scholarly journals Diagnostic Value of Serum lncRNA HOTAIR Combined with Galectin-3 in Benign and Papillary Thyroid Carcinoma

2021 ◽  
Vol Volume 13 ◽  
pp. 6517-6525
Author(s):  
Li Li ◽  
Jianjun Wang ◽  
Zhongquan Li ◽  
Shuang Qiu ◽  
Junyu Cao ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Diagnostic Value ◽  
Papillary Thyroid ◽  
Galectin 3 ◽  
Lncrna Hotair

scholarly journals Serum Galectin-3: diagnostic value for papillary thyroid carcinoma

2015 ◽  
Vol 31 (4) ◽  
pp. 192-196 ◽  
Author(s):  
Erdem Yilmaz ◽  
Tamer Karsidag ◽  
Cihad Tatar ◽  
Sefa Tuzun
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Diagnostic Value ◽  
Papillary Thyroid ◽  
Galectin 3

scholarly journals Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions

Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1246
Author(s):  
Hao-Wen Chuang ◽  
Jyh-Seng Wang ◽  
Jen-Wei Tsai ◽  
Chao-Tien Hsu ◽  
Kai-Jen Lin
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
High Specificity ◽  
Thyroid Neoplasms ◽  
Diagnostic Value ◽  
Papillary Thyroid ◽  
Close Relationship ◽  
Galectin 3 ◽  
Nuclear Features ◽  
Ihc Markers

Background and Objectives: We aimed to assess the diagnostic value of various immunohistochemical (IHC) markers and panels for differentiation among benign follicular nodules (BFNs), noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs), noninvasive encapsulated follicular variants of papillary thyroid carcinoma (NEFVPTCs), and infiltrative FVPTC (IFVPTC). Materials and Methods: Sixty-three cases were classified as BFNs, NIFTPs, NEFVPTCs, or IFVPTCs and were evaluated using the following markers: CK19, CD56, galectin-3, CITED1, HBME-1, VE1, and TROP-2. Results: The IHC results for NIFTP and NEFVPTC exhibited no statistically significant differences. In differentiating IFVPTCs from BFNs and NIFTPs/NEFVPTCs, galectin-3 and TROP-2 were the markers with the highest sensitivity plus high specificity, respectively. In various combinations, panel co-expression of two markers, including galectin-3 and/or HBME-1 and/or TROP-2, and the combination of galectin-3 and TROP-2 co-expression could achieve 100% in all aspects. In terms of discrimination of BFNs from NIFTP/NEFVPTC, CK19 was the single most sensitive marker (81.3%), while CD56 was the most specific (100%). The panel consisting of CK19 and/or HBME-1 exhibited the greatest sensitivity (96.9%), but the panel with CD56 and/or HBME-1 exhibited the greatest specificity (90.5%). Conclusions: Our results broaden the use of IHC markers for differential diagnoses among the four groups of follicular-based lesions. In addition, the similar IHC profiles of NIFTP and NEFVPTC also suggest the original criterion of <1% papillae within tumors, providing a reliable NIFTP diagnosis. Their close relationship may represent a spectrum of progressing neoplasia.

Diagnostic Value of Immunohistochemistry for the Detection of the BRAFV600E Mutation in Papillary Thyroid Carcinoma: Comparative Analysis with Three DNA-Based Assays

Thyroid ◽  
2014 ◽  
Vol 24 (5) ◽  
pp. 858-866 ◽  
Author(s):  
Marius I. Ilie ◽  
Sandra Lassalle ◽  
Elodie Long-Mira ◽  
Christelle Bonnetaud ◽  
Olivier Bordone ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Diagnostic Value ◽  
Papillary Thyroid ◽  
Brafv600e Mutation
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