scholarly journals Real-world impact of education: treating patients with ipilimumab in a community practice setting

2013 ◽  
pp. 5 ◽  
Author(s):  
Blanca Ledezma ◽  
Annie Heng
Keyword(s):  
Real World ◽  
Practice Setting ◽  
Community Practice

scholarly journals A Real-World Observational Study of Patients with Advanced Melanoma Receiving First-Line Ipilimumab in a Community Practice Setting

2014 ◽  
Vol 05 (12) ◽  
pp. 1049-1058 ◽  
Author(s):  
Debra A. Patt ◽  
Debra Rembert ◽  
Menaka Bhor ◽  
Debajyoti Bhowmik ◽  
Sumati A. Rao
Keyword(s):  
Observational Study ◽  
Real World ◽  
Advanced Melanoma ◽  
Practice Setting ◽  
Community Practice ◽  
First Line

scholarly journals Transdisciplinary Translational Science for Youth Health and Wellness: Introduction to a Special Issue

2021 ◽  
Author(s):  
Ashley T. Scudder ◽  
Gregory J. Welk ◽  
Richard Spoth ◽  
Constance C. Beecher ◽  
Michael C. Dorneich ◽  
...  
Keyword(s):  
Real World ◽  
Social Needs ◽  
Research Network ◽  
World Health ◽  
Translational Science ◽  
Community Practice ◽  
Health And Wellness ◽  
Youth Health ◽  
Special Issue ◽  
Interdisciplinary Approaches

Abstract Background Transdisciplinary translational science applies interdisciplinary approaches to the generation of novel concepts, theories and methods involving collaborations among academic and non-academic partners, in order to advance the translation of science into broader community practice. Objective This paper introduces a special issue on transdisciplinary translational science for youth health and wellness. We provide an overview of relevant research paradigms, share the related goals of the Iowa State University Translational Research Network (U-TuRN), and introduce the specific papers in the issue. Method Authors were asked to submit empirical reports, programmatic reviews or policy-related papers that examined youth health issues from a transdisciplinary translational perspective. Results The papers included in this special issue each involve direct and fully-integrated community-university partnerships and collaborations between academic and non-academic partners in scholarship and research. Reports emphasize the value of the applied nature of the work with a research agenda driven primarily by real-world health and social needs. Conclusions There is growing acceptance of the need for transdisciplinary, community-university collaborative research approaches as a means to meet both the requirements posed by real-world problems as well as goals of advancing scientific knowledge and innovation. In this issue, readers will find papers that show the promise of rethinking existing conceptual frameworks to incorporate transdisciplinary approaches as a catalyst to addressing translational science questions related to the field of children and youth care.

Cetuximab Plus Irinotecan in Heavily Pretreated Metastatic Colorectal Cancer Progressing on Irinotecan: MABEL Study

2008 ◽  
Vol 26 (33) ◽  
pp. 5335-5343 ◽  
Author(s):  
Hansjochen Wilke ◽  
Robert Glynne-Jones ◽  
Josef Thaler ◽  
Antoine Adenis ◽  
Peter Preusser ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Progression Free Survival ◽  
Primary Objective ◽  
Practice Setting ◽  
Community Practice ◽  
Efficacy And Safety ◽  
Intention To Treat ◽  
Heavily Pretreated ◽  
N 93

Purpose This large, multinational study aimed to confirm in a community practice setting the efficacy and safety of cetuximab plus irinotecan in patients with epidermal growth factor–expressing metastatic colorectal cancer (mCRC) who had recently failed an irinotecan-containing regimen. Patients and Methods The primary objective was to determine the progression-free survival (PFS) rate at 12 weeks. The initial cetuximab dose was 400 mg/m2 and was followed weekly by 250 mg/m2; irinotecan (according to prestudy regimen) was given weekly (125 mg/m2 weekly for 4 of 6 weeks), every 2 weeks (180 mg/m2 each), or every 3 weeks (350 mg/m2 each). Results The intention-to-treat/safety population comprised 1,147 treated patients who received irinotecan weekly (n = 93); every 2 weeks (n = 670); every 3 weeks (n = 356); or another dose (n = 28). The PFS rate at 12 weeks was 61%, and the median survival was 9.2 months. Treatment was generally well tolerated. The most common treatment-related grades 3 to 4 adverse events were diarrhea (19%), neutropenia (10%), rash (7%), and asthenia (6%). The rate of grades 3 to 4 infusion-related reactions (IRRs; composite adverse event category) was 1% for patients who received both antihistamine and corticosteroid premedication. Conclusion Tolerability (except IRR incidence), PFS rate, and overall survival rate were in line with previous results. At 1%, the rate of IRRs in patients who received prophylactic premedication with both antihistamine and corticosteroid is lower than previously reported. MABEL clearly confirms in a community practice setting the efficacy and safety of cetuximab plus irinotecan in the treatment of mCRC.

A Model for Training Pediatricians to Expand Mental Health Services in the Community Practice Setting

2006 ◽  
Vol 45 (7) ◽  
pp. 649-654 ◽  
Author(s):  
Marlene Goodfriend ◽  
Thomas Bryant ◽  
William Livingood ◽  
Jeffrey Goldhagen
Keyword(s):  
Mental Health ◽  
Mental Health Services ◽  
Health Services ◽  
Practice Setting ◽  
Community Practice

Hereditary Cancer Risk Assessment and Genetic Testing in the Community-Practice Setting

2018 ◽  
Vol 132 (5) ◽  
pp. 1121-1129 ◽  
Author(s):  
Mark S. DeFrancesco ◽  
Richard N. Waldman ◽  
Melissa M. Pearlstone ◽  
Dana Karanik ◽  
Ryan Bernhisel ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Genetic Testing ◽  
Cancer Risk ◽  
Hereditary Cancer ◽  
Cancer Risk Assessment ◽  
Practice Setting ◽  
Community Practice
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