scholarly journals The association of race with timeliness of care and survival among Veterans Affairs health care system patients with late-stage non-small cell lung cancer

2013 ◽  
pp. 157 ◽  
Author(s):  
Leah Zullig ◽  
Carpenter ◽  
Provenzale ◽  
Morris Weinberger ◽  
Reeve ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Health Care ◽  
Small Cell Lung Cancer ◽  
Health Care System ◽  
Cell Lung Cancer ◽  
Late Stage ◽  
Veterans Affairs ◽  
Small Cell ◽  
Small Cell Lung ◽  
Care System

scholarly journals Survival and Toxicity After Cisplatin Plus Etoposide Versus Carboplatin Plus Etoposide for Extensive-Stage Small-Cell Lung Cancer in Elderly Patients

2016 ◽  
Vol 12 (7) ◽  
pp. 666-673 ◽  
Author(s):  
Laura A. Hatfield ◽  
Haiden A. Huskamp ◽  
Elizabeth B. Lamont
Keyword(s):  
Lung Cancer ◽  
Health Care ◽  
Elderly Patients ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Odds Ratio ◽  
Small Cell ◽  
Small Cell Lung ◽  
First Line ◽  
Extensive Stage

Purpose: Elderly patients with cancer are under-represented in clinical trials and risk greater toxicity from chemotherapy. These patients and their physicians need better evidence to decide among guideline-recommended regimens. We test whether patients with extensive-stage small-cell lung cancer (ES SCLC) have noninferior survival and less hospital-based health care after carboplatin/etoposide compared with cisplatin/etoposide. Methods: We analyzed SEER-Medicare data for beneficiaries with ES SCLC diagnosed at age 67 years and older between 1995 and 2009. Among patients treated with first-line chemotherapy in the ambulatory setting, 831 received cisplatin/etoposide and 2,846 received carboplatin/etoposide. Propensity score matching (2:1 ratio) yielded 778 cisplatin/etoposide and 1,502 carboplatin/etoposide patients. Results: Survival was nearly identical in the two groups: 35.7 weeks for cisplatin/etoposide and 35.9 weeks for carboplatin/etoposide. The hazard ratio of 1 (95% CI, 0.91 to 1.09) excluded our prespecified threshold, indicating noninferiority. Mortality at 6 months was indistinguishable: 35% for cisplatin/etoposide and 34% for carboplatin/etoposide. After carboplatin/etoposide, patients were less likely to be admitted to a hospital (80% v 86%, P < .001) and had fewer hospitalizations (median 1 v 2, odds ratio 0.76, 95% CI, 0.65 to 0.9), ED visits (median 1 v 2, odds ratio 0.82, 95% CI, 0.7 to 0.96), and ICU stays (median 0 v 0, odds ratio 0.82, 95% CI, 0.69 to 0.99). Conclusion: First-line carboplatin/etoposide is associated with similar survival and less subsequent hospital-based health care use than cisplatin/etoposide among elderly patients with ES SCLC treated in ambulatory settings.

scholarly journals Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer

Autophagy ◽  
2018 ◽  
Vol 15 (3) ◽  
pp. 391-406 ◽  
Author(s):  
Lu Zhang ◽  
PengFei Qiang ◽  
JingTing Yu ◽  
YiMing Miao ◽  
ZhiQiang Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Late Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Autophagy Inhibitor
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