scholarly journals Effects of Wnt/β-Catenin Signal Pathway Regulated by miR-342-5p Targeting CBX2 on Proliferation, Metastasis and Invasion of Ovarian Cancer Cells

2020 ◽  
Vol Volume 12 ◽  
pp. 3783-3794 ◽  
Author(s):  
Yan Dou ◽  
Fengxia Chen ◽  
Yawan Lu ◽  
Huanhuan Qiu ◽  
Hongmei Zhang
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Signal Pathway ◽  
Ovarian Cancer Cells

scholarly journals NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1647
Author(s):  
Wen-Jing Liu ◽  
Ying-Xue Huang ◽  
Wei Wang ◽  
Ye Zhang ◽  
Bing-Jie Liu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Signal Pathway ◽  
Ovarian Cancer Cells ◽  
Therapeutic Resistance ◽  
Oxygen Species ◽  
Nadph Oxidase 4 ◽  
Development Of Resistance ◽  
Increased Sensitivity ◽  
Radiotherapy Resistance

Development of resistance to therapy in ovarian cancer is a major hinderance for therapeutic efficacy; however, new mechanisms of the resistance remain to be elucidated. NADPH oxidase 4 (NOX4) is responsible for higher NADPH activity to increase reactive oxygen species (ROS) production. In this study, we showed that higher levels of NOX4 were detected in a large portion of human ovarian cancer samples. To understand the molecular mechanism of the NOX4 upregulation, we showed that NOX4 expression was induced by HIF-1α and growth factor such as IGF-1. Furthermore, our results indicated that NOX4 played a pivotal role in chemotherapy and radiotherapy resistance in ovarian cancer cells. We also demonstrated that NOX4 knockdown increased sensitivity of targeted therapy and radiotherapy through decreased expression of HER3 (ERBB3) and NF-κB p65. Taken together, we identified a new HIF-1α/NOX4 signal pathway which induced drug and radiation resistance in ovarian cancer. The finding may provide a new option to overcome the therapeutic resistance of ovarian cancer in the future.

Cytotoxic effects of disulfiram and synergism with cisplatin on ovarian cancer cells in vitro

2018 ◽  
Author(s):  
F Guo ◽  
Z Yang ◽  
J Xu ◽  
J Sehouli ◽  
AE Albers ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Cytotoxic Effects
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