scholarly journals Development and Validation of Nomograms for Predicting Cancer-Specific Survival in Elderly Patients with Intrahepatic Cholangiocarcinoma After Liver Resection: A Competing Risk Analysis

2020 ◽  
Vol Volume 12 ◽  
pp. 11015-11029
Author(s):  
Tao Wang ◽  
Jinfu Zhang ◽  
Wanxiang Wang ◽  
Xianwei Yang ◽  
Junjie Kong ◽  
...  
Keyword(s):  
Liver Resection ◽  
Risk Analysis ◽  
Elderly Patients ◽  
Intrahepatic Cholangiocarcinoma ◽  
Competing Risk ◽  
Competing Risk Analysis ◽  
Cancer Specific Survival ◽  
Development And Validation

scholarly journals PD51-05 ACTIVE SURVEILLANCE VS. NEPHRON SPARING SURGERY FOR SMALL RENAL MASS IN VERY ELDERLY PATIENTS: A COMPETING RISK ANALYSIS

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Maria Carmen Mir Maresma* ◽  
Michele Marchioni ◽  
Nicola Pavan ◽  
Alessandro Antonelli ◽  
Umberto Capitanio ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Elderly Patients ◽  
Active Surveillance ◽  
Renal Mass ◽  
Nephron Sparing Surgery ◽  
Competing Risk ◽  
Small Renal Mass ◽  
Competing Risk Analysis ◽  
Very Elderly ◽  
Nephron Sparing

scholarly journals Decreasing Postoperative Pulmonary Complication Following Laparoscopic Surgery in Elderly Individuals with Colorectal Cancer: A Competing Risk Analysis in a Propensity Score–Weighted Cohort Study

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 131
Author(s):  
Yih-Jong Chern ◽  
Jeng-Fu You ◽  
Ching-Chung Cheng ◽  
Jing-Rong Jhuang ◽  
Chien-Yuh Yeh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Laparoscopic Surgery ◽  
Risk Analysis ◽  
Elderly Patients ◽  
Open Surgery ◽  
Competing Risk ◽  
Competing Risk Analysis ◽  
Long Term Outcomes ◽  
Laparoscopy Group

Advanced age is a risk factor for major abdominal surgery due to a decline in physical function and increased comorbidities. Although laparoscopic surgery provides good results in most patients with colorectal cancer (CRC), its effect on elderly patients remains unclear. This study aimed to compare the short- and long-term outcomes between open and laparoscopic surgeries in elderly patients with CRC. Total 1350 patients aged ≥75 years who underwent curative resection for stage I–III primary CRC were enrolled retrospectively and were divided into open surgery (846 patients) and laparoscopy (504 patients) groups. After propensity score weighting to balance an uneven distribution, a competing risk analysis was used to analyze the short-term and long-term outcomes. Postoperative mortality rates were lower in the laparoscopy group, especially due to pulmonary complications. Postoperative hospital stay was significantly shorter in the laparoscopy group than in the open surgery group. Overall survival, disease-free survival, and competing risk analysis showed no significant differences between the two groups. Laparoscopic surgery for elderly patients with CRC significantly decreased pulmonary-related postoperative morbidity and mortality in this large cohort study. Laparoscopic surgery is a favorable method for elderly patients with CRC than open surgery in terms of less hospital stay and similar oncological outcomes.

Role of adjuvant chemotherapy in advanced stage upper urinary tract urothelial carcinoma after radical nephroureterectomy: A competing risk analysis.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 367-367
Author(s):  
Minyong Kang ◽  
Hyung Suk Kim ◽  
Jae Young Joung ◽  
Yong Ho Shin ◽  
Byong Chang Jeong ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Risk Analysis ◽  
Causes Of Death ◽  
Locally Advanced ◽  
Competing Risk ◽  
Radical Nephroureterectomy ◽  
Competing Risk Analysis ◽  
Cancer Specific Survival ◽  
Specific Mortality ◽  
Cancer Specific Mortality

367 Background: To determine whether adjuvant chemotherapy (ACH) influences cancer-specific mortality, bladder cancer-specific mortality, and other-cause mortality in patients with locally advanced upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU) through the use of competing risk analysis. Methods: Among 785 patients with UTUC who underwent RNU from 1994 through 2015, we analyzed 338 individuals with locally advanced UTUC (pathologic T3–T4 and/or positive lymph nodes) without distant metastases. Patients were classified into two groups according to receipt of ACH. The study endpoints were UTUC-, bladder cancer- and other cause-specific survivals. The association of potential risk factors with outcome was tested with the Fine and Gray regression model. Results: Overall, 42.6% (n = 144) received ACH following RNU. During a median follow-up duration of 31.5 months, rates of UTUC-, bladder cancer-, and other cause-mortalities were 32.5% (n = 110), 5.0% (n = 17), and 4.1% (n = 14), respectively. Of note, there were no significant differences in overall survival between the observation and ACH groups according to the competing risks of death (UTUC, bladder cancer, and other causes of death). Multivariate analysis showed that only older age at surgery (≥ 65 years; hazard ratio [HR] = 1.71) and positive resection margin (HR = 7.25) remained as poor predictors of UTUC-specific and bladder cancer-specific survival, respectively. Additionally, no factors were identified as independent predictors of other causes of death. Conclusions: In summary, through competing risk analysis, we demonstrated that postoperative chemotherapy did not improve UTUC-specific and bladder-cancer specific survival, nor other cause-specific survival, in patients with locally advanced UTUC who underwent RNU. These results can offer practical information for clinicians regarding treatment decision making in these patients, who are at high risk of death due to competing causes.

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