scholarly journals Comparison of the peripheral blood eosinophil count using near-patient testing and standard automated laboratory measurement in healthy, asthmatic and COPD subjects

2017 ◽  
Vol Volume 12 ◽  
pp. 2771-2775 ◽  
Author(s):  
Kirsty Hambleton ◽  
Clare Connolly ◽  
Catherine Borg ◽  
Joanne Davies ◽  
Helen Jeffers ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Eosinophil Count ◽  
Laboratory Measurement ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Blood Eosinophil Count ◽  
Near Patient Testing

Evaluation of the peripheral blood eosinophil count as a predictor for fractional exhaled nitric oxide or bronchodilator reversibility test outcome

2021 ◽  
Vol 42 (3) ◽  
pp. 228-234
Author(s):  
Bo Zhao ◽  
Haiming Zheng ◽  
Xiaopan Li ◽  
Rui Zheng
Keyword(s):  
Nitric Oxide ◽  
Roc Curve ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Test Results ◽  
Fractional Exhaled Nitric Oxide ◽  
Peripheral Blood Eosinophil ◽  
Blood Eosinophil Count ◽  
Feno Level

Objective: This study aimed to explore the usefulness of the peripheral blood eosinophil count (PBEC) in assessing the level of fractional exhaled nitric oxide (FeNO) and predicting bronchodilation test results. Methods: We retrospectively analyzed the data of 384 outpatients who underwent FeNO measurement at our Department of Respiratory and Critical Care Medicine from March to June 2019. The FeNO level was compared among different PBECs to explore the association among them. Furthermore, the sensitivity and specificity of PBECs in predicting bronchodilation test results were assessed by using receiver operating characteristic (ROC) curve analysis. Results: There was a moderate correlation between PBECs and FeNO levels (r = 0.414; p < 0.05). In the subjects with PBECs ≥ 0.3 × 109/L, the median FeNO level was 39 ppb (interquartile range, 22.5‐65.5 ppb), significantly higher than in the subjects with PBECs < 0.3 × 109/L. The area under the ROC curve was 0.707 (p < 0.05). The maximum Youden index (0.348) was at PBECs = 0.205 × 109/L, which achieved sensitivity and specificity of 63% and 71.8%, respectively. Conclusion: PBECs ≥ 0.3 × 109/L can predict a positive bronchodilation test result and a high FeNO level, with a probability of 50% in the subjects with chronic cough and shortness of breath; in the absence of corresponding symptoms and a low PBEC, the predictive value was small. For hospitals not able to conduct FeNO measurements, for outpatients with poor economic conditions, and for patients with confirmed or suspected novel coronavirus disease 2019, the PBEC, in conjunction with a patient's clinical symptoms, can improve the diagnostic accuracy of allergic asthma and assessment of airway inflammation while reducing the risk of infection.

Peripheral blood eosinophil count correlates with survival in lung cancer

Lung Cancer ◽  
2010 ◽  
Vol 67 ◽  
pp. S40-S41 ◽  
Author(s):  
A. Shelton ◽  
R.H. Green ◽  
P. Bradding ◽  
C.M. Free
Keyword(s):  
Lung Cancer ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Blood Eosinophil Count

scholarly journals Prognostic value of peripheral blood eosinophil count on first day of infancy in the incidence of neonatal hyperbilirubinemia

2018 ◽  
Vol 4 (5) ◽  
pp. 99
Author(s):  
Adel Ahadi ◽  
Mehrdad Mirzarahimi ◽  
Saeid Alaei ◽  
Farzad Ahmadabadi
Keyword(s):  
Gestational Age ◽  
Significant Relationship ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Prognostic Value ◽  
Serum Bilirubin ◽  
Total Serum ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Blood Eosinophil Count

<p class="abstract"><strong>Background:</strong> Neonatal jaundice is one of the most common problems in the neonatal period. Eosinophilia is common in preterm and term newborns, and it is considered when the absolute count of eosinophil is ≥500 cell/mm<sup>3</sup>. It is thought that there was some relationship between hyperbilirubinemia and increasing of blood eosinophil count in newborns hospitalized by jaundice. The aim of this study was to determine the prognostic value of peripheral blood eosinophil count on first day of infancy in the incidence of neonatal hyperbilirubinemia.</p><p class="abstract"><strong>Methods:</strong> 150 newborns with gestational ages of 35-40 weeks, born in Ardabil city hospital, were engaged in this study. After obtaining the parents' consent, getting patients biography and their physical examination, we got a blood sample from umbilical cord of newborns to measure differential count of white blood cells. The neonates were observed up to 28 day followed. Then, second blood test conducted for the purpose of measuring serum level of bilirubin. Data were analyzed by statistical methods in SPSS version 19.  </p><p class="abstract"><strong>Results:</strong> Various group of age, sex, blood type and gestational age showed no significant difference in their eosinophil rate. Total serum bilirubin doesn't had a significant relationship with gestational age, sex, type of delivery and major or minor blood groups of neonates.</p><p class="abstract"><strong>Conclusions:</strong> Results showed that there was no significant relationship between the amount of eosinophil in newborn umbilical cord and total serum bilirubin. So, we could say that newborns eosinophil count isn’t a good criteria for predicating the appearance of neonate hyperbilirubinemia.</p>

Peripheral Blood Eosinophil Count as a Marker of Pulmonary Allograft Rejection

2019 ◽  
Vol 38 (4) ◽  
pp. S403-S404
Author(s):  
S. Aguado Ibáñez ◽  
J. Carrillo ◽  
M. Aguilar ◽  
R. Laporta ◽  
C. López ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Allograft Rejection ◽  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Blood Eosinophil Count

scholarly journals Peripheral blood eosinophil count is associated with response to chemoimmunotherapy in metastatic triple-negative breast cancer

Immunotherapy ◽  
2022 ◽  
Author(s):  
Hazem Ghebeh ◽  
Mahmoud A Elshenawy ◽  
Adher D AlSayed ◽  
Taher Al-Tweigeri
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Triple Negative ◽  
Statistical Significance ◽  
Progression Free Survival ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Blood Eosinophil Count

Introduction: There is evidence for an association between peripheral blood eosinophil count (PBEC) and response to cancer immunotherapy; however, such data is limited in metastatic triple-negative breast cancer (mTNBC). Patients & methods: This report presents patients (n = 14) who received a combination of durvalumab and paclitaxel for mTNBC (NCT02628132). Results: There was a statistically significant correlation (p = 0.028) between an increase in PBEC (>300/mm3) during treatment and response to the combination therapy. Survival analysis showed a statistically significant association between progression-free survival and increased PBEC, after therapy (p = 0.005). A similar trend existed for overall survival, although it did not reach statistical significance (p = 0.167). Conclusion: This is the first study to report on eosinophilia in mTNBC treated with chemoimmunotherapy and supports a role for eosinophils in immunotherapy for mTNBC.

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