scholarly journals IL-26 in the induced sputum is associated with the level of systemic inflammation, lung functions and body weight in COPD patients

2018 ◽  
Vol Volume 13 ◽  
pp. 2569-2575 ◽  
Author(s):  
Lesia Savchenko ◽  
Marina Mykytiuk ◽  
Mathieu Cinato ◽  
Helene Tronchere ◽  
Oxana Kunduzova ◽  
...  
Keyword(s):  
Body Weight ◽  
Systemic Inflammation ◽  
Induced Sputum ◽  
Copd Patients ◽  
Lung Functions

RELATION OF THE MARKERS OF MYOCARDIAL DYSFUNCTION AND SYSTEMIC INFLAMMATION WITH STRUCTURAL AND FUNCTIONAL PARAMETERS OF THE LUNGS IN MYOCARDIAL INFARCTION PATIENTS

2018 ◽  
Vol 17 (2) ◽  
pp. 24-28
Author(s):  
O. M. Polikutina ◽  
Y. S. Slepynina ◽  
E. D. Bazdyrev ◽  
V. N. Karetnikova ◽  
O. L. Barbarach
Keyword(s):  
Myocardial Infarction ◽  
Systemic Inflammation ◽  
Myocardial Dysfunction ◽  
Control Group ◽  
Chronic Obstructive ◽  
Lung Pathology ◽  
Functional Changes ◽  
Functional Parameters ◽  
Lung Capacity ◽  
Copd Patients

Aim. To evaluate the structural and functional changes in the lungs of ST elevation myocardial infarction (STEMI) patients with absence or presence of chronic obstructive lung disease (COPD), and the relation with myocardial dysfunction and systemic inflammation.Material and methods. Totally, 189 STEMI patients included: group 1 — STEMI with COPD of moderate and mild grade, 2 — STEMI with no lung pathology. Groups were comparable by clinical and anamnestic parameters. Assessment of lung function and blood collection were done at 10­12 day of STEMI. For comparison of the parameters representing structural and functional changes in the lungs and comparison of C­reactive protein (CRP), N­terminal pro­brain natriuretic peptide (NT­proBNP) concentration, a control group was formed with no pulmonary pathology, comparable by age and sex with the STEMI patients.Results. In COPD patients, higher values revealed of the parameters representing the part of residual volumes in pulmonary structure. Higher residual volume (RV) was found also in STEMI and no COPD comparing to controls, however the relation RV/TLC (total lung capacity) was not higher than normal range. In both groups there were lower values of diffusion lung capacity (DLCO) comparing to controls. The lowest DLCO found in COPD patients. Concentration of NT­proBNP (H=41,6; p<0,001) and CRP (H=38,6; p<0,001) in COPD was significantly higher in STEMI with no COPD patients than in controls. The negative correlations found for NT­proBNP and CRP with forced expiratory volume 1 sec, FEV/FVC1, DLCO, and positive — with the values of thoracic volume, RV/TLC.Conclusion. In STEMI patients the increase revealed of residual lung volumes. Mostly the level of residual volumes is high in STEMI and COPD patients. There are associations of NT­proBNP and CRP with structural and functional parameters of the lungs regardless of COPD.

STUDY OF HS-CRP AND TNF-A LEVELS IN COPD PATIENTS ACCOMPANIED WITH CORONARY ARTERY DISEASE

2014 ◽  
pp. 48-56
Author(s):  
Van Thi Tran ◽  
Van Bang Le ◽  
Thị Thu Huong Hoang
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
Chronic Obstructive ◽  
Low Grade ◽  
Cross Sectional ◽  
Copd Patients ◽  
Coronary Artery Angiography ◽  
Hs Crp ◽  
Artery Disease

Aim: Some studies have linked the present of chronic obstructive oulmonary disease (COPD) to coronary artery disease (CAD). Low grade systemic inflammation occurs in patients with COPD as well as patients with CAD. This study was designed to find out the concentration differences of hs-CRP and TNF-a in patients having both chronic obstructive pulmonary and coronary artery diseases with those having either. Methods: A cross - sectional descriptive study was conducted in 200 patients undergoing a coronary artery angiography in the Heart Institute, Thong Nhat Hospital and 115 People Hospital. COPD was diagnosed using GOLD classification. Result: Our study had shown that the levels of hs-CRP and TNF-a were statistically increased in patients with COPD, CAD as well as in patients who had COPD with CAD (p<0,05). The levels of hs-CRP were higher in CAD than in COPD nad the levels of TNF-a were higher in COPD than in CAD. In patients with COPD and CAD, there were increased the levels of both hs-CRP and TNF-a in serum. Conclusion: Systemic inflammation presents in both COPD and CAD. Key words: hs-CRP, TNF-a, coronary artery disease (CAD).

scholarly journals Relationship between vitamin D and lung function, physical performance and balance on patients with stage I-III chronic obstructive pulmonary disease

2015 ◽  
Vol 61 (2) ◽  
pp. 132-138 ◽  
Author(s):  
Tuncay Yumrutepe ◽  
Zeynep Ayfer Aytemur ◽  
Ozlem Baysal ◽  
Hulya Taskapan ◽  
Cagatay M. Taskapan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Vitamin D Deficiency ◽  
Physical Performance ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Lung Functions ◽  
Knee Muscle ◽  
Knee Muscle Strength

Summary Objectives: vitamin D is important for muscle function and it affects different aspects of muscle metabolism. This study aim to determine whether serum 25(OH) D levels are related to lung functions, physical performance and balance in patients with chronic obstructive pulmonary disease (COPD). Methods: in 90 patients with COPD and 57 healthy controls lung function tests, physical performance tests (time up and go, gait velocity test, sit-to-stand test, isometric strength, isokinetic strength), static (functional reach test) and dynamic (time up and go) balance tests and the association of 25(OH)D levels with lung functions, physical performance and balance were evaluated. Results: the COPD patients had significantly more deficit in physical function and balance parameters, and in dynamic balance test (p<0.005). Isokinetic knee muscle strength (flexor and extensor) in COPD patients was significantly lower than in the controls (p<0.05); FEV1 (p=0.008), FVC (p=0.02), FEV1/FVC (p=0.04), TLC (p=0.01) were lower in COPD patients with vitamin D deficiency [25(OH) D less than 15ng/mL] than in COPD patients without vitamin D deficiency. Hand grip test (p=0.000) and isokinetic knee muscle strength (flexor and extensor) (p<0.05) were also lower in COPD patients with vitamin D deficiency. Vitamin D deficiency was more pronounced in patients with stage III COPD (p<0.05). Conclusion: patients with COPD had worst physical functioning, poor balance and less muscle strength. Severe disturbed lung and peripheral muscle functions are more pronounced in COPD patients with vitamin D deficiency.

scholarly journals Suppressor of Variegation 3-9 Homologue 1 Impairment and Neutrophil-skewed Systemic Inflammation Are Associated with Comorbidities in COPD

2020 ◽  
Author(s):  
Tzu-Tao Chen ◽  
Sheng-Ming Wu ◽  
Kuan-Yuan Chen ◽  
Chien-Hua Tseng ◽  
Shu-Chuan Ho ◽  
...  
Keyword(s):  
Blood Cell ◽  
Clinical Outcomes ◽  
Systemic Inflammation ◽  
Mononuclear Cells ◽  
Chronic Obstructive ◽  
Th2 Response ◽  
Neutrophilic Inflammation ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Copd Patients

Abstract BACKGROUND: Systemic manifestations and comorbidities are characteristics of chronic obstructive pulmonary disease (COPD) and are probably due to systemic inflammation. The histone methyltransferase SUV39H1 controls the Th1/Th2 balance. We previously reported that reduced SUV39H1 expression contributed to abnormal inflammation in COPD.METHODS: To assess whether impaired SUV39H1 expression in COPD patients leads to neutrophilic inflammation, downstream responses to IL-8 and suppression of Th2 responses, the SUV39H1 levels in peripheral blood mononuclear cells (PBMCs) from 13 healthy subjects and 30 COPD patients were measured by immunoblotting. Clinical outcomes associated with SUV39H1-related inflammation were also studied. The relationships between SUV39H1 and neutrophil or eosinophil (Th2 response) counts and clinical outcomes were evaluated. In an extended COPD cohort (213 patients), association analyses of blood cell counts with comorbidities and exacerbations were performed.RESULTS: Low SUV39H1 expression was associated with high neutrophil counts and a trend towards low eosinophil counts. In the extended cohort, the high comorbidity group had higher neutrophil counts than the low comorbidity group but similar whole white blood cell counts. The eosinophil percentage and eosinophil/neutrophil ratio displayed contrasting results. The proportion of neutrophils was correlated with COPD comorbidities. Patients with 0-1 moderate to severe exacerbations in the past year had numbers of neutrophils and eosinophils similar to those of patients who experienced more than an exacerbation. Finally, patients with high comorbidities had lower SUV39H1 levels in their PBMCs than did those with low comorbidities.CONCLUSION: Blood neutrophil counts are associated with comorbidities in COPD patients. Impaired SUV39H1 expression in PBMCs from COPD patients are correlated with neutrophilic inflammation and comorbidities.

scholarly journals Effects of doxycycline on local and systemic inflammation in stable COPD patients, a randomized clinical trial

2016 ◽  
Vol 110 ◽  
pp. 46-52 ◽  
Author(s):  
Hendrik J. Prins ◽  
Johannes M.A. Daniels ◽  
Jan H. Lindeman ◽  
René Lutter ◽  
Wim G. Boersma
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Systemic Inflammation ◽  
Copd Patients

Antioxidants in Serum and Induced Sputum of COPD Patients

2001 ◽  
Vol 50 (2) ◽  
pp. 158
Author(s):  
Hyeon Kwan Park ◽  
Young Kwon Yu ◽  
Kyu Sik Kim ◽  
Sung Chul Lim ◽  
Young Chul Kim ◽  
...  
Keyword(s):  
Induced Sputum ◽  
Copd Patients

Systemic Inflammation And Pulmonary Hypertension In COPD Patients

2010 ◽  
Author(s):  
Hong Joon Shin ◽  
Yong Soo Kwon ◽  
Yu Il Kim ◽  
Sung Chul Lim ◽  
Young Chul Kim ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Systemic Inflammation ◽  
Copd Patients

scholarly journals Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anouk W. Vaes ◽  
Martijn A. Spruit ◽  
Karel Van Keer ◽  
João Barbosa-Breda ◽  
Emiel F. M. Wouters ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Lung Function ◽  
Systolic Blood Pressure ◽  
Systemic Inflammation ◽  
Pulmonary Rehabilitation ◽  
Functional Outcomes ◽  
Retinal Vessel ◽  
Copd Patients ◽  
Retinal Vessel Diameters

AbstractCardiovascular diseases are frequently present in chronic obstructive pulmonary disease (COPD). Population-based studies found associations between retinal vessel diameters and cardiovascular health, but it is unknown whether this also applies to COPD patients. Therefore, we measured retinal vessel diameters in COPD patients and aimed to determine the association with cardiovascular risk factors, lung function, and functional outcomes. In addition, we investigated whether an exercise-based pulmonary rehabilitation (PR) program would change retinal vessel diameters, as a proxy for improved microvascular health. Demographics and clinical characteristics, including pulmonary function, exercise capacity, blood pressure, blood measurements and level of systemic inflammation were obtained from 246 patients during routine assessment before and after PR. Retinal vessel diameters were measured from digital retinal images. Older age and higher systolic blood pressure were associated with narrower retinal arterioles (β: −0.224; p = 0.042 and β: −0.136; p < 0.001, respectively). Older age, higher systolic blood pressure and lower level of systemic inflammation were associated with narrower retinal venules (β: −0.654; −0.229; and −13.767, respectively; p < 0.05). No associations were found between retinal vessel diameters and lung function parameters or functional outcomes. After PR, no significant changes in retinal venular or arteriolar diameter were found. To conclude, retinal vessel diameters of COPD patients were significantly associated with systolic blood pressure and systemic inflammation, whilst there was no evidence for an association with lung function parameters, functional outcomes or other cardiovascular risk factors. Furthermore, an exercise-based PR program did not affect retinal vessel diameter.

scholarly journals Lymphocytes Apoptosis in Patients with Acute Exacerbation of Asthma

1999 ◽  
Vol 8 (4-5) ◽  
pp. 237-243 ◽  
Author(s):  
Agnès Hamzaoui ◽  
Kamel Hamzaoui ◽  
Habib Salah ◽  
Abdellatif Chabbou
Keyword(s):  
Acute Exacerbation ◽  
Mononuclear Cells ◽  
Allergic Inflammation ◽  
Induced Sputum ◽  
Chronic Obstructive ◽  
Complex Method ◽  
Healthy Controls ◽  
Asthmatic Patients ◽  
Copd Patients ◽  
Tnf Α

Asthma is characterized by airway inflammation, which can be now assessed by the analysis of induced sputum . Ten patients with asthma were investigated during acute exacerbation for the quantification of apoptosis, for Bcl-2 and Fas expression, in induced sputum lymphocytes. They were compared to 12 patients with chronic obstructive pulmonary disease (COPD), and 10 healthy controls. Spontaneous apoptosis was determined by staining nuclei with propidium iodide, and analyzed with a FACScan. Bcl-2 was measured by Western blotting, and results were obtained by densitometric scanning, done by the gel proanalyser. The investigation of Fas was performed using the streptavidin-biotin preroxidase-complex method. Patients with asthma and patients with COPD exhibited a significant increase of cellularity, percentage of neutrophils, eosinophils and lymphocytes when compared to healthy controls. Apoptosis in induced sputum mononuclear cells was found decreased in patients with asthma compared to COPD patients and healthy controls. The quantification of apoptosis was measured after exposure to anticytokine antibodies. Anti-TNF-α antibody blocked the apoptosis in both patients groups and healthy controls, suggesting that TNF-α acted as an inducer of apoptosis. Anti-IL-10 blocked apoptosis completely exclusively in patients with asthma. Bcl-2 expression was found to be increased in induced sputum mononuclear cells from patients with asthma, compared to healthy controls and patients with COPD. Expression of Fas could be detected in patients with asthma, at a lower level than COPD patients and healthy controls. Distinct mechanisms of apoptosis were found in patients with asthma and patients with COPD, characterized by different levels of Bcl-2 and Fas expression. Induction of apoptosis should be a beneficial process in allergic inflammation traduced in induced sputum mononuclear cells. The apoptosis process is assumed by two different mechanisms in asthma and COPD. Our findings indicated that in asthmatic patients, activated lymphocytes accumulate in the bronchi; because of their prolonged survival that maintains inflammation.

scholarly journals Elevated levels of circulating exosome in COPD patients are associated with systemic inflammation

2017 ◽  
Vol 132 ◽  
pp. 261-264 ◽  
Author(s):  
Dino B.A. Tan ◽  
Jesse Armitage ◽  
Teck-Hui Teo ◽  
Nathanael E. Ong ◽  
Heewoong Shin ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Copd Patients
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