scholarly journals Polysaccharide-Based Lotus Seedpod Surface-Like Porous Microsphere as an Efficient Drug Carrier for Cancer Treatment

2021 ◽  
Vol Volume 13 ◽  
pp. 4067-4076
Author(s):  
Yuanbo Wu ◽  
Jiandong Zhang ◽  
Jiangwei Ni ◽  
Zhihao Yang ◽  
Kun Chen ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Drug Carrier ◽  
Porous Microsphere ◽  
Lotus Seedpod

Controlled release of KGF-2 for regulation of wound healing by KGF-2 complexed with “lotus seedpod surface-like” porous microsphere

2021 ◽  
Author(s):  
Hao Pan ◽  
Changcan Shi ◽  
Rongshuai Yang ◽  
Guanghui Xi ◽  
Chao Lu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Controlled Release ◽  
Growth Factor ◽  
Normal Tissue ◽  
Keratinocyte Growth Factor ◽  
Tissue Structure ◽  
Effective Strategy ◽  
Proliferation And Differentiation ◽  
Porous Microsphere ◽  
Lotus Seedpod

Keratinocyte growth factor-2 (KGF-2) plays a remarkable role in maintaining normal tissue structure and promoting wound healing by regulation the proliferation and differentiation of keratinocyte. As an effective strategy, KGF-2...

Polysaccharide-Based Lotus Seedpod Surface-Like Porous Microsphere with Precise and Controllable Micromorphology for Ultrarapid Hemostasis

2019 ◽  
Vol 11 (50) ◽  
pp. 46558-46571 ◽  
Author(s):  
Guanghui Xi ◽  
Wen Liu ◽  
Miao Chen ◽  
Qian Li ◽  
Xiao Hao ◽  
...  
Keyword(s):  
Porous Microsphere ◽  
Lotus Seedpod

T lymphocytes as potential therapeutic drug carrier for cancer treatment

2006 ◽  
Vol 311 (1-2) ◽  
pp. 229-236 ◽  
Author(s):  
Ute Steinfeld ◽  
Christine Pauli ◽  
Nikolas Kaltz ◽  
Christian Bergemann ◽  
Hyeck-Hee Lee
Keyword(s):  
T Lymphocytes ◽  
Cancer Treatment ◽  
Drug Carrier ◽  
Therapeutic Drug

scholarly journals NIR Light-Triggered Chemo-Phototherapy by ICG Functionalized MWNTs for Synergistic Tumor-Targeted Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2145
Author(s):  
Lu Tang ◽  
Aining Zhang ◽  
Yijun Mei ◽  
Qiaqia Xiao ◽  
Xiangting Xu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Drug Carrier ◽  
Tumor Growth Inhibition ◽  
In Vivo Experiments ◽  
Promising Application ◽  
Targeting Ability

The combinational application of photothermal therapy (PTT), chemotherapy, and nanotechnology is a booming therapeutic strategy for cancer treatment. Multi-walled carbon nanotube (MWNT) is often utilized as drug carrier in biomedical fields with excellent photothermal properties, and indocyanine green (ICG) is a near-infrared (NIR) dye approved by FDA. In addition, ICG is also a photothermal agent that can strongly absorb light energy for tumor ablation. Herein, we explored a synergistic strategy by connecting MWNT and a kind of ICG derivate ICG-NH2 through hyaluronic acid (HA) that possesses CD44 receptor targeting ability, which largely enhanced the PTT effect of both MWNT and ICG-NH2. To realize the synergistic therapeutic effect of chemotherapy and phototherapy, doxorubicin (DOX) was attached on the wall of MWNT via π–π interaction to obtain the final MWNT-HA-ICG/DOX nanocomplexes. Both in vitro and in vivo experiments verified the great therapeutic efficacy of MWNT-HA-ICG/DOX nanocomplexes, which was characterized by improved photothermal performance, strengthened cytotoxicity, and elevated tumor growth inhibition based on MCF-7 tumor models. Therefore, this synergistic strategy we report here might offer a new idea with promising application prospect for cancer treatment.

scholarly journals Galactosamine-Conjugating Zwitterionic Block Copolymer for Reduction-Responsive Release and Active Targeted Delivery of Doxorubicin to Hepatic Carcinoma Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Jingming Zhai ◽  
Biyu Zhou ◽  
Yanhui An ◽  
Binzhong Lu ◽  
Yonggang Fan ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Targeted Delivery ◽  
Polymeric Micelles ◽  
Specific Binding ◽  
Drug Carrier ◽  
Polymeric Micelle ◽  
Carcinoma Cells ◽  
Active Targeting ◽  
Hepatic Carcinoma

Nanocarriers with integrated advantage, such as excellent stealth property, active targeting function, and rapid intracellular drug release, are significant for cancer treatment. Herein, a biodegradable zwitterionic triblock copolymer containing disulfide-linked poly-ε-caprolactone and polycarboxybetaine methacrylate (PCB-SS-PCL-SS-PCB) was first synthesized and then partly modified with galactosamine (GAL) for constructing polymeric micelle drug carrier with multifunctionality. Polymeric micelles showed ultralow protein absorption in serum and obvious reduction-responsiveness in the presence of glutathione, provided by the zwitterionic polymer shell and the disulfide bond, respectively. Furthermore, active targeting of the carrier to hepatic carcinoma cells was achieved via GAL ligands on PCB shells due to their specific binding to asialoglycoprotein receptors on the cell surface. As expected, in vivo competition studies demonstrated that doxorubicin- (DOX-) loaded GAL-modified micelles have better anticancer effect in hepatic tumor-bearing mice than free DOX and nontargetable micelles. As a result, this novel multifunctional carrier provides a valuable strategy to design promising anticancer drug delivery systems for liver cancer treatment.

Drug carrier for sustained release of withaferin A for pancreatic cancer treatment

2019 ◽  
Vol 55 (4) ◽  
pp. 1702-1714 ◽  
Author(s):  
Qi Shao ◽  
Yechen Feng ◽  
Wenwu Wang ◽  
Min Wang ◽  
Binbin Li ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Sustained Release ◽  
Cancer Treatment ◽  
Drug Carrier ◽  
Withaferin A

Up-Conversion Y2O3:Yb3+,Er3+ Hollow Spherical Drug Carrier with Improved Degradability for Cancer Treatment

2016 ◽  
Vol 8 (38) ◽  
pp. 25078-25086 ◽  
Author(s):  
Kun Ge ◽  
Cuimiao Zhang ◽  
Wentong Sun ◽  
Huifang Liu ◽  
Yi Jin ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Drug Carrier
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