scholarly journals Multiple Pulmonary Metastases of Recurrent Giant Cell Tumor of Bone with Expression of VEGFR-2 Successfully Controlled by Denosumab and Apatinib: A Case Report and Literature Review

2021 ◽  
Vol Volume 13 ◽  
pp. 4447-4454
Author(s):  
Taojun Gong ◽  
Yi Luo ◽  
Yitian Wang ◽  
Chuanxi Zheng ◽  
Jianguo Fang ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Pulmonary Metastases ◽  
Cell Tumor ◽  
Recurrent Giant Cell Tumor

scholarly journals Denosumab treatment for progressive skull base giant cell tumor of bone in a 14 year old female – a case report and literature review

2017 ◽  
Vol 43 (1) ◽  
Author(s):  
Samvel Bardakhchyan ◽  
Leo Kager ◽  
Samvel Danielyan ◽  
Armen Avagyan ◽  
Nerses Karamyan ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Skull Base ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Denosumab Treatment

scholarly journals Hemorrhagic Giant Cell Tumor of the Occipital Skull Base: A Case Report and Literature Review

Cureus ◽  
2021 ◽  
Author(s):  
Cihan Kadipasaoglu ◽  
Andrew Wahba ◽  
Meenakshi B Bhattacharjee ◽  
Branko Cuglievan ◽  
Stephen A Fletcher
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Skull Base ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor

scholarly journals Multiple Pulmonary Metastases of Giant Cell Tumor of Bone with expression of VEGFR-2 Successfully Treated by Denosumab and Apatinib: A Rare Case Report

2021 ◽  
Author(s):  
taojun gong ◽  
Yi Luo ◽  
Yitian Wang ◽  
Chuanxi Zheng ◽  
Jianguo Fang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Local Recurrence ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Pulmonary Metastases ◽  
Cell Tumor ◽  
Wide Resection ◽  
High Tendency ◽  
Bony Destruction

Abstract Background: Giant cell tumor of bone (GCTB) is a rare benign but locally aggressive bone tumor. It has a high tendency for local recurrence, which may increase the occurrence of lung metastasis. Currently, the treatment of pulmonary metastases of GCTB is controversial. Denosumab is the preferred regimen for unresectable metastatic lesions, but there are no alternative treatment options when denosumab is resistant. So far, no case reports of metastatic GCTB treated with denosumab and apatinib have been published. Case presentation: This is a case report of a 26-year-old female who experienced right knee pain for over 6 months. Radiography and computed tomography revealed osteolytic bony destruction in the proximal right tibia. Using histological, radiological, and clinical techniques, a diagnosis of GCTB was achieved. Meanwhile, the immunohistochemical stain-identified the tumor cells were positive for vascular endothelial growth factor receptor 2 (VEGFR-2). After intralesional curettage of the primary tumor and wide resection of local recurrence surgeries, she developed recurrent hemoptysis. Chest computed tomography (CT) images showed multiple pulmonary nodules. She was administrated denosumab therapy but disease progression was confirmed after four months of treatment. She then received denosumab and apatinib therapy for 24 months, after a partial response was achieved.Conclusions: We depict a case of multiple pulmonary metastases of GCTB successfully controlled by denosumab and apatinib therapy. VEGFR-2 may be an effective therapeutic target for GCTB with pulmonary metastasis when denosumab is ineffective.

A thoracic spinal bone giant cell tumor in a skeletally immature girl. A case report and literature review

2016 ◽  
Vol 32 (5) ◽  
pp. 873-876 ◽  
Author(s):  
Loic Sigwalt ◽  
Emeline Bourgeois ◽  
Ahmad Eid ◽  
Chantal Durand ◽  
Jacques Griffet ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Skeletally Immature ◽  
Thoracic Spinal

Sphenoid bone: a rare site for giant cell tumor – case report with literature review

2016 ◽  
Vol 35 (11) ◽  
pp. 385-388 ◽  
Author(s):  
Debajyoti Chatterjee ◽  
Kirti Gupta ◽  
Navneet Singla ◽  
Ankur Kapoor
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Sphenoid Bone ◽  
Rare Site
Sign in / Sign up

Export Citation Format

Share Document