scholarly journals Comparison of Different EGFR Gene Mutation Status in Patients with Metastatic Non-Small Lung Cancer After First-Line EGFR-TKIs Therapy and Analyzing Its Relationship with Efficacy and Prognosis

2021 ◽  
Vol Volume 13 ◽  
pp. 6901-6910
Author(s):  
Chengliang Yuan ◽  
Huiqin Jiang ◽  
Wei Jiang ◽  
Huilin Wang ◽  
Cuiyun Su ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Mutation ◽  
First Line ◽  
Mutation Status ◽  
Egfr Gene ◽  
Egfr Tkis ◽  
Egfr Gene Mutation

Assessing EGFR gene mutation status in non-small cell lung cancer with imaging features from PET/CT

2019 ◽  
Vol 40 (8) ◽  
pp. 842-849 ◽  
Author(s):  
Mengmeng Jiang ◽  
Yiqian Zhang ◽  
Junshen Xu ◽  
Min Ji ◽  
Yinglong Guo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Gene Mutation ◽  
Small Cell ◽  
Imaging Features ◽  
Small Cell Lung ◽  
Mutation Status ◽  
Egfr Gene ◽  
Pet Ct ◽  
Egfr Gene Mutation

scholarly journals Clinicopathologic Features and Molecular Biomarkers as Predictors of Epidermal Growth Factor Receptor Gene Mutation in Non-Small Cell Lung Cancer Patients

2021 ◽  
Vol 29 (1) ◽  
pp. 77-93
Author(s):  
Lanlan Liu ◽  
Xianzhi Xiong
Keyword(s):  
Lung Cancer ◽  
Gene Mutation ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Small Cell Lung ◽  
Mutation Status ◽  
Egfr Gene ◽  
Epidermal Growth ◽  
Nsclc Patients ◽  
Egfr Gene Mutation

Lung cancer ranks first in the incidence and mortality of cancer in the world, of which more than 80% are non-small cell lung cancer (NSCLC). The majority of NSCLC patients are in stage IIIB~IV when they are admitted to hospital and have no opportunity for surgery. Compared with traditional chemotherapy, specific targeted therapy has a higher selectivity and fewer adverse reactions, providing a new treatment direction for advanced NSCLC patients. Tyrosine kinase inhibitors of epidermal growth factor receptor (EGFR-TKIs) are the widely used targeted therapy for NSCLC patients. Their efficacy and prognosis are closely related to the mutation status of the EGFR gene. Clinically, detecting EGFR gene mutation is often limited by difficulty obtaining tissue specimens, limited detecting technology, and economic conditions, so it is of great clinical significance to find indicators to predict EGFR gene mutation status. Clinicopathological characteristics, tumor markers, liquid biopsy, and other predictors are less invasive, economical, and easier to obtain. They can be monitored in real-time, which is supposed to predict EGFR mutation status and provide guidance for the accurate, individualized diagnosis and therapy of NSCLC patients. This article reviewed the correlation between the clinical indicators and EGFR gene mutation status in NSCLC patients.

Detection of EGFR Gene Mutation in Lung Cancer by Mutant-Enriched Polymerase Chain Reaction Assay

2006 ◽  
Vol 12 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Hiroaki Asano ◽  
Shinichi Toyooka ◽  
Masaki Tokumo ◽  
Kouichi Ichimura ◽  
Keisuke Aoe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Polymerase Chain Reaction ◽  
Gene Mutation ◽  
Polymerase Chain Reaction Assay ◽  
Chain Reaction ◽  
Egfr Gene ◽  
Polymerase Chain ◽  
Egfr Gene Mutation

scholarly journals The efficacy of EGFR gene mutation testing in various samples from non-small cell lung cancer patients: a multicenter retrospective study

2014 ◽  
Vol 141 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Paweł Krawczyk ◽  
Rodryg Ramlau ◽  
Joanna Chorostowska-Wynimko ◽  
Tomasz Powrózek ◽  
Marzena Anna Lewandowska ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Retrospective Study ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Gene Mutation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Egfr Gene ◽  
Lung Cancer Patients ◽  
Egfr Gene Mutation

scholarly journals Clinicopathologic Characteristics of the EGFR Gene Mutation in Non–small Cell Lung Cancer

2006 ◽  
Vol 1 (3) ◽  
pp. 231-239 ◽  
Author(s):  
Anne S. Tsao ◽  
Xi Ming Tang ◽  
Bradley Sabloff ◽  
Lianchun Xiao ◽  
Hisayuki Shigematsu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Gene Mutation ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Clinicopathologic Characteristics ◽  
Egfr Gene ◽  
Egfr Gene Mutation
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