 0.05) and worse quality of life in 7 of 8 domains of the SF-36 and in all dimensions of the IBDQ. Conclusion: Patients with CD showed muscle functional impairment and poorer quality of life compared to healthy control group. These findings suggest that the assessment and maybe interventions in the muscle function must be used in clinical practice.

Sign in / Sign up

Export Citation Format

Share Document