scholarly journals Prognostic Value of Preoperative Prognostic Nutritional Index and Body Mass Index Combination in Patients with Unresectable Hepatocellular Carcinoma After Transarterial Chemoembolization

2021 ◽  
Vol Volume 13 ◽  
pp. 1637-1650
Author(s):  
Shengwei Li ◽  
Jin-He Guo ◽  
Jian Lu ◽  
Chao Wang ◽  
Hao Wang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Body Mass Index ◽  
Body Mass ◽  
Transarterial Chemoembolization ◽  
Prognostic Value ◽  
Prognostic Nutritional Index ◽  
Nutritional Index ◽  
Unresectable Hepatocellular Carcinoma ◽  
Index Combination

scholarly journals Prognostic value of combined preoperative prognostic nutritional index and body mass index in HCC after hepatectomy

HPB ◽  
2017 ◽  
Vol 19 (8) ◽  
pp. 695-705 ◽  
Author(s):  
Fei Ji ◽  
Yao Liang ◽  
Shunjun Fu ◽  
Dubo Chen ◽  
XiuQin Cai ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Prognostic Value ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

scholarly journals Baseline prognostic nutritional index and changes in pretreatment body mass index associate with immunotherapy response in patients with advanced cancer

2020 ◽  
Vol 8 (2) ◽  
pp. e001674
Author(s):  
Paul Johannet ◽  
Amelia Sawyers ◽  
Yingzhi Qian ◽  
Samuel Kozloff ◽  
Nicholas Gulati ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Nutritional Status ◽  
Body Mass ◽  
Advanced Cancer ◽  
Objective Response ◽  
Prognostic Nutritional Index ◽  
Baseline Body Mass Index ◽  
New York University ◽  
Nutritional Index ◽  
Baseline Bmi

BackgroundRecent research suggests that baseline body mass index (BMI) is associated with response to immunotherapy. In this study, we test the hypothesis that worsening nutritional status prior to the start of immunotherapy, rather than baseline BMI, negatively impacts immunotherapy response.MethodsWe studied 629 patients with advanced cancer who received immune checkpoint blockade at New York University. Patients had melanoma (n=268), lung cancer (n=128) or other primary malignancies (n=233). We tested the association between BMI changes prior to the start of treatment, baseline prognostic nutritional index (PNI), baseline BMI category and multiple clinical end points including best overall response (BOR), objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) and overall survival (OS).ResultsDecreasing pretreatment BMI and low PNI were associated with worse BOR (p=0.04 and p=0.0004), ORR (p=0.01 and p=0.0005), DCR (p=0.01 and p<0.0001), PFS (p=0.02 and p=0.01) and OS (p<0.001 and p<0.001). Baseline BMI category was not significantly associated with any treatment outcomes.ConclusionStandard of care measures of worsening nutritional status more accurately associate with immunotherapy outcomes than static measurements of BMI. Future studies should focus on determining whether optimizing pretreatment nutritional status, a modifiable variable, leads to improvement in immunotherapy response.

scholarly journals Immunonutritive Scoring in Patients With Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: Prognostic Nutritional Index or Controlling Nutritional Status Score?

2021 ◽  
Vol 11 ◽  
Author(s):  
Lukas Müller ◽  
Felix Hahn ◽  
Aline Mähringer-Kunz ◽  
Fabian Stoehr ◽  
Simon J. Gairing ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multivariate Analysis ◽  
Prognostic Factor ◽  
Nutritional Status ◽  
Transarterial Chemoembolization ◽  
Predictive Ability ◽  
Prognostic Nutritional Index ◽  
Independent Prognostic Factor ◽  
Nutritional Index ◽  
Conut Score

ObjectivesThe Prognostic Nutritional Index (PNI) and Controlling Nutritional Status (CONUT) score are immunonutritive scoring systems with proven predictive ability in various cancer entities, including hepatocellular carcinoma (HCC). We performed the first evaluation of the CONUT score for patients undergoing transarterial chemoembolization (TACE) and compared CONUT and PNI in the ability to predict median overall survival (OS).MethodsBetween 2010 and 2020, we retrospectively identified 237 treatment-naïve patients with HCC who underwent initial TACE at our institution. Both scores include the albumin level and total lymphocyte count. The CONUT additionally includes the cholesterol level. Both scores were compared in univariate and multivariate regression analyses taking into account established risk factors. In a second step, a subgroup analysis was performed on BCLC stage B patients, for whom TACE is the recommended first-line treatment.ResultsA high CONUT score and low PNI were associated with impaired median OS (8.7 vs. 22.3 months, p&lt;0.001 and 6.8 vs. 20.1 months, p&lt;0.001, respectively). In multivariate analysis, only the PNI remained an independent prognostic predictor (p=0.003), whereas the CONUT score lost its predictive ability (p=0.201). In the subgroup of recommended TACE candidates, both CONUT and PNI were able to stratify patients according to their median OS (6.6 vs. 17.9 months, p&lt;0.001 and 10.3 vs. 22.0 months, p&lt;0.001, respectively). Again, in the multivariate analysis, only the PNI remained an independent prognostic factor (p=0.012).ConclusionBoth scores were able to stratify patients according to their median OS, but only the PNI remained an independent prognostic factor. Therefore, PNI should be preferred when evaluating the nutritional status of patients undergoing TACE.

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